Process for making tablet using radiofrequency and lossy coated particles
In one aspect the present invention features a process for making a tablet comprising the step of applying radiofrequency energy to a powder blend comprising lossy coated particles and at least one pharmaceutically active agent to sinter said powder blend into a tablet, said lossy coated particles comprising a substrate having a Q value of greater than 100 that is at least partially coated with a lossy coating comprising Hydrogenated Starch Hydrolysate.
1. A process for making a tablet comprising the step of applying radiofrequency energy to a powder blend comprising lossy coated particles and at least one pharmaceutically active agent to sinter said powder blend into a tablet, said lossy coated particles comprising a substrate having a Q value of greater than 100 that is at least partially coated with a lossy coating; wherein said lossy coated particles comprise from about 1.5 to about 2.5%, by weight, of Hydrogenated Starch Hydrolysate and the hardness of the tablet is 1 kp or greater.
2. A process of claim 1 , wherein said substrate has a Q value of greater than 200.
3. A process of claim 1 , wherein said lossy coated particles have a Q value of greater than 100.
4. A process of claim 1 , wherein said powder blend has a Q value of greater than 100.
5. A process of claim 1 , wherein said powder blend comprises at least 20%, by weight, of said lossy coated particles.
6. A process of claim 1 , wherein said lossy coated particle comprises from about 0.1% A to about 3%, by weight, water.
7. A process of claim 1 , wherein said tablet disintegrates in the mouth when placed on the tongue in less than about 30 seconds.
8. A process of claim 1 , wherein said tablet disintegrates in the mouth when placed on the tongue in less than about 15 seconds.
9. The process of claim 1 , wherein said radiofrequency energy has a frequency of from about 13 MHz to about 40 MHz.
10. A process of claim 1 , wherein said tablets are formed within a tablet die.
11. A process of claim 1 , wherein said substrate comprises a starch, a sugar alcohol, or a sugar.
12. A process of claim 1 , wherein said substrate comprises maltitol or mannitol.
13. A process of claim 1 , wherein said substrate comprises said pharmaceutically active agent.
14. A process of claim 1 , wherein the friability of the tablet is less than about 5%.
15. The process of claim 1 wherein said tablet disintegrates in the mouth when placed on the tongue in less than about 15 seconds.
16. The process of claim 1 wherein said powder blend comprises lossy coated particles separate from said at least one pharmaceutically active agent.
17. A sintered tablet comprising sintered lossy coated particles and at least one pharmaceutically active agent, wherein said lossy coated particles comprise a substrate that is at least partially coated with a lossy coating,
wherein said lossy coated particles comprise from about 1.5 to about 2.5% by weight of Hydrogenated Starch Hydrolysate, said substrate has a Q value of greater than 100, said tablet having a hardness of 1 kp or greater and said tablet disintegrates in the mouth when placed on the tongue in less than about 15 seconds.