Methods and compositions for sleep disorders and other disorders
Use of particular substituted heterocycle fused gamma-carboline compounds as pharmaceuticals and pharmaceutical compositions comprising them for the treatment of one or more disorders involving the 5-HT2A, SERT and/or dopamine D2 pathways are disclosed. In addition, the compounds may be combined with other therapeutic agents for the treatment of one or more sleep disorders, depression, psychosis, dyskinesias, and/or Parkinson's disease or any combinations.
1. A method for the treatment of bipolar depression, comprising administering to a patient in need thereof a Compound of Formula I:
wherein X is O, —NH or —N(CH 3 ); and Y is —O— or —C(O)—, in free or pharmaceutically acceptable salt form.
2. The method of claim 1 , wherein the Compound of Formula I is
in free or pharmaceutically acceptable salt form.
3. The method according to claim 1 wherein said patient is unable to tolerate the side effects of conventional antipsychotic drugs.
4. The method according to claim 3 wherein said antipsychotic drugs are selected from the group consisting of haloperidol, aripiprazole, clozapine, olanzapine, quetiapine, risperidone and zipasidone.
5. The method according to claim 1 , wherein said patient is suffering from psychosis or Parkinson's disease.
6. The method according to claim 1 , wherein patient is suffering from depression.
7. The method according to claim 1 , wherein said patient is suffering from psychosis.
8. The method according to claim 1 , further comprising administration of one or more therapeutic agents selected from the group consisting of compounds that modulate GABA activity, a GABAB agonist, a 5-HT modulator, a melatonin agonist, an ion channel modulator, a serotonin-2 antagonist/reuptake inhibitor (SARIs), an orexin receptor antagonist, an H3 agonist, a noradrenergic antagonist, a galanin agonist, a CRH antagonist, human growth hormone, a growth hormone agonist, estrogen, an estrogen agonist, a neurokinin-1 drug, an anti-depressant, an antipsychotic agent, and an atypical antipsychotic agent, in free or pharmaceutically acceptable salt form.
9. The method according to claim 1 , further comprising administering one or more therapeutic agents selected from the group consisting of modafinil, armodafinil, doxepin, alprazolam, bromazepam, clobazam, clonazepam, clorazepate, diazepam, flunitrazepam, flurazepam, lorazepam, midazolam, nitrazepam, oxazepam, temazepam, triazolam, indiplon, zopiclone, eszopiclone, zaleplon, Zolpidem, gaboxadol, vigabatrin, tiagabine, EVT 201, estazolam, ketanserin, risperidone, eplivanserin, volinanserin, pruvanserin, MDL 100907, HY10275, APD125, AVE8488, repinotan, sarizotan, eptapirone, buspirone, MN-305, melatonin, ramelteon, VEC-162, PD-6735, agomelatine, lamotrigine, gabapentin, pregabalin, orexin, a 1,3-biarylurea, SB-334867-a, GW649868, a benzamide derivative, Org 50081, ritanserin, nefazodone, serzone, trazodone, Casopitant, amitriptyline, amoxapine, bupropion, citalopram, clomipramine, desipramine, doxepin, duloxetine, escitalopram, fluoxetine, fluvoxamine, imipramine, isocarboxazid, maprotiline, mirtazapine, nefazodone, nortriptyline, paroxetine, phenelzine sulfate, protriptyline, sertraline, tranylcypromine, trazodone, trimipramine, venlafaxine, chlorpromazine, haloperidol, droperidol, fluphenazine, loxapine, mesoridazine molindone, perphenazine, pimozide, prochlorperazine promazine, thioridazine, thiothixene, trifluoperazine, clozapine, aripiparazole, olanzapine, quetiapine, risperidone, ziprasidone and paliperidone, in free or pharmaceutically acceptable salt form.
10. The method according to claim 1 , wherein the amount of said Compound of Formula I administered is from 0.1 mg to 20 mg, in free or pharmaceutically acceptable salt form, provided that in the case of a salt, the weight is calculated as the free base.
11. The method according to claim 10 , wherein the amount of the Compound of Formula I administered is 0.5-10 mg.
12. The method according to claim 10 , wherein the amount of the Compound of Formula I administered is 2.5-5 mg.
13. The method according to claim 10 , wherein the amount of the Compound of Formula I administered is less than 5 mg.
14. The method according to claim 10 , wherein the amount of the Compound of Formula I administered is less than 2.5 mg.
15. The method of claim 2 wherein the Compound of Formula I is in the form of the tosylate salt.
16. The method according to claim 1 , further comprising administering one or more therapeutic agents selected from a group consisting of L-dopa, co-careldopa, duodopa, symmetrel, benzotropine, biperiden, bromocriptine, entacapone, pergolide, pramipexole, procyclidine, ropinirole, selegiline and tolcapone.
17. The method according to claim 10 , further comprising administering one or more therapeutic agents selected from a group consisting of L-dopa, co-careldopa, duodopa, stalova, symmetrel, benzotropine, biperiden, bromocriptine, entacapone, pergolide, pramipexole, procyclidine, ropinirole, selegiline and tolcapone.
18. A method for promoting regular sleep in the treatment:
of bipolar depression;
comprising administering to a patient in need thereof:
an atypical stimulant; and
a Compound of Formula I:
wherein X is O, —NH or —N(CH 3 ); and Y is —O— or —C(O)—, in free or pharmaceutically acceptable salt form.
19. The method according to claim 18 , wherein the compound of Formula I has the structure:
20. The method according to claim 19 wherein the Compound of Formula I is in the form of the tosylate salt.
21. The method according to claim 20 , wherein the amount of said Compound of Formula I administered is from 0.1 mg to 20 mg, in free or pharmaceutically acceptable salt form, provided that in the case of a salt, the weight is calculated as the free base.
22. The method according to claim 21 , wherein the amount of the Compound of Formula I administered is 0.5-10 mg.
23. The method according to claim 22 , wherein the amount of the Compound of Formula I administered is 2.5-5 mg.
24. The method according to claim 22 , wherein the amount of the Compound of Formula I administered is less than 5 mg.
25. The method according to claim 22 , wherein the amount of the Compound of Formula I administered is less than 2.5 mg.
26. The method according to claim 18 , wherein the atypical stimulant is selected from the group consisting of modafinil, adrafinil and armodafinil.
27. The method according to claim 18 , further comprising administration of one or more therapeutic agents selected from the group consisting of compounds that modulate GABA activity, a GABAB agonist, a 5-HT modulator, a melatonin agonist, an ion channel modulator, a serotonin-2 antagonist/reuptake inhibitor (SARIs), an orexin receptor antagonist, an H3 agonist, a noradrenergic antagonist, a galanin agonist, a CRH antagonist, human growth hormone, a growth hormone agonist, estrogen, an estrogen agonist, a neurokinin-I drug, an anti-depressant, and an antipsychotic agent, in free or pharmaceutically acceptable salt form.
28. The method according to claim 18 , further comprising administration of one or more therapeutic agents selected from the group consisting of modafinil, armodafinil, doxepin, alprazolam, bromazepam, clobazam, clonazepam, clorazepate, diazepam, flunitrazepam, flurazepam, lorazepam, midazolam, nitrazepam, oxazepam, temazepam, triazolam, indiplon, zopiclone, eszopiclone, zaleplon, Zolpidem, gaboxadol, vigabatrin, tiagabine, EVT 201, estazolam, ketanserin, risperidone, eplivanserin, volinanserin, pruvanserin, MDL 100907, HY10275, APD125, AVE8488, repinotan, sarizotan, eptapirone, buspirone, MN-305, melatonin, ramelteon, VEC-162, PD-6735, agomelatine, lamotrigine, gabapentin, pregabalin, orexin, a 1,3-biarylurea, SB-334867-a, GW649868, a benzamide derivative, Org 50081, ritanserin, nefazodone, serzone, trazodone, Casopitant, amitriptyline, amoxapine, bupropion, citalopram, clomipramine, desipramine, doxepin, duloxetine, escitalopram, fluoxetine, fluvoxamine, imipramine, isocarboxazid, maprotiline, mirtazapine, nefazodone, nortriptyline, paroxetine, phenelzine sulfate, protriptyline, sertraline, tranylcypromine, trazodone, trimipramine, venlafaxine, chlorpromazine, haloperidol, droperidol, fluphenazine, loxapine, mesoridazine molindone, perphenazine, pimozide, prochlorperazine promazine, thioridazine, thiothixene, trifluoperazine, clozapine, aripiparazole, olanzapine, quetiapine, risperidone, ziprasidone and paliperidone, in free or pharmaceutically acceptable salt form.