Cosmetic compositions and uses thereof
The present invention relates generally to methods and compositions comprising Hylocereus undatus fruit extract and Aloe barbadensis leaf extract, useful as antioxidants and/or inhibiting TNF-α expression.
1. A method of reducing oxidative damage and reducing TNF-α expression in skin, the method comprising topically applying to inflamed skin a composition comprising 0.01% w/w to 5% w/w of Hylocereus undatus fruit extract, 0.01% w/w to 1% of Aloe barbadensis leaf extract, and a skin conditioning agent selected from 0.001% w/w to 5% w/w of methyldihydrojasmonate and/or 0.0001% w/w to 1% w/w of panthenol, to reduce oxidative damage and TNF-α expression in the skin.
2. The method of claim 1 , wherein:
the Hylocereus undatus fruit extract is a water extract of Hylocereus undatus fruit, wherein the Hylocereus undatus fruit extract comprises water, glycerin, and preservatives; and
the Aloe barbadensis leaf extract is an aqueous extract of the leaves of Aloe barbadensis , wherein the Aloe barbadensis extract comprises water and butylene glycol.
3. The method of claim 1 , wherein the composition is formulated as a emulsion, solution, or gel.
4. The method of claim 3 , wherein the composition is an emulsion.
5. The method of claim 1 , wherein the composition comprises 30% w/w to 95% w/w of water.
6. The method of claim 1 , wherein the composition further comprises glycerin, disodium EDTA, at least one pH adjuster, and at least one preservative.
7. The method of claim 6 , wherein the composition is formulated as a gel.
8. The method of claim 1 , wherein the composition further comprises sodium methyl cocoyl taurate, acrylates copolymer, and cocamidopropyl hydroxysultaine.
9. The method of claim 8 , wherein the composition is formulated as a surfactant-based gel.
10. The method of claim 1 , wherein the composition further comprises ammonium acryloyldimethyltaurate/VP copolymer.
11. The method of claim 10 , wherein the composition is formulated as a gel.
12. The method of claim 1 , wherein the composition further comprises acrylates/C10-30 alkyl acrylate crosspolymer, carbomer, and triethanolamine.
13. The method of claim 12 , wherein the composition further comprises homosalate, benzophenone-3, ethylhexyl salicylate, avobenzone, and octocrylene.
14. The method of claim 13 , wherein the composition is formulated as a gel emulsion.
15. The method of claim 1 , wherein the composition further comprises denatured alcohol.
16. The method of claim 15 , wherein the composition is formulated as a cleansing toner.
17. The method of claim 1 , further comprising sodium C14-16 olefin sulfonate, cocamidopropyl betaine, cocoamphodiacetate, PEG-120 methyl glucose dioleate, and PEG-80 sorbitan laurate.
18. The method of claim 17 , wherein the composition is formulated as a facial cleansing gel.
19. The method of claim 1 , wherein the composition comprises 0.01% w/w to less than 1% w/w of Hylocereus undatus fruit extract and 0.01% w/w to less than 1% Aloe barbadensis leaf extract.
20. The method of claim 1 , wherein the composition further comprises 30% w/w to 95% w/w of water, 0.001 to 10% w/w of glycerin, and 0.01 to 1% w/w of disodium EDTA.
21. The method of claim 1 , wherein the composition further comprises 0.001% w/w to 2% w/w of ethyl linalool.