Antibacterial biomedical implants and associated materials, apparatus, and methods
Methods for improving the antibacterial characteristics of biomedical implants and related implants manufactured according to such methods. In some implementations, a biomedical implant comprising a silicon nitride ceramic material may be subjected to a surface roughening treatment so as to increase a surface roughness of at least a portion of the biomedical implant to a roughness profile having an arithmetic average of at least about 500 nm Ra. In some implementations, a coating may be applied to a biomedical implant. Such a coating may comprise a silicon nitride ceramic material, and may be applied instead of, or in addition to, the surface roughening treatment process.
1. A method for improving the antibacterial characteristics of a biomedical implant, the method comprising the steps of:
providing a biomedical implant comprising a polymeric or metallic substrate material; and
coating the biomedical implant with a powder comprising β-SiYAlON, wherein the coating has a thickness of 1 μm to 125 μm,
wherein the coated biomedical implant has increased bacterial resistance as compared to the substrate material alone.
2. The method of claim 1 , wherein the biomedical implant comprises an intervertebral spinal implant.
3. The method of claim 1 , wherein the biomedical implant comprises at least one of poly-ether-ether-ketone (PEEK) and titanium.
4. The method of claim 1 , wherein the biomedical implant comprises PEEK.
5. The method of claim 1 , wherein the biomedical implant comprises PEEK and β-SiYAlON powder.
6. The method of claim 3 , wherein the biomedical implant comprises titanium.
7. A biomedical implant with improved antibacterial characteristics comprising:
a polymeric or metallic substrate material; and
a coating on the substrate material comprising a powder comprising β-SiYAlON, wherein the coating has a thickness of 1 μm to 125 μm,
wherein the biomedical implant has increased bacterial resistance as compared to the substrate material alone.
8. The biomedical implant of claim 7 , wherein the substrate material comprises at least one of poly-ether-ether-ketone (PEEK) and titanium.
9. The biomedical implant of claim 7 , wherein the substrate material comprises PEEK and the coating comprises β-SiYAlON powder.
10. The biomedical implant of claim 7 , wherein the biomedical implant is selected from an intervertebral spinal implant, a hip implant, or a bone screw.
11. The biomedical implant of claim 7 , wherein the biomedical implant comprises a hip implant with a silicon nitride coating on a femoral stem of the hip implant.
12. The biomedical implant of claim 7 , wherein the biomedical implant comprises a titanium bone screw.
13. A biomedical implant with improved antibacterial characteristics comprising:
a polymeric or metallic substrate material; and
a coating on the substrate material consisting essentially of a powder comprising β-SiYAlON, wherein the coating has a thickness of 1 μm to 125 μm.
14. The biomedical implant of claim 13 , wherein the substrate material comprises at least one of poly-ether-ether-ketone (PEEK) and titanium.
15. The biomedical implant of claim 13 , wherein the substrate material comprises PEEK.
16. The biomedical implant of claim 13 , wherein the biomedical implant is selected from an intervertebral spinal implant, a hip implant, or a bone screw.
17. The biomedical implant of claim 13 , wherein the biomedical implant comprises a hip implant with a silicon nitride coating on a femoral stem of the hip implant.
18. The biomedical implant of claim 13 , wherein the biomedical implant comprises a titanium bone screw.
19. A biomedical implant with improved antibacterial characteristics comprising:
a polymeric substrate material filled with about 10 vol. % to about 20 vol. % of a powder comprising β-SiYAlON.
20. The biomedical implant of claim 19 , wherein the substrate material comprises poly-ether-ether-ketone (PEEK).
21. The biomedical implant of claim 19 , wherein the biomedical implant is selected from an intervertebral spinal implant, a hip implant, or a bone screw.