Granted Patent
B2
US 10,035,818 · App. 15/472,476 · Granted Jul 31, 2018
Polyethylene glycol based prodrug of adrenomedullin and use thereof
Inventors:
Ingo Flamme (Reichshof, DE); Johannes Köbberling (Neuss, DE); Hans-Georg Lerchen (Leverkusen, DE); Nils Griebenow (Dormagen, DE); Rudolf Schohe-Loop (Wuppertal, DE); Sven Wittrock (Wuppertal, DE); Maria Köllnberger (Velbert, DE); Frank Wunder (Wuppertal, DE); Gorden Redlich (Bochum, DE); Andreas Knorr (Erkrath, DE); Julie Marley (Merseyside, GB); Iain Pritchard (Merseyside, GB)
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Abstract
The invention relates to novel polyethylene glycol (PEG) based prodrug of Adrenomedullin, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for producing medicaments for treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders.
Claims (8)
1. A compound of the formula (IV)
wherein
n represents 0, 1, 2, or 3; and
R 1 represents hydrogen, methyl, ethyl, n-propyl or isopropyl.
2. The compound of claim 1 wherein
n represents 1 or 2; and
R 1 is hydrogen or methyl.
3. The compound of claim 1 wherein the is a compound of formula (III)
Assignments (2)
CHANGE OF ADDRESS
Recorded Jun 12, 2023
From: BAYER INTELLECTUAL PROPERTY GMBH
To: BAYER INTELLECTUAL PROPERTY GMBH
Reel/Frame 064021/0344 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Mar 29, 2017
From: FLAMME, INGO, DR.; KÖBBERLING, JOHANNES, DR.; LERCHEN, HANS-GEORG, DR.; GRIEBENOW, NILS, DR.; SCHOHE-LOOP, RUDOLF, DR.; WITTROCK, SVEN, DR.; KÖLLNBERGER, MARIA, DR.; WUNDER, FRANK, DR.; REDLICH, GORDEN, DR.; KNORR, ANDREAS, DR.; MARLEY, JULIE, DR.; PRITCHARD, IAIN, DR.
To: BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH
Reel/Frame 041782/0218 →
Priority Claims (1)
EP 11187735
· Nov 3, 2011
· regional
Continuity (3)
Continuation
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