Caspofungin Acetate Formulations
A caspofungin composition includes caspofungin acetate and at least one amino acid, where the composition is a solid. The solid composition may be made by forming a liquid mixture including a solvent, caspofungin acetate and the amino acid(s), and lyophilizing the liquid mixture.
1 . A composition, comprising:
caspofungin acetate, and
at least one an amino acid;
where the composition is a solid.
2 . The composition of claim 1 , where the at least one amino acid comprises an amino acid having at least two primary or secondary amine groups.
3 . The composition of claim 2 , where the at least one amino acid is an amino acid selected from the group consisting of arginine, asparagine, lysine, methyl lysine, and ornithine.
4 . The composition of claim 1 , where the at least one amino acid is selected from the group consisting of alanine, 4-aminobutanoic acid, 3-aminopentanoic acid, 5-aminopentanoic acid, 6-aminohexanoic acid, 8-aminooctanoic acid, arginine, aspartic acid, asparagine, cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, methyl lysine, ornithine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine and valine.
5 . The composition of claim 1 , where the at least one amino acid is selected from the group consisting of 6-aminohexanoic acid, arginine, asparagine, glycine, lysine, methyl lysine, and ornithine.
6 . The composition of claim 1 , where the at least one amino acid comprises at least two amino acids.
7 . The composition of claim 1 , comprising from 10 to 150 mg caspofungin acetate.
8 . The composition of claim 1 , comprising from 25 to 100 mg caspofungin acetate.
9 . The composition of claim 1 , comprising from 50 to 70 mg caspofungin acetate.
10 . The composition of claim 1 , where the mass ratio of the at least one amino acid to caspofungin acetate is at least 3:5.
11 . The composition of claim 1 , where the mass ratio of the at least one amino acid to caspofungin acetate is at least 1:1.
12 . The composition of claim 1 , where the mass ratio of the at least one amino acid to caspofungin acetate is at least 2:1.
13 . The composition of claim 1 , where the mass ratio of the at least one amino acid to caspofungin acetate is at most 3:1.
14 . The composition of claim 1 , where the mass ratio of the at least one amino acid to caspofungin acetate is at most 2:1.
15 . The composition of claim 1 , where the mass ratio of the at least one amino acid to caspofungin acetate is from 2:5 to 3:1.
16 . The composition of claim 1 , where the mass ratio of the at least one amino acid to caspofungin acetate is from 3:5 to 2:1.
17 . The composition of claim 1 , where the mass ratio of the at least one amino acid to caspofungin acetate is from 1:1 to 3:1.
18 . A composition, formed by a method comprising:
forming a liquid mixture comprising
a solvent,
caspofungin acetate, and
at least one an amino acid; and
lyophilizing the liquid mixture to form a solid composition.
19 . The composition of claim 18 , where the at least one amino acid is an amino acid having at least two primary or secondary amine groups.
20 . The composition of claim 19 , where the at least one amino acid is an amino acid selected from the group consisting of arginine, asparagine, lysine, methyl lysine, and ornithine.
21 . The composition of claim 18 , where the at least one amino acid is selected from the group consisting of alanine, 4-aminobutanoic acid, 3-aminopentanoic acid, 5-aminopentanoic acid, 6-aminohexanoic acid, 8-aminooctanoic acid, arginine, aspartic acid, asparagine, cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, methyl lysine, ornithine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine and valine.
22 . The composition of claim 18 , where the at least one amino acid is selected from the group consisting of 6-aminohexanoic acid, arginine, asparagine, glycine, lysine, methyl lysine, and ornithine.
23 . The composition of claim 18 , where the at least one amino acid comprises at least two amino acids.
24 . The composition of claim 18 , comprising from 10 to 150 mg caspofungin acetate.
25 . The composition of claim 18 , comprising from 25 to 100 mg caspofungin acetate.
26 . The composition of claim 18 , comprising from 50 to 70 mg caspofungin acetate.
27 . The composition of claim 18 , where the mass ratio of the at least one amino acid to caspofungin acetate is at least 3:5.
28 . The composition of claim 18 , where the mass ratio of the at least one amino acid to caspofungin acetate is at least 1:1.
29 . The composition of claim 18 , where the mass ratio of the at least one amino acid to caspofungin acetate is at least 2:1.
30 . The composition of claim 18 , where the mass ratio of the at least one amino acid to caspofungin acetate is at most 3:1.
31 . The composition of claim 18 , where the mass ratio of the at least one amino acid to caspofungin acetate is at most 2:1.
32 . The composition of claim 18 , where the mass ratio of the at least one amino acid to caspofungin acetate is from 2:5 to 3:1.
33 . The composition of claim 18 , where the mass ratio of the at least one amino acid to caspofungin acetate is from 3:5 to 2:1.
34 . The composition of claim 18 , where the mass ratio of the at least one amino acid to caspofungin acetate is from 1:1 to 3:1.
35 . The composition of claim 18 , where the mass ratio of the at least one amino acid to caspofungin acetate in the liquid mixture is at least 2:5.
36 . The composition of claim 18 , where the mass ratio of the at least one amino acid to caspofungin acetate in the liquid mixture is at least 3:5.
37 . The composition of claim 18 , where the mass ratio of the at least one amino acid to caspofungin acetate in the liquid mixture is at least 1:1.
38 . A composition, comprising:
from 50 to 70 mg caspofungin acetate, and arginine;
where the mass ratio of arginine to caspofungin acetate is from 2:5 to 3:1, and the composition is solid.
39 . The composition of claim 38 , where the mass ratio of arginine to caspofungin acetate is from 3:5 to 2:1.
40 . The composition of claim 38 , where the mass ratio of arginine to caspofungin acetate is from 1:1 to 3:1.