IP Library › Granted Patent US 10,155,004
Granted Patent B2
US 10,155,004 · App. 15/478,803 · Granted Dec 18, 2018

17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives, method of production thereof and use thereof for the treatment of diseases

Inventors: Wolfgang Schwede (Glienicke, DE); Ulrich Klar (Berlin, DE); Carsten Moller (Berlin, DE); Andrea Rotgeri (Berlin, DE); Wilhelm Bone (Berlin, DE)
Assignee: BAYER INTELLECTUAL PROPERTY GMBH
A61K31/567A61K31/573C07J31/006C07J41/0083
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Quick Facts
Patent No.
US 10,155,004
App. No.
15/478,803
Granted
Dec 18, 2018
Kind
B2
Abstract

The invention relates to 17-hydroxy-17-pentafluoroethyl-estra-4,9(10)-dien-11-aryl derivatives of Formula I with progesterone antagonizing action and method of production thereof, use thereof for the treatment and/or prophylaxis of diseases and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular of fibroids of the uterus (myomas, uterine leiomyoma), endometriosis, heavy menstrual bleeds, meningiomas, hormone-dependent breast cancers and complaints associated with the menopause or for fertility control and emergency contraception.

Claims (4)

1. Method for the treatment of fibroid of the uterus, endometriosis, heavy menstrual bleed, meningioma, hormone-dependent breast cancer, fertility control, or emergency contraception comprising the step of administering (11β,17β)-17-Hydroxy-11-[4-(methylsulphonyl)phenyl]-17-(pentafluoroethyl)estra-4,9-dien-3-one of the formula

or pharmaceutical acceptable salts thereof.

2. Method according to claim 1 for the treatment of endometriosis.

3. Method according to claim 1 for the treatment of fibroids of the uterus.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 11, 2018
From: SCHWEDE, WOLFGANG; KLAR, ULRICH; MOLLER, CARSTEN; ROTGERI, ANDREA; BONE, WILHELM
To: BAYER PHARMA AKTIENGESELLSCHAFT
Reel/Frame 046842/0646 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 11, 2018
From: BAYER PHARMA AKTIENGESELLSCHAFT
To: BAYER INTELLECTUAL PROPERTY GMBH
Reel/Frame 046842/0752 →
Priority Claims (1)
DE 10 2009 034 362 · Jul 20, 2009 · national
Continuity (3)
Continuation 14731232 · Jun 4, 2015
Continuation 13376512
Related Publication 20170202857A1 · Jul 20, 2017