GPR119 agonist compounds

1. A compound of the formula (I):

wherein,

X 1 , X 2 , X 3 , X 4 and X 5 are each independently N, O, S or CH; and

X 4 and X 5 combine to form a five membered ring comprising one or more of heteroatoms each independently selected from N, O and S and the additional five membered ring may be further optionally substituted with one or more of the group selected from F, Cl, Br, I, CF 3 and C 1-6 alkyl;

wherein “ ” is a single or a double bond

R 1 and R 2 is independently selected from the group comprising —H, —O, C 1-6 alkyl, C 1-6 alkoxy, —(CH 2 )n, amino, —CO, —CONH, —NH(Alkyl), —N(Alkyl) 2 , —NH-aralkyl, —CH 2 O, —OCH(CH 3 ), halogen, COOR 3 , —CONR 3 R 4 , and NR 3 COR 4 ;

R 3 and R 4 is independently selected from the group comprising hydrogen and C 1-6 straight chain or branched chain alkyl which may be further substituted with halogen or C 1-6 alkyl;

n is 0, 1, 2 or 3;

A is selected from

B is selected from

and pharmaceutically acceptable salts, hydrates and stereoisomers thereof.

2. The compound of claim 1 having the formula (II):

3. The compound of claim 2 , wherein A is

4. The compound of claim 2 , wherein A is

5. The compound of claim 2 , wherein A is

6. The compound of claim 2 , wherein A is

7. The compound of claim 2 having significant dose dependent glucose reduction at both 3mpk and 10mpk in oral glucose tolerance test in rat model.

8. The compound of claim 2 showing significant dose dependent glucose reduction at both 3mpk and 10mpk in oral glucose tolerance test in mice.

9. The compound of claim 2 showing active GLP-1 secretion greater than ˜1 fold with respect to the vehicle.

10. The compound of claim 1 having the structure:

1016

3-isopropyl-5-(1-(6-(4- (methylsulfonyl)phenyl) imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)piperidin-4-yl)- 1,2,4-oxadiazole

1017

3-isopropyl-5-(4-(((6-(4- (methylsulfonyl)phenyl) imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)oxy)methyl) piperidin-1-yl)-1,2,4- oxadiazole

1018

3-isopropyl-5-(4-((6-(4- (methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)oxy)piperidin-1- yl)-1,2,4-oxadiazole

1019

2-(1-benzylpiperidin-4- yl)-6-(4-(methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazole

1020

isopropyl 4-(6-(4- (methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)piperazine-1- carboxylate

1021

isopropyl 4-((6-(4- (methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)amino)piperidine- 1-carboxylate

1022

isopropyl 4-(methyl(6-(4- (methylsulfonyl)phenyl) imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)amino)piperidine- 1-carboxylate

1023

N-(1-(5-ethylpyrimidin- 2-yl)piperidin-4-yl)- 6-(4-(methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazol-2- amine

1024

isopropyl 4-(6-(4- (methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)piperidine-1- carboxylate

1025

4-(methyl(6-(4- (methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)amino)piperidine- 1-carboxamide

1026

4-(6-(4- (methylsulfonyl)phenyl) imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)piperidine-1- carboxamide

1027

3-isopropyl-5-(4-(6-(4- (methylsulfonyl)phenyl) imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)piperidin-1-yl)- 1,2,4-oxadiazole

1028

1-(4-(2-(4- (methylsulfonyl)phenyl) imidazo[2,1-b] [1,3,4]thiadiazol-6- yl)piperidin-1- yl)ethanone

1029

N-(1-(3-isopropyl-1,2,4- oxadiazol-5-yl) piperidin-4-yl)-N- methyl-6-(4- (methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazol-2- amine

11. The compound of claim 1 having the structure:

1030

isopropyl 4-(2-(4- (methylsulfonyl)phenyl) imidazo[2,1-b] [1,3,4]thiadiazol-6- yl)piperidine-1- carboxylate

1031

6-(4-(methylsulfonyl) phenyl)-2-(1- (methylsulfonyl) piperidin-4- yl)imidazo[2,1-b] [1,3,4]thiadiazole

1032

3-isopropyl-5-(4-(2-(4- (methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazol-6- yl)piperidin-1-yl)- 1,2,4-oxadiazole

1033

N,N-dimethyl-4-(6-(4- (methylsulfonyl)phenyl) imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)piperidine-1- carboxamide

1034

isopropyl 4-(2-(4- (dimethylcarbamoyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazol-6- yl)piperidine-1- carboxylate

1035

isopropyl 4-(2-(4-((2- methoxyethyl)carbamoyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazol-6- yl)piperidine-1- carboxylate

1036

4-(2-(4-(3-isopropyl- 1,2,4-oxadiazol-5- yl)piperidin-1- yl)imidazo[2,1-b] [1,3,4]thiadiazol-6-yl)- N,N-dimethylbenzamide

1037

(4-(2-(4-(3-isopropyl- 1,2,4-oxadiazol-5- yl)piperidin-1- yl)imidazo[2,1-b] [1,3,4]thiadiazol-6- yl)phenyl)(morpholino) methanone

1038

2-(1-benzylpiperidin-4- yl)-6-((4-(methylsulfonyl) phenoxy)methyl)imidazo [2,1-b][1,3,4]thiadiazole

1039

4-(2-(4-(3-isopropyl- 1,2,4-oxadiazol-5- yl)piperidin-1-yl)iidazo [2,1-b][1,3,4]thiadiazol- 6-yl)-N-(2- methoxyethyl)benzamide

1040

3-isopropyl-5-(1-(6- ((4-(methylsulfonyl) phenoxy)methyl) imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)piperidin-4-yl)- 1,2,4-oxadiazole

1041

isopropyl 4-(6-((4- (methylsulfonyl)phenoxy) methyl)imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)piperidine-1- carboxylate

1042

3-isopropyl-5-(4-((6-((4- (methylsulfonyl)phenoxy) methyl)imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)oxy)piperidin-1- yl)-1,2,4-oxadiazole

1043

4-((2-(4-(3-isopropyl- 1,2,4-oxadiazol-5- yl)piperidin-1- yl)imidazo[2,1- b][1,3,4]thiadiazol-6- yl)methoxy)-N,N- dimethylbenzamide

1044

5-(1-(5-chloro-6-(4- (methylsulfonyl)phenyl) imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)piperidin-4-yl)-3- isopropyl-1,2,4- oxadiazole

1045

3-cyclopropyl-5-(1-(6-(4- (methylsulfonyl)phenyl) imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)piperidin-4-yl)- 1,2,4-oxadiazole

1046

4-(2-(4-(3-isopropyl- 1,2,4-oxadiazol-5- yl)piperidin-1- yl)imidazo[2,1-b] [1,3,4]thiadiazol-6- yl)benzonitrile

1047

4-(2-(1-(1-(3-isopropyl- 1,2,4-oxadiazol-5- yl)piperidin-4- yl)ethoxy)imidazo[2,1-b] [1,3,4]thiadiazol- 6-yl)benzonitrile

1048

4-(2-(1-(1-(3-isopropyl- 1,2,4-oxadiazol-5- yl)piperidin-4- yl)ethoxy)imidazo[2,1-b] [1,3,4]thiadiazol- 6-yl)-N,N- dimethylbenzamide

1049

N,N-dimethyl-4-(2-(1-(1- (5-propylpyrimidin- 2-yl)piperidin-4- yl)ethoxy)imidazo[2,1-b] [1,3,4]thiadiazol- 6-yl)benzamide

12. The compound of claim 1 having the structure:

1050

3-isopropyl-5-(4-(1-((6- (pyridin-4- yl)imidazo[2,1- b][1,3,4]thiadiazol-2- yl)oxy)ethyl)piperidin- 1-yl)-1,2,4-oxadiazole

1051

3-isopropyl-5-(1-(6- (pyridin-4- yl)imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)piperidin-4-yl)- 1,2,4-oxadiazole

1052

5-(1-(5-chloro-6- (pyridin-4- yl)imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)piperidin-4-yl)-3- isopropyl-1,2,4- oxadiazole

1053

4-(2-((1-(3-isopropyl- 1,2,4-oxadiazol-5- yl)piperidin-4- yl)methoxy)imidazo [2,1-b][1,3,4]thiadiazol- 6-yl)benzonitrile

1054

3-isopropyl-5-(4-(((6- (pyridin-4- yl)imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)oxy)methyl) piperidin-1-yl)-1,2,4- oxadiazole

1055

3-isopropyl-5-(4-(1-((6- (6-(methylsulfonyl) pyridin-3-yl)imidazo [2,1-b][1,3,4]thiadiazol- 2-yl)oxy)ethyl) piperidin-1-yl)-1,2,4- oxadiazole

1056

2-(1-(1-(5- ethylpyrimidin-2- yl)piperidin-4- yl)ethoxy)-6- (pyridin-4- yl)imidazo[2,1-b] [1,3,4]thiadiazole

1057

3-isopropyl-5-(4-(1-((6- (4-(methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)oxy)ethyl)piperidin- 1-yl)-1,2,4-oxadiazole

1058

(R)-3-isopropyl-5-(4-(1- ((6-(6-(methylsulfonyl) pyridin-3-yl)imidazo [2,1-b][1,3,4]thiadiazol- 2-yl)oxy)ethyl)piperidin- 1-yl)-1,2,4-oxadiazole

1059

(R)-3-isopropyl-5-(4-(1- ((6-(pyridin-4- yl)imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)oxy)ethyl)piperidin- 1-yl)-1,2,4-oxadiazole

1060

(R)-3-isopropyl-5-(4-(1- ((6-(4-(methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)oxy)ethyl)piperidin- 1-yl)-1,2,4-oxadiazole

1061

5-(4-(1-((5-fluoro-6-(4- (methylsulfonyl)phenyl) imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)oxy)ethyl)piperidin- 1-yl)-3-isopropyl- 1,2,4-oxadiazole

1062

(R)-2-(1-(1-(5- ethylpyrimidin-2- yl)piperidin-4- yl)ethoxy)-6-(4- (methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazole

1063

5-(4-(1-((5-chloro-6-(4- (methylsulfonyl)phenyl) imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)oxy)ethyl)piperidin- 1-yl)-3-isopropyl- 1,2,4-oxadiazole

1064

(S)-5-(4-(1-((6-(3- fluoropyridin-4- yl)imidazo[2,1- b][1,3,4]thiadiazol-2- yl)oxy)ethyl)piperidin- 1-yl)-3-isopropyl- 1,2,4-oxadiazole

1065

(R)-5-(4-(1-((6-(2- fluoropyridin-4- yl)imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)oxy)ethyl)piperidin- 1-yl)-3-isopropyl- 1,2,4-oxadiazole

1066

(R)-5-(4-(1-((5-fluoro-6- (4-(methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)oxy)ethyl)piperidin- 1-yl)-3-isopropyl- 1,2,4-oxadiazole

1067

(S)-6-(4- (methylsulfonyl) phenyl)-2-(1-(1-(5- propylpyrimidin-2- yl)piperidin-4-yl) ethoxy)imidazo[2,1-b] [1,3,4]thiadiazole

1068

(S)-4-(2-(1-(1-(3- isopropyl-1,2,4- oxadiazol-5- yl)piperidin-4- yl)ethoxy)imidazo[2,1-b] [1,3,4]thiadiazol- 6-yl)pyridine 1-oxide

1069

2-(1-(1-(5- chloropyrimidin-2- yl)piperidin-4- yl)ethoxy)-6-(4- (methylsulfonyl) phenyl)imidazo[2,1- b][1,3,4]thiadiazole

13. The compound of claim 1 having the structure:

1070

2-(1-(1-(5- isopropylpyrimidin- 2-yl)piperidin-4- yl)ethoxy)-6-(4- (methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazole

1071

(S)-5-(4-(1-((6-(2- chloropyrimidin-5- yl)imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)oxy)ethyl)piperidin- 1-yl)-3-isopropyl- 1,2,4-oxadiazole

1072

(S)-3-isopropyl-5- (4-(1-((6-(2- (methylsulfonyl) pyrimidin-5- yl)imidazo[2,1-b] [1,3,4]thiadiazol-2- yl)oxy)ethyl)piperidin- 1-yl)-1,2,4-oxadiazole

1073

2-(1-(1-(3- (trifluoromethyl)- 1,2,4-oxadiazol-5- yl)piperidin-4- yl)ethoxy)-6-(4- (methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazole

1074

2-(1-(1-(3-isopropyl- 1,2,4-oxadiazol-5- yl)piperidin-4- yl)ethoxy)-6-(2- (methylsulfonyl) pyrimidin-5- yl)imidazo[2,1-b] [1,3,4]thiadiazole

1075

2-(1-(1-(3-isopropyl- 1,2,4-oxadiazol-5- yl)piperidin-4- yl)ethoxy)-6-(6- chloropyridin-3- yl)imidazo[2,1-b] [1,3,4]thiadiazole

1076

2-((R)-1-(1-(3- (trifluoromethyl)- 1,2,4-oxadiazol-5- yl)piperidin-4- yl)ethoxy)-6-(4- (methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazole

1077

2-((S)-1-(1-(3- (trifluoromethyl)- 1,2,4-oxadiazol-5- yl)piperidin-4- yl)ethoxy)-6-(4- (methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazole

1078

2-((S)-1-(1-(3-isopropyl- 1,2,4-oxadiazol-5-yl) piperidin-4-yl) ethoxy)-6-(3-fluoro- 4-(methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazole

1079

2-(1-(1-(3-isopropyl- 1,2,4-oxadiazol-5- yl)piperidin-4- yl)ethoxy)-6-(5- chloropyrazin-2- yl)imidazo[2,1-b] [1,3,4]thiadiazole

1080

2-((R)-1-(1-(5- ethylpyrimidin-2- yl)piperidin-4- yl)ethoxy)-6- (pyridin-4- yl)imidazo[2,1-b] [1,3,4]thiadiazole

1081

2-((R)-1-(1-(5- propylpyrimidin-2- yl)piperidin-4- yl)ethoxy)-6-(6- (methylsulfonyl) pyridin-3-yl) imidazo[2,1-b] [1,3,4]thiadiazole

1082

2-((S)-1-(1-(5- propylpyrimidin-2- yl)piperidin-4- yl)ethoxy)-6-(3- fluoropyridin-4- yl)imidazo[2,1-b] [1,3,4]thiadiazole

1083

2-((S)-1-(1-(5- chloropyrimidin-2- yl)piperidin-4- yl)ethoxy)-6-(4- (methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazole

1084

2-((R)-1-(1-(3-isopropyl- 1,2,4-oxadiazol-5-yl) piperidin-4-yl) ethoxy)-6-(6- (trifluoromethyl) pyridin-3-yl) imidazo[2,1-b] [1,3,4]thiadiazole

1085

2-((S)-1-(1-(5- propylpyrimidin-2- yl)piperidin-4- yl)ethoxy)-6-(2- fluoro-4- (methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazole

1086

2-((S)-1-(1-(5- ethylpyrimidin-2- yl)piperidin-4- yl)ethoxy)-6-(2- fluoro-4- (methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazole

1087

2-((R)-1-(1-(3- isopropyl- 1,2,4-oxadiazol-5- yl)piperidin-4- yl)ethoxy)-6-(5- chloropyrazin-2- yl)imidazo[2,1-b] [1,3,4]thiadiazole

1088

2-((R)-1-(1-(3-isopropyl- 1,2,4-oxadiazol-5- yl)piperidin-4- yl)ethoxy)-6-(2- fluoro-4- (methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazole

1089

2-((S)-1-(1-(3-isopropyl- 1,2,4-oxadiazol-5- yl)piperidin-4- yl)ethoxy)-6-(2- methoxypyridin-4- yl)imidazo[2,1-b] [1,3,4]thiadiazole

1090

2-((R)-1-(1-(5- chloropyrimidin-2- yl)piperidin-4- yl)ethoxy)-6-(2- fluoro-4- (methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazole

1091

2-(1-(1-(3-isopropyl- 1,2,4-oxadiazol-5- yl)piperidin-4- yl)ethoxy)-6-(2- (trifluoromethyl)-4- (methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazole

1092

2-(1-(1-(3-isopropyl- 1,2,4-oxadiazol-5- yl)piperidin-4- yl)ethoxy)-6-(3- (trifluoromethyl) pyridin-4-yl) imidazo[2,1-b] [1,3,4]thiadiazole

1093

2-((S)-1-(1-(5- ethylpyrimidin-2- yl)piperidin-4- yl)ethoxy)-6-(2- methoxypyridin-4- yl)imidazo[2,1-b] [1,3,4]thiadiazole

1094

2-((S)-1-(1-(5- propylpyrimidin-2- yl)piperidin-4- yl)ethoxy)-6-(2- methoxypyridin-4- yl)imidazo[2,1-b] [1,3,4]thiadiazole

1095

2-(1-(1-(3-isopropyl- 1,2,4-oxadiazol-5- yl)piperidin-4- yl)ethoxy)-6-(3- methoxypyridin-4- yl)imidazo[2,1-b] [1,3,4]thiadiazole

1096

4-(2-((S)-1-(1-(3- isopropyl-1,2,4- oxadiazol-5-yl) piperidin-4-yl) ethoxy)imidazo[2,1-b] [1,3,4]thiadiazol- 6-yl)-1-methylpyridin- 2(1H)-one

1097

2-((S)-1-(1-(3- isopropyl-1,2,4- oxadiazol-5-yl) piperidin-4-yl) ethoxy)-6-(3- fluoropyridin-4- yl)imidazo[2,1-b] [1,3,4]thiadiazole hydrochloride

1098

2-((S)-1-(1-(5- (trifluoromethyl) pyrimidin-2-yl) piperidin-4-yl) ethoxy)-6-(2-fluoro-4- (methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazole

1099

4-(2-((R)-1-(1-(3- isopropyl-1,2,4- oxadiazol-5- yl)piperidin-4- yl)ethoxy)imidazo [2,1-b][1,3,4] thiadiazol-6-yl)-3- fluorobenzonitrile

14. The compound of claim 1 having the structure:

1100

2-((R)-1-(1-(3-isopropyl- 1,2,4-oxadiazol-5- yl)piperidin-4- yl)ethoxy)-6-(2- fluoro-6- (methylsulfonyl)pyridin- 3-yl)imidazo[2,1-b] [1,3,4]thiadiazole

1101

isopropyl 4-(1-(6-(2- fluoro-4- (methylsulfonyl) phenyl)imidazo[2,1- b][1,3,4]thiadiazol-2- yloxy)ethyl)piperidine- 1-carboxylate

1102

2-((R)-1-(1-(5- ethylpyrimidin-2- yl)piperidin-4- yl)ethoxy)-6-(2- fluoro-6- (methylsulfonyl) pyridin-3-yl)imidazo [2,1-b][1,3,4]thiadiazole

1103

2-((S)-1-(1-(3-isopropyl- 1,2,4-oxadiazol-5- yl)piperidin-4- yl)ethoxy)-6-(2- methoxy-4- (methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazole

1104

2-((S)-1-(1-(3-isopropyl- 1,2,4-oxadiazol-5- yl)piperidin-4- yl)ethoxy)-6-(2- methyl-6- (methylsulfonyl) pyridin-3-yl)imidazo [2,1-b][1,3,4]thiadiazole

1105

2-((R)-1-(1-(3-isopropyl- 1,2,4-oxadiazol-5- yl)piperidin-4- yl)ethoxy)-6-(2- fluoro-4-(1H-tetrazol- 5-yl)phenyl)imidazo [2,1-b][1,3,4]thiadiazole hydrochloride

1106

tert-butyl 4-(1-(6-(6- fluoro-4- (methylsulfonyl) cyclohexa-1,5- dienyl)imidazo[2,1-b] [1,3,4]thiadiazol-2- yloxy)ethyl)piperidine- 1-carboxylate

1107

ethyl 4-(1-(6-(2-fluoro- 4-(methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazol-2- yloxy)ethyl)piperidine- 1-carboxylate

1108

isopropyl 4-((S)-1- (6-(2-fluoro-4- (methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazol-2- yloxy)ethyl)piperidine- 1-carboxylate

1109

3-fluoro-4-(2-(1-(1- (3-isopropyl-1,2,4- oxadiazol-5- yl)piperidin-4- yl)ethoxy)imidazo [2,1-b][1,3,4]thiadiazol- 6-yl)-N-methyl- benzenesulfonamide

1110

1-methylcyclopropyl 4- (1-(6-(2-fluoro-4- (methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazol-2- yloxy)ethyl)piperidine- 1-carboxylate

1111

2-(1-(1-(3-isopropyl- 1,2,4-oxadiazol-5- yl)piperidin-4- yl)ethoxy)-6-(thiazol- 5-yl)imidazo[2,1-b] [1,3,4]thiadiazole

1112

2-((S)-1-(1-(3-isopropyl- 1,2,4-oxadiazol-5- yl)piperidin-4- yl)ethoxy)-6-(2- methyl-4- (methylsulfonyl) phenyl)imidazo[2,1-b] [1,3,4]thiadiazole

1113

ethyl 4-((S)-1-(6-(2- fluoro-4- (methylsulfonyl) phenyl)imidazo[2,1- b][1,3,4]thiadiazol-2- yloxy)ethyl)piperidine- 1-carboxylate

15. The compound of claim 1 , which is

3-isopropyl-5-(1-(6-((4(methylsulfonyl)phenoxy)methyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl)piperidin-4-yl)-1,2,4-oxadiazole;

isopropyl-4-(6-((4-(methylsulfonyl)phenoxy)methyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl)piperidine-1-carboxylate;

3-isopropyl-5-(4-((6-((4-(methylsulfonyl)phenoxy)methyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl)oxy)piperidin-1-yl)-1,2,4-oxadiazole;

4-((2-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)methoxy)-N,N-dimethylbenzamide;

5-(1-(5-chloro-6-(4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole;

3-cyclopropyl-5-(1-(6-(4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl)piperidin-4-yl)-1,2,4-oxadiazole;

4-(2-(4-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzonitrile;

4-(2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzonitrile;

4-(2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)-N,N-dimethylbenzamide;

N,N-dimethyl-4-(2-(1-(1-(5-propylpyrimidin-2-yl)piperidin-4-yl)ethoxy)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzamide;

3-isopropyl-5-(4-(1-((6-(pyridin-4-yl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

3-isopropyl-5-(1-(6-(pyridin-4-yl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl)piperidin-4-yl)-1,2,4-oxadiazole;

5-(1-(5-chloro-6-(pyridin-4-yl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl)piperidin-4-yl)-3-isopropyl-1,2,4-oxadiazole;

4-(2-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzonitrile;

3-isopropyl-5-(4-(((6-(pyridin-4-yl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl)oxy)methyl)piperidin-1-yl)-1,2,4-oxadiazole;

3-isopropyl-5-(4-(1-((6-(6-(methylsulfonyl)pyridin-3-yl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

2-(1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)ethoxy)-6-(pyridin-4-yl)imidazo[2,1-b][1,3,4]thiadiazole;

3-isopropyl-5-(4-(1-((6-(4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

(R)-3-isopropyl-5-(4-(1-((6-(6-(methylsulfonyl)pyridin-3-yl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

(R)-3-isopropyl-5-(4-(1-((6-(pyridin-4-yl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole.

16. The compound of claim 1 , which is

(R)-3-isopropyl-5-(4-(1-((6-(4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole;

5-(4-(1-((5-fluoro-6-(4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl)oxy)ethyl)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole;

(R)-2-(1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)ethoxy)-6-(4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazole;

5-(4-(1-(5-chloro-6-(4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl)oxy)ethyl)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole;

(S)-5-(4-(1-((6-(3-fluoropyridin-4-yl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl)oxy)ethyl)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole;

(R)-5-(4-(1-((6-(2-fluoropyridin-4-yl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl)oxy)ethyl)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole;

(R)-5-(4-(1-((5-fluoro-6-(4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl)oxy)ethyl)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole;

(S)-6-(4-(methylsulfonyl)phenyl)-2-(1-(1-(5-propylpyrimidin-2-yl)piperidin-4-yl)ethoxy)imidazo[2,1-b][1,3,4]thiadiazole;

(S)-4-(2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)pyridine 1-oxide;

2-(1-(1-(5-chloropyrimidin-2-yl)piperidin-4-yl)ethoxy)-6-(4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazole;

2-(1-(1-(5-isopropylpyrimidin-2-yl)piperidin-4-yl)ethoxy)-6-(4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazole;

(S)-5-(4-(1-((6-(2-chloropyrimidin-5-yl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl)oxy)ethyl)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole; or

(S)-3-isopropyl-5-(4-(1-((6-(2-(methylsulfonyl)pyrimidin-5-yl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl)oxy)ethyl)piperidin-1-yl)-1,2,4-oxadiazole.

17. The compound of claim 1 , which is

2-((R)-1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-6-(pyridin-4-yl)imidazo[2,1-b][1,3,4]thiadiazole;

2-(1-(1-(3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-6-(4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazole;

2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-6-(2-(methylsulfonyl)pyrimidin-5-yl)imidazo[2,1-b][1,3,4]thiadiazole;

2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-6-(6-chloropyridin-3-yl)imidazo[2,1-b][1,3,4]thiadiazole;

2-((R)-1-(1-(3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-6-(4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazole;

2-((S)-1-(1-(3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-6-(4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazole;

2-((S)-1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-6-(3-fluoro-4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazole;

2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-6-(5-chloropyrazin-2-yl)imidazo[2,1-b][1,3,4]thiadiazole;

2-((R)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)ethoxy)-6-(pyridin-4-yl)imidazo[2,1-b][1,3,4]thiadiazole;

2-((R)-1-(1-(5-propylpyrimidin-2-yl)piperidin-4-yl)ethoxy)-6-(6-(methylsulfonyl)pyridin-3-yl)imidazo[2,1-b][1,3,4]thiadiazole;

2-((S)-1-(1-(5-propylpyrimidin-2-yl)piperidin-4-yl)ethoxy)-6-(3-fluoropyridin-4-yl)imidazo[2,1-b][1,3,4]thiadiazole;

2-((S)-1-(1-(5-chloropyrimidin-2-yl)piperidin-4-yl)ethoxy)-6-(4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazole;

2-((R)-1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-6-(6-(trifluoromethyl)pyridin-3-yl)imidazo[2,1-b][1,3,4]thiadiazole;

2-((S)-1-(1-(5-propylpyrimidin-2-yl)piperidin-4-yl)ethoxy)-6-(2-fluoro-4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazole;

2-((S)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)ethoxy)-6-(2-fluoro-4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazole;

2-((R)-1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-6-(5-chloropyrazin-2-yl)imidazo[2,1-b][1,3,4]thiadiazole;

2-((R)-1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-6-(2-fluoro-4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazole;

2-((S)-1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-6-(2-methoxypyridin-4-yl)imidazo[2,1-b][1,3,4]thiadiazole;

2-((R)-1-(1-(5-chloropyrimidin-2-yl)piperidin-4-yl)ethoxy)-6-(2-fluoro-4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazole;

2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-6-(2-(trifluoromethyl)-4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazole;

2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-6-(3-(trifluoromethyl)pyridin-4-yl)imidazo[2,1-b][1,3,4]thiadiazole;

2-((S)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)ethoxy)-6-(2-methoxypyridin-4-yl)imidazo[2,1-b][1,3,4]thiadiazole;

2-((S)-1-(1-(5-propylpyrimidin-2-yl)piperidin-4-yl)ethoxy)-6-(2-methoxypyridin-4-yl)imidazo[2,1-b][1,3,4]thiadiazole;

2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-6-(3-methoxypyridin-4-yl)imidazo[2,1-b][1,3,4]thiadiazole;

4-(2-((S)-1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)-1-methylpyridin-2(1H)-one;

2-((S)-1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-6-(3-fluoropyridin-4-yl)imidazo[2,1-b][1,3,4]thiadiazole hydrochloride;

2-((S)-1-(1-(5-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-yl)ethoxy)-6-(2-fluoro-4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazole;

4-(2-((R)-1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)imidazo[2,1-b][1,3,4]thiadiazol-6-yl)-3-fluorobenzonitrile;

2-((R)-1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-6-(2-fluoro-6-(methylsulfonyl)pyridin-3-yl)imidazo[2,1-b][1,3,4]thiadiazole;

isopropyl 4-(1-(6-(2-fluoro-4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yloxy)ethyl)piperidine-1-carboxylate;

2-((R)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)ethoxy)-6-(2-fluoro-6-(methylsulfonyl)pyridin-3-yl)imidazo[2,1-b][1,3,4]thiadiazole;

2-((S)-1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-6-(2-methoxy-4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazole;

2-((S)-1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-6-(2-methyl-6-(methylsulfonyl)pyridin-3-yl)imidazo[2,1-b][1,3,4]thiadiazole;

2-((R)-1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-6-(2-fluoro-4-(1H-tetrazol-5-yl)phenyl)imidazo[2,1-b][1,3,4]thiadiazole hydrochloride;

tert-butyl 4-(1-(6-(6-fluoro-4-(methylsulfonyl)cyclohexa-1,5-dienyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yloxy)ethyl)piperidine-1-carboxylate;

ethyl 4-(1-(6-(2-fluoro-4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yloxy)ethyl)piperidine-1-carboxylate;

isopropyl 4-((S)-1-(6-(2-fluoro-4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yloxy)ethyl)piperidine-1-carboxylate; or

1-methylcyclopropyl 4-(1-(6-(2-fluoro-4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yloxy)ethyl)piperidine-1-carboxylate.

18. The compound of claim 1 , which is

2-(1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-6-(thiazol-5-yl)imidazo[2,1-b][1,3,4]thiadiazole;

2-((S)-1-(1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)ethoxy)-6-(2-methyl-4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazole; or

ethyl 4-((S)-1-(6-(2-fluoro-4-(methylsulfonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yloxy)ethyl)piperidine-1-carboxylate.

19. A method of treating diseases and conditions mediated through GPR119 comprising administering the compound of claim 1 to a patient in need thereof.

20. A method of treatment diseases and conditions mediated through GPR119 comprising administering the compound of claim 2 to a patient in need thereof.

21. The method of claim 19 , wherein said disease is metabolic disorder.

22. The method of claim 20 , wherein said disease is metabolic disorder.

23. The method of claim 21 , wherein said disease is diabetes.

24. The method of claim 22 , wherein said disease is diabetes.

25. The method of claim 23 , wherein said disease is Type II diabetes.

26. The method of claim 24 , wherein said disease is Type II diabetes.