IP Library › Granted Patent US 10,150,778
Granted Patent B2
US 10,150,778 · App. 15/481,505 · Granted Dec 11, 2018

Production method of thienopyrimidine derivative

Inventor: Kazuhiro Miwa (Osaka, JP)
Assignee: Takeda Pharmaceutical Company Limited
C07D495/04C07D333/38C07D409/12
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Quick Facts
Patent No.
US 10,150,778
App. No.
15/481,505
Granted
Dec 11, 2018
Kind
B2
Abstract

The present invention provides a production method of a thienopyrimidine derivative or a salt thereof which has a gonadotropin releasing hormone (GnRH) antagonistic action with high quality in high yield. The present invention provides a method of producing a thienopyrimidine derivative, which comprises reacting 6-(4-aminophenyl)-1-(2,6-difluorobenzyl)-5-dimethylaminomethyl-3-(6-methoxypyridazin-3-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione or salt thereof, 1,1′-carbonyldiimidazole or a salt thereof and methoxyamine or a salt thereof, and the like.

Claims (3)

1. A compound represented by the formula (I):

wherein R 1 is a hydroxy group, a C 1-6 alkoxy group or a C 1-6 alkoxy-pyridazinylamino group, or a salt thereof.

2. The compound of claim 1 , wherein R 1 is 6-methoxy-3-pyridazinylamino group or a salt thereof.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 7, 2017
From: FUKUOKA, KOICHIRO; MIWA, KAZUHIRO; SASAKI, TSUYOSHI; KOMURA, FUMIYA
To: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Reel/Frame 043523/0796 →
Priority Claims (1)
JP 2012-217679 · Sep 28, 2012 · national
Continuity (2)
Division 14432188
Related Publication 20170210753A1 · Jul 27, 2017
Cited By (6)
US 12,325,714 US 12,336,990 US 12,338,249 US 12,551,447 US 12,629,370 US 12,655,154