Kinetin/zeatin topical formulation
The solubility of kinetin and/or of zeatin is increased when either or both are combined in a formulation that includes a polyoxyalkylene-n-glycerol dicarboxylate component and a fatty acid component. These two components provide a synergistic increase in the solubility of kinetin and/or zeatin that is greater than that which would be expected based on the solubility of kinetin and zeatin in the individual components.
1. A formulation comprising kinetin and/or zeatin in which the kinetin and/or zeatin is contained as part of a liposome and wherein the kinetin and zeatin do not precipitate from the formulation in the presence of water, wherein the formulation comprises a polyoxyalkylene-n-glycerol dicarboxylate component and a fatty acid component.
2. The formulation of claim 1 , wherein the amounts of the polyoxyalkylene-n-glycerol dicarboxylate component and the fatty acid component are sufficient to provide a synergistic increase in the solubility of the kinetin and/or the zeatin in the formulation.
3. The formulation of claim 1 , wherein the polyoxyalkylene of the polyoxyalkylene-n-glycerol dicarboxylate component is selected from the group consisting of paraformaldehyde, polyethylene glycol, polypropylene glycol, and polytetramethylene glycol.
4. The formulation of claim 1 , wherein the glyceryl dicarboxylate of the polyoxyalkylene-n-glycerol dicarboxylate component is selected from the group consisting of glyceryl dilaurate, glyceryl diarachidate, glyceryl dibehenate, glyceryl dierucate, glyceryl dihydroxystearate, glyceryl diisopalmitate, glyceryl diisostearate, glyceryl dilinoleate, glyceryl dimyristate, glyceryl dioleate, glyceryl diricinoleate, glyceryl dipalmitate, glyceryl dipalmitoleate, glyceryl distearate, glyceryl palmitate lactate, glyceryl stearate citrate, glyceryl stearate lactate, and glyceryl stearate succinate.
5. The formulation of claim 1 , wherein the fatty acid component comprises one or more fatty acids that are liquid at room temperature or that have a branched or unbranched chain of 12 to 20 carbons.
6. The formulation of claim 5 , wherein the fatty acid component comprises a mixture of fatty acids.
7. The formulation of claim 6 , wherein the fatty acid component is a mixture of branched and straight-chain unsaturated C18 fatty acids.
8. The formulation of claim 7 , wherein the fatty acid component is a mixture of fatty acids having between 12 and 20 carbons.
9. The formulation of claim 7 , wherein the fatty acid component is a mixture of fatty acids comprising branched and straight chain fatty acids.
10. The formulation of claim 7 , wherein the fatty acid component is a mixture of fatty acids comprising saturated and unsaturated fatty acids.
11. The formulation of claim 1 , wherein the polyoxyalkylene-n-glycerol dicarboxylate component is PEG-12 Glycerol dimyristate or PEG-12 Glycerol dioleate.
12. The formulation of claim 1 , wherein the fatty acid component is isostearic acid.
13. The formulation of claim 1 , wherein the polyoxyalkylene-n-glycerol dicarboxylate component is PEG-12 Glycerol dimyristate or PEG-12 Glycerol dioleate, and the fatty acid component is isostearic acid.
14. The formulation of claim 1 , wherein the formulation comprises only kinetin.
15. The formulation of claim 1 , wherein the formulation comprises only zeatin.
16. The formulation of claim 1 , wherein the formulation comprises both kinetin and zeatin.
17. A formulation comprising kinetin and/or zeatin in which the kinetin and/or zeatin is contained as part of a liposome, wherein the formulation includes a polyoxyalkylene-n-glycerol dicarboxylate component and a fatty acid component, wherein the amounts of the polyoxyalkylene-n-glycerol dicarboxylate and the fatty acid are sufficient to provide a synergistic increase in the solubility of the kinetin and/or the zeatin in the formulation.
18. A method of delivering kinetin and/or zeatin to a subject in need thereof, said method comprising administering to the skin of the subject a formulation of claim 1 .