Treating critically ill patients with intravenous ibuprofen
Methods of treating at least one condition chosen from pain, inflammation, and fever in a critically ill patient in need thereof, comprising administering to the critically ill patient an intravenous pharmaceutical composition comprising ibuprofen using a first dosage regimen, wherein the first dosage regimen produces a first pharmacokinetic profile in critically ill patients that is about equivalent to a second pharmacokinetic profile produced by administration of the intravenous pharmaceutical composition using a second dosage regimen of ibuprofen to non-critically ill patients, wherein the at least one condition of the critically ill patient is thereby treated.
1. A method of treating pain in critically ill patients in need thereof, comprising intravenously administering to critically ill patients an ibuprofen pharmaceutical composition comprising a dose of about 800 mg ibuprofen about every 4 to about 6 hours to treat pain in said patients to attain a mean Cmax from about 80% to about 125% of about 60 μg/ml, wherein the critically ill patients are not being treated for inflammation and are receiving at least one of the following: vasopressor support treatment, mechanical ventilation treatment, large volumes of blood products, have a pulmonary artery catheter treatment, an arterial blood pressure catheter treatment inserted, are being treated in an Intensive Care Unit, packed red blood cells administration, and multiple antibiotics administration; and pain is thereby treated.
2. The method of claim 1 , wherein the dose of intravenous ibuprofen administered provides a mean (AUC) within about 80% to about 125% of 94 μg.h/ml.
3. The method of claim 2 , wherein the critically ill patients are patients who are being treated in an Intensive Care Unit.
4. A method of treating pain in critically ill patients in need thereof, comprising intravenously administering to critically ill patients an ibuprofen pharmaceutical composition comprising a dose of about 400 mg ibuprofen about every 4 to about 6 hours to treat pain in said patients to attain a mean Cmax from about 80% to about 125% of about 25.7 μg/ml, wherein the critically ill patients are not being treated for inflammation and are receiving at least one of the following: vasopressor support treatment, mechanical ventilation treatment, large volumes of blood products, have a pulmonary artery catheter treatment, an arterial blood pressure catheter treatment inserted, are being treated in an Intensive Care Unit, packed red blood cells administration, and multiple antibiotics administration; and pain is thereby treated.
5. The method of claim 4 , wherein the dose of intravenous ibuprofen administered provides a mean (AUC) within about 80% to about 125% of 45.9 μg.h/ml.
6. The method of claim 4 , wherein the critically ill patients are patients who are being treated in an Intensive Care Unit.
7. The method of claim 5 , wherein the critically ill patients are patients who are being treated in an Intensive Care Unit.