Methods of treating cancer
The present invention relates to methods of treating or preventing cancer in a subject in need thereof comprising administering a therapeutically effective amount of a compound of the invention.
1. A method of treating or preventing hepatocellular carcinoma in a subject in need thereof comprising administering a therapeutically effective amount of Compound 1:
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the hepatocellular carcinoma is selected from the group consisting of early stage hepatocellular carcinoma, non-metastatic hepatocellular carcinoma, primary hepatocellular carcinoma, advanced hepatocellular carcinoma, locally advanced hepatocellular carcinoma, metastatic hepatocellular carcinoma, hepatocellular carcinoma in remission, or recurrent hepatocellular carcinoma.
3. The method of claim 1 , wherein the FXR agonist is the sodium salt of Compound 1.
4. The method of claim 1 , wherein the FXR agonist is the N,N-diethylethaneamine salt of Compound 1.
5. A method of treating or preventing hepatocellular carcinoma in a subject in need thereof comprising administering a pharmaceutical composition comprising a therapeutically effective amount of FXR agonist selected from Compound 1:
or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient.
6. A kit for treating or preventing hepatocellular carcinoma in a subject in need thereof comprising Compound 1:
or a pharmaceutically acceptable salt thereof.