TREATMENT OF CANCER WITH HYPOCHLOROUS ACID
The present invention relates to hypochlorous acid compositions and their use in therapy for cancer patients.
1 . A method for treating immune or inflammatory processes associated with cancer or cancer therapy in a patient, comprising administering to a patient an effective amount of a hypochlorous acid composition.
2 . The method of claim 1 , wherein the patient is undergoing a cancer therapy selected from cancer immune therapy, resection, chemotherapy, radiation therapy, or a combination thereof.
3 . (canceled)
4 . The method of claim 2 , wherein the patient receives an immune checkpoint inhibitor that targets CTLA-4, PD-1 or PD-1L, LAG3, TIM3, or KIR.
5 . The method of claim 4 , wherein the immune checkpoint inhibitor is nivolumab, pembrolizumab, or ipilimumab.
6 . The method of claim 2 , wherein the patient receives an immune stimulating therapy that targets ICOS, GITR, OX40, CD137, CD122, or CD27.
7 . (canceled)
8 . The method of claim 1 , wherein the patient is undergoing chemotherapy, radiation therapy, or a combination thereof.
9 . The method of claim 8 , wherein the patient suffers a side effect selected from skin rash, dry and/or itchy skin, hives, sensitivity to light, burning and painful skin, skin hardening (scleroderma), skin lesions, skin ulcers or sores, necrotic wounds, and malignant wounds.
10 . The method of claim 8 , wherein the patient suffers from mucosal lesions, which is optionally oral mucositis.
11 . The method of claim 8 , wherein the patient suffers from a side effect selected from dry eye syndrome, cataracts, conjunctivitis, and eye itch.
12 - 13 . (canceled)
14 . The method of claim 1 , wherein the cancer is skin cancer, breast cancer, lung cancer, testicular cancer, cervical cancer, uterine cancer, lymphoma, thyroid cancer, lymphoma, sinus cancer, or lip or oral cancer.
15 . (canceled)
16 . The method of claim 1 , wherein the cancer is prostate cancer, kidney cancer, brain cancer, ovarian cancer, colon cancer, bladder cancer, pancreatic cancer, stomach cancer, esophageal cancer, liver cancer, mesothelioma, parathyroid cancer, penile cancer, rectal cancer, or cancer of the small intestine.
17 . A method for treating a pre-cancerous lesion, comprising, administering to a patient an effective amount of a hypochlorous acid composition to inhibit development of the lesion into cancer.
18 . The method of claim 1 , wherein the hypochlorous acid composition is administered topically.
19 . The method of claim 1 , wherein the hypochlorous acid composition is administered by injection, or by application to cancer-affected organs and/or tissues.
20 - 23 . (canceled)
24 . The method of claim 1 , wherein the hypochlorous acid composition has from about 10 to about 100 mM HOCl.
25 - 26 . (canceled)
27 . The method of claim 1 , wherein the hypochlorous acid composition is administered at least daily.
28 . The method of claim 1 , wherein the hypochlorous acid composition is administered for at least 4 weeks.