Controlled sympathectomy and micro-ablation systems and methods
A catheter system for controlled sympathectomy procedures is disclosed. A catheter system for controlled micro ablation procedures is disclosed. Methods for performing a controlled surgical procedure are disclosed. A system for performing controlled surgical procedures in a minimally invasive manner is disclosed.
1. A method, comprising the steps of:
applying a procedure to a first region in a vicinity of a lumen coupled to an organ in a subject via delivery of at least one of energy and a chemical to at least one of a plurality of sensing tips of a tool under control of a local control circuit, the tool comprising a delivery catheter, one or more microfingers having substantially elongate structures, the plurality of sensing tips electrically and mechanically coupled to the one or more microfingers, and the local control circuit embedded in the substantially elongate structure of at least one of the one or more microfingers, wherein the plurality of sensing tips are configured to interface with a wall of the lumen coupled to the organ on deployment of the one or more microfingers from the delivery catheter;
subsequently applying a follow on procedure to a second region in the vicinity of the lumen via delivery of at least one of energy and a chemical to at least one of the plurality of sensing tips under control of the local control circuit, the second region being equidistant or closer to the organ than the first region;
monitoring one or more physiologic parameters of the subject utilizing at least one of the plurality of sensing tips after application of the follow on procedure;
conditioning one or more signals representing the monitored physiologic parameters utilizing the local control circuit;
conveying the conditioned one or more signals representing the monitored physiologic parameters to a feedback system coupled to the tool;
analyzing the conditioned one or more signals utilizing the feedback system to determine one or more changes in the physiologic parameters; and
determining an outcome of the procedure based upon the determined changes in the physiologic parameters.
2. The method in accordance with claim 1 , wherein the outcome is successful if one or more of the physiologic parameters do not substantially change during a predetermined period following application of the follow on procedure.
3. The method in accordance with claim 1 , wherein the outcome is unsuccessful if one or more of the physiologic parameters substantially change during a predetermined period following application of the follow on procedure.
4. The method in accordance with claim 1 , wherein the procedure is selected from the group consisting of an ablation, an excision, a cut, a burn, a radio frequency ablation, freezing, a microwave ablation, radiosurgery, an ultrasonic ablation, an abrasion, a biopsy, and delivery of a substance.
5. The method in accordance with claim 1 , wherein the follow on procedure is selected from the group consisting of an ablation, an excision, a cut, a burn, a radio frequency ablation, freezing a microwave ablation, radiosurgery, an ultrasonic ablation, an abrasion, a biopsy, stimulation, and delivery of a substance.
6. The method in accordance with claim 1 , wherein the one or more physiologic parameters are selected from water concentration, tone, blood oxygen saturation of local tissues, evoked potential, electrolyte or solute concentration, stimulation/sensing of nervous activity, electromyography, temperature, blood pressure, vasodilation, vessel wall stiffness, muscle sympathetic nerve activity (MSNA), central sympathetic drive, a mechanomyographic signal, a local field potential, an electroacoustic event, central sympathetic drive, tissue tone, nerve traffic, and combinations thereof.
7. The method in accordance with claim 2 , wherein the predetermined period is longer than 5 seconds (s), longer than 30 s, longer than 1 minute (min), longer than 3 min, longer than 5 min, or longer than 8 min.
8. The method in accordance with claim 1 , wherein a timespan between application of the procedure and application of the follow on procedure is longer than 5 s, longer than 30 s, longer than 1 min, longer than 3 min, longer than 5 min, or longer than 8 min.
9. The method in accordance with claim 1 , further comprising applying one or more subsequent follow on procedures to at least one of the first region and the second region in the subject under control of the local control circuit based on feedback received from the feedback system.
10. The method in accordance with claim 9 , wherein the outcome is durable if one or more of the physiologic parameters do not substantially change during a predetermined period following application of the one or more of subsequent follow on procedures.
11. The method in accordance with claim 1 , further comprising monitoring electrophysiologic activity in the vicinity of one of the first region and the second region, the outcome related to changes therein.
12. The method in accordance with claim 1 , wherein the plurality of sensing tips comprise a balloon catheter comprising a balloon shaped and dimensioned for placement within the lumen.
13. The method in accordance with claim 1 , wherein one or more of the steps are provided by an ultrasound delivery system comprising the tool.
14. The method in accordance with claim 1 , further comprising monitoring the one or more physiologic parameters of the subject utilizing a pressure sensor coupled to the subject.
15. The method of claim 1 , wherein the one or more microfingers comprise a longitudinal wire cage, and further comprising placing the tool to position the longitudinal wire cage in the lumen such that a first microfinger array comprising a first subset of the plurality of sensing tips biases against the wall of the lumen in the first region while a second microfinger array comprising a second subset of the plurality of sensing tips biases against the wall of the lumen in the second region.
16. The method of claim 1 , wherein the one or more microfingers comprise a first microfinger array and a second microfinger array comprising respective radially biased flexural springs, and further comprising placing the tool such that a first subset of the plurality of sensing tips coupled to the radially biased flexural springs of the first microfinger array bias against the wall of the lumen in the first region while a second subset of the plurality of sensing tips coupled to the radially biased flexural springs of the second microfinger array bias against the wall of the lumen in the second region.
17. The method of claim 1 , further comprising positioning the delivery catheter of the tool in the lumen and deploying the one or more microfingers from the delivery catheter, the one or more microfingers being configured to bend within the body of the subject on deployment from the delivery catheter to bias towards the wall of the lumen.
18. The method of claim 1 , wherein conditioning the one or more signals representing the monitored physiologic parameters utilizing the local control circuit comprises converting one or more of the signals to digital form prior to conveying the conditioned one or more signals to the feedback system.
19. The method of claim 1 , wherein conditioning the one or more signals representing the monitored physiologic parameters comprises utilizing the local control circuit as a low impedance source.
20. The method of claim 1 , wherein conditioning the one or more signals representing the monitored physiologic parameters comprises multiplexing a networked array of the sensing tips together using the local control circuit.