(Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles
This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.
1. A method of treating pain selected from the group consisting of acute pain, visceral pain, and neuropathic pain, comprising administering to a human being an effective amount of a compound selected from the group consisting of
and a pharmaceutically acceptable salt thereof, to treat the pain.
2. The method of claim 1 , wherein the compound is
3. The method of claim 1 , wherein the pain is acute pain.
4. The method of claim 2 , wherein the pain is acute pain.
5. The method of claim 3 , wherein the acute pain is trigeminal neuralgia.
6. The method of claim 4 , wherein the acute pain is trigeminal neuralgia.
7. The method of claim 1 , wherein the pain is visceral pain.
8. The method of claim 2 , wherein the pain is visceral pain.
9. The method of claim 1 , wherein the pain is neuropathic pain.
10. The method of claim 2 , wherein the pain is neuropathic pain.
11. The method of claim 9 , wherein the neuropathic pain is post-herpetic neuralgia.
12. The method of claim 10 , wherein the neuropathic pain is post-herpetic neuralgia.
13. The method of claim 9 , wherein the neuropathic pain is due to multiple sclerosis.
14. The method of claim 10 , wherein the neuropathic pain is due to multiple sclerosis.
15. The method of claim 9 , wherein the neuropathic pain is due to chemotherapy caused nerve injury.
16. The method of claim 10 , wherein the neuropathic pain is due to chemotherapy caused nerve injury.
17. The method of claim 9 , wherein the neuropathic pain is due to central nervous system injury.
18. The method of claim 10 , wherein the neuropathic pain is due to central nervous system injury.
19. The method of claim 1 , wherein the compound is administered in the form of a tablet, pill, or capsule.
20. The method of claim 3 , wherein the compound is administered in the form of a tablet, pill, or capsule.
21. The method of claim 9 , wherein the compound is administered in the form of a tablet, pill, or capsule.
22. A method of treating complex regional pain syndrome type I, comprising administering to a human being an effective amount of a compound selected from the group consisting of
and a pharmaceutically acceptable salt thereof, to treat the complex regional pain syndrome type I.
23. The method of claim 22 , wherein the compound is
24. A method of treating pain due to osteoarthritis, comprising administering to a human being an effective amount of a compound selected from the group consisting of
and a pharmaceutically acceptable salt thereof, to treat the pain due to osteoarthritis.
25. The method of claim 24 , wherein the compound is