Amine-functionalized polymeric compositions for medical devices
The present disclosure provides amine-modified polymer foams, which may be used for wound dressing materials. For example, the modified materials can include a covalently attached molecule comprising free amine groups. Such amine groups can be used, for instance, to conjugate biologically active polypeptides and/or linkers. Methods for using modified polymers are also provided.
1. A wound dressing comprising an amine-functionalized polymer foam and a biologically active agent covalently attached to an amine group on the polymer foam.
2. The wound dressing of claim 1 , wherein the biologically active agent is attached to the foam through an adapter.
3. The wound dressing of claim 1 , wherein the biologically active agent is a polypeptide.
4. The wound dressing of claim 3 , wherein the polypeptide is selected from the group consisting of gelatin, collagen, albumin, an enzyme, growth factor, chemokine, cytokine, and a polypeptide that binds to any of them.
5. The wound dressing of claim 4 , wherein the polypeptide is an enzyme selected from a protease, hydrolase, lyase, ligase, isomerase, transferase, oxidase, reductase, oxidoreductase, synthase, polymerase, kinase, and phosphatase.
6. The wound dressing of claim 1 , comprising a polyurethane foam.
7. The wound dressing of claim 6 , comprising an open cell foam.
8. The wound dressing of claim 1 , wherein the amine-functionalized polymer foam comprises a polyurethane polymer copolymerized with neomycin.
9. The wound dressing of claim 1 , wherein the biologically active agent is directly attached to the functionalized polymer foam.
10. The wound dressing of claim 2 , wherein the adapter is an amine to amine crosslinker.
11. The wound dressing of claim 10 , wherein the amine-to-amine crosslinker is selected from malondialdehyde, succinaldehyde, phthalaldehyde, glutaraldehyde, and glyoxal.
12. The wound dressing of claim 11 , wherein the crosslinker is glutaraldehyde.
13. The wound dressing of claim 2 , wherein the adapter is cleavable.
14. The wound dressing of claim 7 , wherein the material comprises a foam that is a reticulated open-celled foam.
15. A method for treating a wound site, comprising:
applying a wound dressing according to claim 1 to a wound site; and
applying negative pressure to the wound site.
16. The method of claim 15 , further comprising applying an instillation solution to the wound site.
17. The method of claim 15 , wherein the biologically active agent comprises a polypeptide.
18. The method of claim 16 , wherein the instillation solution includes one or more agents that modulate a release of the biologically active agent.
19. The wound dressing of claim 1 , wherein the biologically active agent comprises a debridement enzyme.
20. The wound dressing according to claim 19 , wherein the biologically active agent is bromelain.
21. The wound dressing according to claim 19 , wherein the biologically active agent is papain.
22. The wound dressing according to claim 19 , wherein the biologically active agent is trypsin.
23. The wound dressing according to claim 19 , wherein the biologically active agent is collagenase.