Identification of consumed drugs and food by unique near infrared tag libraries
We disclose a method of tagging nutritional or drug compositions using chemical entities which are known to be safely consumed and which are detectable using known techniques, including near IR spectroscopy. The chemical entities used as tags may be detected in easily obtainable biological samples, including urine and feces. The biological sample may be deposited into a medical toilet which may analyze the biological sample using an analytical device associated with the medical toilet. The tag may be identified and quantified to then identify and quantify the nutritional or drug composition the subject consumed along with the tag. This system may be used to track the source of a food or drug, confirm compliance to a prescribed diet or drug treatment, confirm drug consumption in clinical trials, identify the source of contaminated food, and identify the food substances used to produce food products.
1. A method of tracking a consumed substance comprising the steps of:
a. analyzing a biological sample using a near infrared spectroscopy technique, wherein the biological sample is obtained from a subject who has consumed at least one drug composition, and wherein each of the at least one drug composition comprises at least one drug and at least one unique tag, and wherein the at least one unique tag is detectable by near infrared spectroscopy;
b. identifying the presence of the at least one unique tag in the biological sample; and
c. extrapolating the identification of the at least one unique tag to identify the consumed drug composition.
2. The method of claim 1 , wherein the at least one unique tag comprises one or more of polyethylene glycol, ethylene-vinyl acetate, copovidone, povidone, propylparaben, methyl paraben, acesulfame potassium, mannitol, sorbitol, xylitol, steviol glucuronide, sucralose, oleic acid, trans-anethole, 1, 8-eucalyptol, limonene-2D, linalool, citronellol, riboflavin, tartaric acid, and salts of tartaric acid.
3. The method of claim 2 , wherein the at least one unique tag comprises polyethylene glycol, and wherein the polyethylene glycol comprises polymers of one or more of the following average molecular weights: 400, 600, 800, 1000, 1500, and 2000.
4. The method of claim 2 , wherein the at least one tag comprises polyethylene glycol, and wherein the polyethylene glycol comprises polymers of an average molecular weight of between about 400 and about 2000.
5. The method of claim 2 , wherein the at least one unique tag comprises povidone, and wherein the povidone comprises one or more of the following number of monomers: 25, 30, and 90.
6. The method of claim 1 , wherein the biological sample consists of one or more of the following: urine, feces, whole blood, serum, plasma, cerebrospinal fluid, ascites, mucous, gastric gavage, saliva, breath, and breast milk.
7. The method of claim 1 , further comprising the step of quantifying the at least one unique tag by applying the intensity of the near infrared spectra reading to a standard curve.
8. The method of claim 1 , wherein the step of analyzing the biological sample using a near infrared spectroscopy technique is performed within a medical toilet, and wherein the medical toilet comprises a spectrometer.
9. The method of claim 1 , wherein steps (a), (b), and (c) are performed a plurality of times, and further comprising the step of performing a trending analysis.
10. The method of claim 1 , wherein the at least one unique tag comprises a plurality of chemicals in a unique ratio.
11. A method of tracking a consumed substance comprising the steps of:
a. analyzing a biological sample using a near infrared spectroscopy technique, wherein the biological sample is obtained from a subject who has consumed at least one nutritional composition, and wherein each of the at least one nutritional composition comprises at least one nutritional substance and at least one unique tag, and wherein the at least one unique tag is detectable by near infrared spectroscopy;
b. identifying the presence of the at least one unique tag in the biological sample; and
c. extrapolating the identification of the at least one unique tag to identify the consumed nutritional composition.
12. The method of claim 11 , wherein at least one unique tag comprises one or more of polyethylene glycol, ethylene-vinyl acetate, copovidone, povidone, propylparaben, methyl paraben, acesulfame potassium, mannitol, sorbitol, xylitol, steviol glucuronide, sucralose, oleic acid, trans-anethole, 1, 8-eucalyptol, limonene-2D, linalool, citronellol, riboflavin, tartaric acid, and salts of tartaric acid.
13. The method of claim 12 , wherein the at least one unique tag comprises polyethylene glycol, and wherein the polyethylene glycol comprises polymers of one or more of the following average molecular weights: 400, 600, 800, 1000, 1500, and 2000.
14. The method of claim 12 , wherein the at least one unique tag comprises polyethylene glycol, and wherein the polyethylene glycol comprises polymers of an average molecular weight of between about 400 and about 2000.
15. The method of claim 12 , wherein the at least one unique tag comprises povidone, and wherein the povidone comprises one or more of the following number of monomers: 25, 30, and 90.
16. The method of claim 11 , wherein the biological sample consists of one or more of the following: urine, feces, whole blood, serum, plasma, cerebrospinal fluid, ascites, mucous, gastric gavage, saliva, breath, and breast milk.
17. The method of claim 11 , further comprising the step of quantifying the at least one unique tag by applying the intensity of the near infrared spectra reading to a standard curve.
18. The method of claim 11 , wherein the step of analyzing the biological sample using a near infrared spectroscopy technique is performed within a medical toilet, wherein the medical toilet comprises a spectrometer.
19. The method of claim 11 , wherein steps (a), (b), and (c) are performed a plurality of times, and further comprising the step of performing a trending analysis.
20. The method of claim 11 , wherein the at least one unique tag comprises a plurality of tags which are present in a unique ratio.