IP Library › Granted Patent US 10,869,903
Granted Patent B2
US 10,869,903 · App. 15/495,522 · Granted Dec 22, 2020

Probiotic and prebiotic compositions, and methods of use thereof for treatment and prevention of graft versus host disease

Inventors: David Berry (Waban, MA); Noubar B. Afeyan (Lexington, MA); Johanne Kaplan (Sherborn, MA); Neal Gordon (Brookline, MA); Shaila Rahman (Cambridge, MA)
Assignee: Evelo Biosciences, Inc.
A61K35/74A61K9/0031A61K9/0053A61K9/19A61K31/7004A61K31/7016A61K31/715A61K35/39A61K35/741A61K35/742A61K35/744A61K35/745A61K35/747A61K38/46A61K2035/115Y02A50/401Y02A50/414Y02A50/473
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Quick Facts
Patent No.
US 10,869,903
App. No.
15/495,522
Granted
Dec 22, 2020
Kind
B2
Abstract

Probiotic compositions containing non-pathogenic microbial entities, e.g., bacterial or fungal entities, are described herein. The probiotic compositions may optionally contain or be used in conjunction with one or more prebiotics. Uses of the probiotic compositions to treat or prevent transplant disorders, e.g., graft-versus-host disease (GVHD), in a subject are also provided.

Claims (7)

1. A method of reducing inflammation in the gastrointestinal tract of a subject, comprising orally administering to the subject a composition comprising an isolated population of bacteria of the genus Blautia , such that inflammation in the gastrointestinal tract of the subject is reduced.

2. The method of claim 1 , wherein the composition comprises an isolated population of bacteria selected from the group consisting of Blautia ( Ruminococcus ) coccoides, Blautia faecis, Blautia glucerasea, Blautia ( Ruminococcus ) hansenii, Blautia hydrogenotrophica ( Ruminococcus hydrogenotrophicus ), Blautia ( Ruminococcus ) luti, Blautia ( Ruminococcus ) obeum, Blautia producta ( Ruminococcus productus ), Blautia ( Ruminococcus ) schinkii, Blautia stercoris, Blautia uncultured bacterium clone BKLE_a03_2 (GenBank: EU469501.1), Blautia uncultured bacterium clone SJTU_B_14_30 (GenBank: EF402926.1), Blautia uncultured bacterium clone SJTU_C_14_16 (GenBank: EF404657.1), Blautia uncultured bacterium clone S1-5 (GenBank: GQ898099.1), Blautia uncultured PAC000178_s, Blautia wexlerae , and combinations thereof.

3. The method of claim 1 , wherein the composition comprises an isolated population of bacteria from the species Blautia hydrogenotrophica.

4. The method of claim 1 , wherein the composition contains a single species of bacteria.

5. The method of claim 1 , wherein the composition does not comprise bacterial cells of the species Blautia producta.

6. The method of claim 1 , wherein the composition comprises an isolated population of bacteria from the species Blautia stercoris.

7. The method of claim 1 , wherein the composition comprises an isolated population of bacteria from the species Blautia wexlerae.

Assignments (8)
RELEASE OF SECURITY INTEREST Recorded Apr 16, 2024
From: HORIZON TECHNOLOGY FINANCE CORPORATION
To: EVELO BIOSCIENCES, INC.
Reel/Frame 067118/0419 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 16, 2024
From: EVELO BIOSCIENCES, INC.
To: PHARMABIOME AG
Reel/Frame 067120/0665 →
SECURITY INTEREST Recorded Jul 14, 2023
From: EVELO BIOSCIENCES, INC.
To: HORIZON TECHNOLOGY FINANCE CORPORATION
Reel/Frame 064274/0354 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 14, 2018
From: BERRY, DAVID; AFEYAN, NOUBAR B.
To: FLAGSHIP PIONEERING, INC. (F/K/A FLAGSHIP VENTURES MANAGEMENT, INC.)
Reel/Frame 046095/0464 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 14, 2018
From: KAPLAN, JOHANNE
To: EVELO BIOSCIENCES, INC.
Reel/Frame 046095/0476 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 14, 2018
From: GORDON, NEAL
To: EVELO BIOSCIENCES, INC.
Reel/Frame 046095/0495 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 14, 2018
From: FLAGSHIP PIONEERING, INC. (F/K/A FLAGSHIP VENTURES MANAGEMENT, INC.)
To: EVELO BIOSCIENCES, INC.
Reel/Frame 046095/0506 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 27, 2018
From: RAHMAN, SHAILA
To: FLAGSHIP PIONEERING, INC. (F/K/A FLAGSHIP VENTURES MANAGEMENT, INC.)
Reel/Frame 045661/0894 →
Continuity (10)
Continuation 14952892 · Nov 25, 2015
Provisional Application 62257714 · Nov 19, 2015
Provisional Application 62162562 · May 15, 2015
Provisional Application 62117632 · Feb 18, 2015
Provisional Application 62117637 · Feb 18, 2015
Provisional Application 62117639 · Feb 18, 2015
Provisional Application 62084536 · Nov 25, 2014
Provisional Application 62084537 · Nov 25, 2014
Provisional Application 62084540 · Nov 25, 2014
Related Publication 20180071344A1 · Mar 15, 2018