Acceleration of Reconstitution of Plasma Powder by Mixing with Small Beads
Methods of accelerating the reconstitution of plasma powder by mixing the powder with small beads is disclosed. The beads can be, for example, glass and/or plastic resin beads having a diameter from about 2 mm to about 6 mm. The plasma powder can be, for example, a spray-dried plasma powder. A method is provided of accelerating the reconstitution of a dry protein powder in a fluid that includes, but is not limited to, the steps of providing both a dry protein powder and small beads in a container, adding a reconstitution fluid to the container, and manipulating the dry protein powder and the small beads to dissolve the dry protein powder in the reconstitution fluid.
1 . A method for accelerating reconstitution of a dry protein powder in a fluid, the method comprising:
a) providing a dry protein powder in a container and adding small beads to the dry protein powder in the container or providing small beads in a container and adding a dry protein powder to the small beads in the container;
b) adding a reconstitution fluid to the container; and
c) manipulating the dry protein powder and the small beads to dissolve the dry protein powder in the reconstitution fluid.
2 . The method of claim 1 , wherein the dry protein powder is spray-dried plasma powder.
3 . The method of claim 2 , wherein there are approximately 600 to approximately 1300 small beads for every approximately 16 grams of spray-dried plasma powder.
4 . The method of claim 1 , wherein manipulating the dry protein powder and the small beads is performed by manipulating the powder and the beads from the outside of the container.
5 . The method of claim 1 , wherein the container is a plastic bag.
6 . The method of claim 5 , wherein the plastic bag is a plasma bag.
7 . The method of claim 1 , wherein the small beads comprise at least one material selected from the group consisting of glass and plastic resin.
8 . The method of claim 7 , wherein the small beads comprise at least one material selected from the group consisting of polycarbonate, polypropylene, polyvinyl chloride, cellulose acetate, and borosilicate glass.
9 . The method of claim 1 , wherein the small beads are approximately spherical or approximately oval.
10 . The method of claim 1 , wherein the small beads have diameters from about 2 mm to about 6 mm.
11 . The method of claim 10 , wherein the small beads have diameters from about 2 mm to about 4 mm.
12 . The method of claim 10 , wherein the small beads have diameters from about 4 mm to about 5 mm.
13 . The method of claim 1 , wherein the small beads are pre-sterilized.
14 . The method of claim 1 , wherein adding the reconstitution fluid to the container wets substantially all of the dry protein powder.
15 . A composition comprising small beads with a diameter from about 2 mm to about 6 mm and a dry protein powder.
16 . The composition of claim 15 , wherein the dry protein powder is spray-dried plasma powder.
17 . The composition of claim 15 , wherein the composition is in a plasma bag.
18 . The composition of claim 15 , wherein the small beads comprise at least one material selected from the group consisting of glass and plastic resin.
19 . The composition of claim 18 , wherein the small beads comprise at least one material selected from the group consisting of polycarbonate, polypropylene, polyvinyl chloride, cellulose acetate, and borosilicate glass.