Enantiopure or enantioenriched BDDE and its use as crosslinking agent in the manufacture of cross-linked products
Enantiomers of butanediol diglycidyl ether (BDDE) are present in an enantiomerically enriched enantioenriched mixture of BDDE stereisomers or in an enantiomerically pure BDDE. Enantiomerically enriched or pure BDDE is useful as a cross-linking agent, such as in the preparation of a cross-linked hyaluronic acid product.
1. A process for preparing a cross-linked hyaluronic acid product, comprising the step of cross-linking a hyaluronic acid using an enantioenriched mixture of BDDE stereoisomers, wherein one of the following enantiomers of BDDE is present in a percentage share of at least 50%:
as cross-linking agent.
2. A cross-linked hyaluronic acid product, wherein the product is produced by cross-linking a hyaluronic acid with an enantioenriched mixture of BDDE stereoisomers according to the process of claim 1 .
3. A cross-linked product according to claim 2 , wherein the cross-linked product is cross-linked via ether bonds to the BDDE.
4. A cross-linked product according to claim 2 , wherein the cross-linked product is cross-linked via ester bonds to the BDDE.
5. A cross-linked product according to claim 2 , wherein the cross-linked product is cross-linked via a mixture of ether and ester bonds to the BDDE.
6. A cross-linked product according to claim 2 , wherein the cross-linked product is a gel.
7. A cross-linked product according to claim 2 , wherein the cross-linked product is a dermal filler product.