COMPOSITIONS AND METHODS FOR MITIGATING SKIN IRRITATION
Methods and compositions for decreased irritation of mammalian skin cells are provided. Compositions contain at least one amide-functionalized oligopeptide. The compositions may advantageously be applied to mammalian skin to effect a reduction in inflammation and redness experienced by the skin, and/or to reduce skin irritation.
1 . A composition comprising at least one amide-functionalized oligopeptide.
2 . The composition of claim 1 , wherein the amide-functionalized oligopeptide includes 12 amino acid moieties or less.
3 . The composition of claim 1 , wherein the amide-functionalized oligopeptide includes 10 amino acid moieties or less.
4 . The composition of claim 1 , wherein the amide-functionalized oligopeptide includes 8 amino acid moieties or less.
5 . The composition of claim 1 , wherein the amide-functionalized oligopeptide includes at least 6 amino acid moieties.
6 . The composition of claim 1 , wherein the amide-functionalized oligopeptide is an amide-functionalized acetyl hexapeptide.
7 . The composition of claim 1 , wherein the functionalized acetyl hexapeptide is selected from the group consisting of acetyl hexapeptide-1, acetyl hexapeptide-7, acetyl hexapeptide-8, acetyl hexapeptide-19, acetyl hexapeptide-20, acetyl hexapeptide-22, acetyl hexapeptide-24, acetyl hexapeptide-30, acetyl hexapeptide-31, acetyl hexapeptide-37, acetyl hexapeptide-38, acetyl hexapeptide-39, and acetyl hexapeptide-46, acetyl hexapeptide-49, and acetyl hexapeptide-51.
8 . The composition of claim 1 , wherein the amide-functionalized acetyl hexapeptide is acetyl hexapeptide-51 amide.
9 . The composition of claim 1 , wherein the composition further comprises a cosmetically or pharmaceutically acceptable carrier.
10 . The composition of claim 1 , wherein the composition produces less skin irritation, when topically applied to mammalian skin, compared to the same composition but not including the amide-functionalized oligopeptide.
11 . The composition of claim 9 , wherein the carrier comprises:
at least one vegetal wax,
at least one olive derivative or extract, and
optionally, at least one emulsifier.
12 . The composition of claim 11 , wherein the vegetal wax is a blend of cetyl palmitate, sorbitan palmitate, and sorbitan olivate.
13 . The composition of claim 11 , wherein the olive derivative or extract is a blend of ceteraryl olivate and sorbitan olivate.
14 . The composition of claim 11 , wherein the emulsifier is glyceryl stearate.
15 . The composition of claim 1 , wherein the amount of amide-functionalized oligopeptide is from about 0.06 to about 100 ppm, based upon the total weight of the composition.
16 . (canceled)
17 . A method for reducing the irritancy potential of a skin cleanser or skin sanitizer composition, the method comprising the steps of:
combining a skin cleansing or skin sanitizer composition with one or more amide-functionalized oligopeptides, wherein the amide-functionalized oligopeptide reduces the irritancy potential of the composition.
18 - 20 . (canceled)
21 . A method for the cleansing and/or sanitizing skin, the method comprising the steps of:
combining a skin cleansing or skin sanitizing composition with one or more amide-functionalized oligopeptides, wherein the amide-functionalized oligopeptide reduces the irritancy potential of the composition; and
contacting the skin with the reduced-irritancy composition in a manner sufficient to cleanse and/or sanitize the skin.
22 - 33 . (canceled)