Compositions and methods for treatment of pre-cancerous skin lesions
The present disclosure encompasses compositions and methods for the treatment of precancerous skin lesions. Compositions of the invention comprise a cytotoxic agent and a thymic stromal lymphopoietin (TSLP) inducer.
1. A method to treat actinic keratosis in a subject in need thereof, the method comprising topically administering to the subject a composition comprising about 2% to about 5% (wt/wt) 5-fluorouracil (5-FU) and a thymic stromal lymphopoietin (TSLP) inducer, wherein the TSLP inducer is about 0.002% to about 0.005% (wt/wt) calcipotriol.
2. The method of claim 1 , wherein the composition is administered twice a day for 4 to 6 days.
3. A method to prevent the transition of a precancerous skin lesion to skin cancer in a subject in need thereof, the method comprising:
a) identifying a subject with one or more precancerous skin lesion(s); and
b) topically administering to the precancerous skin lesion(s) a composition comprising about 2% to about 5% (wt/wt) 5-fluorouracil (5-FU) and a thymic stromal lymphopoietin (TSLP) inducer, wherein the TSLP inducer is about 0.002% to about 0.005% (wt/wt) calcipotriol.
4. The method of claim 3 , wherein the precancerous skin lesion is actinic keratosis and the skin cancer is squamous cell carcinoma.
5. The method of claim 3 , wherein the composition is administered twice a day for 4 to 6 days.