Triazole compounds as T-type calcium channel blockers

1. A compound of formula (I)

wherein

X represents a ring carbon or a ring nitrogen atom;

R 1 represents

(C 2-6 )alkyl;

(C 2-4 )alkyl mono-substituted with cyano, or (C 1-3 )alkoxy;

(C 1-4 )fluoroalkyl;

(C 1-3 )fluoroalkoxy;

pentafluoro-sulfanyl;

(C 3-6 )cycloalkyl-L 1 - wherein

said (C 3-6 )cycloalkyl optionally contains one ring oxygen atom; wherein said (C 3-6 )cycloalkyl is unsubstituted; or mono-substituted with fluoro, (C 1-3 )alkyl, (C 1-3 )alkoxy, hydroxy, cyano, or (C 1-3 )fluoroalkyl; or di-substituted with fluoro, or tri-substituted with two fluoro substituents and a (C 1-3 )alkyl substituent; and

the linker L 1 represents a direct bond, (C 1-2 )alkylene, oxygen, or (C 1-2 )alkylene-oxy;

5- or 6-membered heteroaryl, independently optionally mono-substituted with (C 1-3 )alkyl;

—NR 11 R 12 , wherein

R 11 and R 12 independently represent hydrogen, (C 1-3 )alkyl, (C 2-3 )fluoroalkyl, (C 3-6 )cycloalkyl, (C 3-6 )cycloalkyl mono- or di-substituted with fluoro, (C 3-6 )cycloalkyl-(C 1-3 )alkyl, (C 1-3 )alkoxy-(C 2-3 )alkyl;

or R 11 and R 12 , together with the nitrogen atom to which they are attached to, form a 4- to -6 membered ring which is optionally mono- or di-substituted with fluoro; a 2-oxo-pyrrolidinyl group; or a morpholinyl group;

and (R 4 ) n represents one or two optional substituents independently selected from (C 1-4 )alkyl, (C 1-4 )alkoxy, (C 1-3 )fluoroalkyl, (C 1-3 )fluoroalkoxy, halogen, and cyano;

or R 1 together with (R 4 ) n forms a non-aromatic 5- or 6-membered ring which is fused to the phenyl/pyridine ring; wherein said 5- or 6-membered ring optionally contains one or two heteroatoms independently selected from oxygen and nitrogen; wherein said fused 5- or 6-membered non-aromatic ring independently is optionally further mono-substituted with oxo; or di-, tri-, or tetra-substituted wherein one substituent is oxo and the remaining are (C 1-3 )alkyl;

or R 1 together with (R 4 ) n forms an aromatic 5- or 6-membered ring which is fused to the phenyl/pyridine ring; wherein said 5- or 6-membered ring optionally contains one or two nitrogen atoms, wherein said fused 5- or 6-membered aromatic ring independently is optionally further mono- or di-substituted wherein the substituents are independently selected from (C 1-4 )alkyl, (C 3-6 )cycloalkyl, (C 1 )fluoroalkyl, or cyano;

Y represents a ring carbon or a ring nitrogen atom; and

R 2 represents (C 1-4 )alkyl; (C 3-6 )cycloalkyl; (C 1-4 )alkoxy; (C 3-6 )cycloalkyl-oxy; (C 1-3 )fluoroalkyl; (C 1-3 )fluoroalkoxy; (C 1-3 )alkoxy-(C 2-3 )alkoxy; halogen; cyano; or —NR 21 R 22 , wherein R 21 and R 22 independently represent hydrogen, or (C 1-3 )alkyl, or R 21 and R 22 , together with the nitrogen atom to which they are attached to, form a 4- to -6 membered ring optionally mono- or di-substituted with fluoro, or a morpholinyl group;

and

(R 5 ) m represents one or two optional substituents independently selected from (C 1-4 )alkyl; (C 3-6 )cycloalkyl; (C 1-4 )alkoxy; halogen; cyano; (C 1-3 )fluoroalkyl; and (C 1-3 )fluoroalkoxy;

or a salt of such a compound.

2. A compound according to claim 1 , wherein X represents a ring carbon atom; or a salt of such a compound.

3. A compound according to claim 1 , wherein

R 1 represents

(C 2-6 )alkyl;

(C 2-4 )alkyl mono-substituted with cyano, or (C 1-3 )alkoxy;

(C 1-4 )fluoroalkyl;

(C 1-3 )fluoroalkoxy;

pentafluoro-sulfanyl;

(C 3-6 )cycloalkyl-L 1 - wherein

said (C 3-6 )cycloalkyl optionally contains one ring oxygen atom; wherein said (C 3-6 )cycloalkyl is unsubstituted, or mono-substituted with fluoro, (C 1-3 )alkyl, (C 1-3 )alkoxy, hydroxy, cyano, or (C 1-3 )fluoroalkyl, or di-substituted with fluoro, or tri-substituted with two fluoro substituents and a (C 1-3 )alkyl substituent; and

the linker L 1 represents a direct bond, (C 1-2 )alkylene, oxygen, or (C 1-2 )alkylene-oxy;

—NR 11 R 12 , wherein

R 11 and R 12 independently represent hydrogen, (C 1-3 )alkyl, (C 2-3 )fluoroalkyl, (C 3-6 )cycloalkyl, (C 3-6 )cycloalkyl mono- or di-substituted with fluoro, (C 3-6 )cycloalkyl-(C 1-3 )alkyl;

or R 11 and R 12 , together with the nitrogen atom to which they are attached to, form an azetidinyl or a pyrrolidinyl ring, both independently optionally mono- or di-substituted with fluoro;

and (R 4 ) n represents one optional substituent selected from (C 1-4 )alkyl, (C 1-4 )alkoxy, (C 1-3 )fluoroalkyl, (C 1-3 )fluoroalkoxy, halogen, and cyano;

or R 1 together with (R 4 ) n forms a non-aromatic 5- or 6-membered ring which is fused to the phenyl/pyridine ring to form a bicyclic ring system; wherein said bicyclic ring system is selected from 2,3-dihydro-benzooxazolyl, 3,4-dihydro-2H-benzo[1,4]oxazinyl, 2,3-dihydro-1H-indolyl, and 2,3-dihydro-benzofuranyl; wherein said non-aromatic 5- or 6-membered ring part of said bicyclic ring system independently is optionally further mono-substituted with oxo; or di-, tri-, or tetra-substituted wherein one substituent is oxo and the remaining are (C 1-3 )alkyl;

or R 1 together with (R 4 ) n forms an aromatic 5- or 6-membered ring which is fused to the phenyl/pyridine ring to form a bicyclic aromatic ring system selected from pyrazolo[3,4-b]pyridinyl, pyrrolo[2,3-b]pyridinyl, indolyl, indazolyl, quinoxalinyl, benzoimidazolyl, and quinolinyl; wherein said fused 5- or 6-membered aromatic ring part of said aromatic bicyclic ring system independently is optionally further mono- or di-substituted wherein the substituents are independently selected from (C 1-3 )alkyl, (C 3-6 )cycloalkyl, (C 1 )fluoroalkyl, or cyano;

or a salt of such a compound.

4. A compound according to claim 1 , wherein

R 1 represents

(C 2-6 )alkyl;

(C 1-4 )fluoroalkyl;

(C 1-3 )fluoroalkoxy;

(C 3-6 )cycloalkyl wherein

said (C 3-6 )cycloalkyl optionally contains one ring oxygen atom; wherein said (C 3-6 )cycloalkyl is mono-substituted with fluoro or (C 1-3 )fluoroalkyl, or di-substituted with fluoro; or

(C 3-6 )cycloalkyl-oxy- wherein

said (C 3-6 )cycloalkyl optionally contains one ring oxygen atom; wherein said (C 3-6 )cycloalkyl is unsubstituted, or di-substituted with fluoro;

and (R 4 ) n represents one optional substituent selected from (C 1-4 )alkyl, or halogen;

or a salt of such a compound.

5. A compound according to claim 1 , wherein the fragment

represents 4-isopropyl-phenyl, 4-dimethylamino-phenyl, 4-trifluoromethyl-phenyl, 4-tert.-butyl-phenyl, 4-(1-methoxy-ethyl)-phenyl, 4-(cyclopropyl-oxy)-phenyl, 4-(oxetan-3-yl)-phenyl, 4-(3-fluoro-oxetan-3-yl)-phenyl, 4-(cyclobutyl-oxy)-phenyl, 4-(3-methyl-oxetan-3-yl)-phenyl, 4-(1-cyano-cyclopropyl)-phenyl, 4-(1-cyano-1-methyl-ethyl)-phenyl, 4-(pentafluoro-sulfanyl)-phenyl, 3-methyl-4-(2,2,2-trifluoroethoxy)-phenyl, 4-(3-methoxy-oxetan-3-yl)-phenyl, 4-(oxetan-3-yl-methoxy)-phenyl, 4-(2-trifluoromethyl-cyclopropyl)-phenyl, 4-(1-trifluoromethyl-cyclopropyl)-phenyl, 4-((3-fluoro-oxetan-3-yl)-methoxy)-phenyl, 4-((3-methyl-oxetan-3-yl)-methoxy)-phenyl, 4-(3,3-difluoro-cyclobutyl-oxy)-phenyl, 4-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-phenyl, 4-((3,3-difluoro-cyclobutyl)-methoxy)-phenyl, 4-((3,3-difluoro-1-methyl-cyclobutyl)-methoxy)-phenyl; 2-(pyrrolidin-1-yl)-pyridin-5-yl, 2-(cyclopropyl(methyl)amino)-pyridin-5-yl, 2-(diethylamino)-pyridin-5-yl, 3-fluoro-2-(pyrrolidin-1-yl)-pyridin-5-yl, 2-((cyclopropylmethyl)-methyl-amino)-pyridin-5-yl, 2-(3,3-difluoro-pyrrolidin-1-yl)-pyridin-5-yl; 3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl, 1,3,3-trimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl, 1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl, 1H-indol-5-yl, 1H-indol-6-yl, 1-methyl-1H-indazol-5-yl, 1-methyl-1H-indazol-6-yl, 1-ethyl-1H-indazol-5-yl, 1,3-dimethyl-1H-indazol-5-yl, 1-propyl-1H-indazol-5-yl, 1-isopropyl-1H-indazol-5-yl, 1-butyl-1H-indazol-5-yl, 3-butyl-1H-indazol-5-yl, 3-trifluoromethyl-1H-indazol-5-yl, 3-cyclopropyl-1H-indazol-5-yl, 3-cyclopropyl-1-methyl-1H-indazol-5-yl, 1-methyl-1H-indol-5-yl, 2-methyl-1H-indol-5-yl, 1,3-dimethyl-1H-indol-5-yl, or 1,3-dimethyl-1H-indol-6-yl;

or a salt of such a compound.

6. A compound according to claim 1 , wherein

Y represents a ring carbon or a nitrogen atom;

R 2 represents (C 1-4 )alkyl; (C 1-4 )alkoxy; (C 1-3 )fluoroalkyl; (C 1-3 )fluoroalkoxy; (C 1-3 )alkoxy-(C 2-3 )alkoxy; halogen; or cyano; and

(R 5 ) m represents one or two optional substituents independently selected from (C 1-4 )alkyl; (C 1-4 )alkoxy; halogen; cyano; (C 1-3 )fluoroalkyl; and (C 1-3 )fluoroalkoxy;

or a salt of such a compound.

7. A compound according to claim 1 , wherein

Y represents a ring nitrogen atom; and

R 2 represents cyano; and

(R 5 ) m is absent; or

Y represents a ring carbon atom; and

R 2 represents (C 1-4 )alkyl; (C 1-4 )alkoxy; (C 1-3 )fluoroalkoxy; (C 1-3 )alkoxy-(C 2-3 )alkoxy; halogen; or cyano; and

(R 5 ) m represents one or two optional substituents independently selected from (C 1-4 )alkyl; (C 1-4 )alkoxy; halogen; and cyano;

or a salt of such a compound.

8. A compound according to claim 1 , wherein the fragment

represents 4-fluorophenyl, 4-methylphenyl, 4-fluoro-3-cyano-phenyl, 3,4-difluorophenyl, 3,5-difluoro-4-methoxy-phenyl, 3-fluoro-4-methoxy-phenyl, 4-cyano-3-fluoro-phenyl, 4-cyano-3-methyl-phenyl, 3-cyano-4-methyl-phenyl, 4-methoxyphenyl, 4-ethoxyphenyl, 3,4-dimethoxyphenyl, 4-fluoro-3-methoxy-phenyl; 3,4-difluoro-5-methoxy-phenyl, 3-cyano-4-methoxy-phenyl, 4-cyano-3-methoxy-phenyl, 4-cyano-3-fluoro-5-methoxy-phenyl, 4-cyanophenyl, 4-(2-methoxy-ethoxy)-phenyl, 4-difluoromethoxy-phenyl, 4-trifluoromethoxy-phenyl, 3-fluoro-4-difluoromethoxy-phenyl; 3-fluoro-4-trifluoromethoxy-phenyl; or 5-cyano-pyridin-2-yl;

or a salt of such a compound.

9. A compound according to claim 1 selected from the group consisting of N-[2-(4-Fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide;

2-(4-Dimethylamino-phenyl)-N-[2-(4-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide; N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide;

N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;

N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indol-5-yl)-acetamide;

N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1H-indol-6-yl)-acetamide;

2-(4-Cyclobutoxy-phenyl)-N-[2-(3,4-difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

2-(4-Cyclopropoxy-phenyl)-N-[2-(3,4-difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

2-[6-(Cyclopropyl(methyl)amino)-pyridin-3-yl]-N-[2-(3,4-difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

2-[6-(Cyclopropylmethyl-methyl-amino)-pyridin-3-yl]-N-[2-(3,4-difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-methoxy-ethyl)-phenyl]-acetamide;

N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-yl)-phenyl]-acetamide;

N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1H-indol-5-yl)-acetamide;

2-(6-Diethylamino-pyridin-3-yl)-N-[2-(3,4-difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[6-(3,3-difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-acetamide;

N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;

N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3,3-trimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-acetamide;

N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methoxy-oxetan-3-yl)-phenyl]-acetamide;

N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-acetamide;

N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methyl-oxetan-3-yl)-phenyl]-acetamide;

N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-oxetan-3-yl-phenyl)-acetamide; 2-(4-Isopropyl-phenyl)-N-[2-(4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

2-(4-Isopropyl-phenyl)-N-[2-(4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide; N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide;

N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-ethyl-1H-indazol-5-yl)-acetamide;

N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indazol-5-yl)-acetamide;

2-(3-Cyclopropyl-1H-indazol-5-yl)-N-[2-(3,4-difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

2-(1-Butyl-1H-indazol-5-yl)-N-[2-(3,4-difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(2-methyl-1H-indol-5-yl)-acetamide;

2-(3-Butyl-1H-indazol-5-yl)-N-[2-(3,4-difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-isopropyl-1H-indazol-5-yl)-acetamide;

N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-propyl-1H-indazol-5-yl)-acetamide;

2-(3-Cyclopropyl-1-methyl-1H-indazol-5-yl)-N-[2-(3,4-difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-acetamide;

N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(3-trifluoromethyl-1H-indazol-5-yl)-acetamide;

N-[2-(4-Ethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indol-5-yl)-acetamide;

2-[6-(3,3-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-N-[2-(4-ethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(4-Ethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methyl-oxetan-3-yl)-phenyl]-acetamide;

2-(4-tert-Butyl-phenyl)-N-[2-(4-ethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide; N-[2-(4-Ethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide;

N-[2-(4-Ethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;

N-[2-(4-Ethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;

2-(6-Diethylamino-pyridin-3-yl)-N-[2-(3,4-dimethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

2-[6-(3,3-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-N-[2-(3,4-dimethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

2-(4-tert-Butyl-phenyl)-N-[2-(3,4-dimethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(3,4-Dimethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide; N-[2-(3,4-Dimethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;

N-[2-(4-Fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indol-5-yl)-acetamide;

N-[2-(4-Fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methyl-oxetan-3-yl)-phenyl]-acetamide;

2-(4-tert-Butyl-phenyl)-N-[2-(4-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(4-Fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;

N-[2-(4-Fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;

N-[2-(4-Methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indol-5-yl)-acetamide;

2-(6-Diethylamino-pyridin-3-yl)-N-[2-(4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide; 2-[6-(3,3-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-N-[2-(4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(4-Methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methyl-oxetan-3-yl)-phenyl]-acetamide;

2-(4-tert-Butyl-phenyl)-N-[2-(4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(4-Methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyri din-3-yl)-acetamide;

N-[2-(4-Methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;

N-[2-(4-Methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indol-5-yl)-acetamide;

2-[6-(3,3-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-N-[2-(4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

2-(4-tert-Butyl-phenyl)-N-[2-(4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(4-Methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methyl-oxetan-3-yl)-phenyl]-acetamide;

N-[2-(4-Methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;

N-[2-(4-Methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;

N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indol-5-yl)-acetamide;

N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[6-(3,3-difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-acetamide;

N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methyl-oxetan-3-yl)-phenyl]-acetamide;

2-(4-tert-Butyl-phenyl)-N-[2-(4-cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide; N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;

N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;

N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indol-5-yl)-acetamide;

N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methyl-oxetan-3-yl)-phenyl]-acetamide;

2-(4-tert-Butyl-phenyl)-N-[2-(3,5-difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide;

N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;

N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;

2-(4-tert-Butyl-phenyl)-N-{2-[4-(2-methoxy-ethoxy)-benzyl]-2H-[1,2,3]triazol-4-yl}-acetamide;

N-{2-[4-(2-Methoxy-ethoxy)-benzyl]-2H-[1,2,3]triazol-4-yl}-2-(1-methyl-1H-indol-5-yl)-acetamide;

2-(4-tert-Butyl-phenyl)-N-[2-(4-difluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide; N-[2-(4-Difluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indol-5-yl)-acetamide;

2-(4-tert-Butyl-phenyl)-N-[2-(4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide; 2-(1-Methyl-1H-indol-5-yl)-N-[2-(4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

2-(1-Methyl-1H-indazol-5-yl)-N-[2-(4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

2-[4-(3-Methyl-oxetan-3-yl)-phenyl]-N-[2-(4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

2-[6-(3,3-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-N-[2-(4-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

2-(6-Diethylamino-pyridin-3-yl)-N-[2-(4-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide; 2-(4-tert-Butyl-phenyl)-N-[2-(4-cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[6-(3,3-difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-acetamide;

N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;

N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indol-5-yl)-acetamide;

N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indol-5-yl)-acetamide;

N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-6-yl)-acetamide;

N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indazol-5-yl)-acetamide;

N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-ethyl-1H-indazol-5-yl)-acetamide;

N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-propyl-1H-indazol-5-yl)-acetamide;

N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indol-6-yl)-acetamide;

N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indol-6-yl)-acetamide;

N-[2-(4-Fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(oxetan-3-ylmethoxy)-phenyl]-acetamide;

N-[2-(4-Fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-6-yl)-acetamide;

N-[2-(4-Fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methoxy-oxetan-3-yl)-phenyl]-acetamide;

2-[4-(3,3-Difluoro-cyclobutylmethoxy)-phenyl]-N-[2-(4-fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(4-Fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methyl-oxetan-3-ylmethoxy)-phenyl]-acetamide;

N-[2-(4-Fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;

2-[4-(3,3-Difluoro-cyclobutoxy)-phenyl]-N-[2-(4-fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

2-[6-(3,3-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-N-[2-(4-fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(4-Fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-yl)-phenyl]-acetamide;

2-(1-Ethyl-1H-indazol-5-yl)-N-[2-(4-fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

2-(1,3-Dimethyl-1H-indol-5-yl)-N-[2-(4-fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

2-(4-tert-Butyl-phenyl)-N-[2-(4-fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(3-Fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(oxetan-3-ylmethoxy)-phenyl]-acetamide;

N-[2-(3-Fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-6-yl)-acetamide;

N-[2-(3-Fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methoxy-oxetan-3-yl)-phenyl]-acetamide;

N-[2-(3-Fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methyl-oxetan-3-ylmethoxy)-phenyl]-acetamide;

N-[2-(3-Fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;

2-[4-(3,3-Difluoro-cyclobutoxy)-phenyl]-N-[2-(3-fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

2-[6-(3,3-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-N-[2-(3-fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(3-Fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-yl)-phenyl]-acetamide;

2-(1-Ethyl-H-indazol-5-yl)-N-[2-(3-fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

2-(1,3-Dimethyl-1H-indol-5-yl)-N-[2-(3-fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

2-(4-tert-Butyl-phenyl)-N-[2-(3-fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide; N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(oxetan-3-ylmethoxy)-phenyl]-acetamide;

N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-6-yl)-acetamide;

N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methoxy-oxetan-3-yl)-phenyl]-acetamide;

N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3,3-difluoro-cyclobutylmethoxy)-phenyl]-acetamide;

N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methyl-oxetan-3-ylmethoxy)-phenyl]-acetamide;

N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;

N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3,3-difluoro-cyclobutoxy)-phenyl]-acetamide;

N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-yl)-phenyl]-acetamide;

N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-ethyl-1H-indazol-5-yl)-acetamide

N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indol-5-yl)-acetamide;

N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(oxetan-3-ylmethoxy)-phenyl]-acetamide;

N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-6-yl)-acetamide;

N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methoxy-oxetan-3-yl)-phenyl]-acetamide;

N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methyl-oxetan-3-ylmethoxy)-phenyl]-acetamide;

N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;

2-[4-(3,3-Difluoro-cyclobutoxy)-phenyl]-N-[2-(3,5-difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[6-(3,3-difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-acetamide;

N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-yl)-phenyl]-acetamide;

N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-ethyl-1H-indazol-5-yl)-acetamide;

N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indol-5-yl)-acetamide;

N-[2-(4-Fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;

N-[2-(3-Fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;

N-[2-(4-Fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide; N-[2-(3-Fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide; N-[2-(4-Fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;

N-[2-(3-Fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;

2-[4-(Cyano-dimethyl-methyl)-phenyl]-N-[2-(4-cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

2-(4-tert-Butyl-phenyl)-N-[2-(4-cyano-3-fluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-trifluoromethyl-phenyl)-acetamide; N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(5-fluoro-6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;

2-(4-tert-Butyl-phenyl)-N-[2-(4-cyano-3-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-6-yl)-acetamide;

N-[2-(4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;

N-[2-(4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide; N-[2-(4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3,3-difluoro-cyclobutoxy)-phenyl]-acetamide;

N-[2-(4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[6-(3,3-difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-acetamide;

N-[2-(4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-ethyl-1H-indazol-5-yl)-acetamide;

N-[2-(4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indazol-5-yl)-acetamide;

N-[2-(4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;

N-[2-(4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indol-5-yl)-acetamide;

2-(4-tert-Butyl-phenyl)-N-[2-(3-cyano-4-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(3-Cyano-4-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;

N-[2-(3-Cyano-4-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide;

N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-ylmethoxy)-phenyl]-acetamide;

N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3,3-difluoro-1-methyl-cyclobutylmethoxy)-phenyl]-acetamide;

N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indazol-5-yl)-acetamide;

2-(4-tert-Butyl-phenyl)-N-[2-(4-difluoromethoxy-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(4-Difluoromethoxy-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;

N-[2-(4-Difluoromethoxy-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide;

N-[2-(4-Difluoromethoxy-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;

N-[2-(4-Difluoromethoxy-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[6-(3,3-difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-acetamide;

N-[2-(4-Difluoromethoxy-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;

2-(4-tert-Butyl-phenyl)-N-[2-(3-fluoro-4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(3-Fluoro-4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-6-yl)-acetamide;

N-[2-(3-Fluoro-4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;

N-[2-(3-Fluoro-4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide;

N-[2-(3-Fluoro-4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;

2-[6-(3,3-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-N-[2-(3-fluoro-4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

2-(1-Ethyl-1H-indazol-5-yl)-N-[2-(3-fluoro-4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

2-(1,3-Dimethyl-1H-indazol-5-yl)-N-[2-(3-fluoro-4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(3-Fluoro-4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;

N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methyl-oxetan-3-ylmethoxy)-phenyl]-acetamide;

N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-ylmethoxy)-phenyl]-acetamide;

N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;

N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3,3-difluoro-cyclobutoxy)-phenyl]-acetamide;

N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3,3-difluoro-1-methyl-cyclobutylmethoxy)-phenyl]-acetamide;

N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-yl)-phenyl]-acetamide;

N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[3-methyl-4-(2,2,2-trifluoro-ethoxy)-phenyl]-acetamide;

N-[2-(3-Cyano-4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-ylmethoxy)-phenyl]-acetamide;

N-[2-(3-Cyano-4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-yl)-phenyl]-acetamide;

2-(4-tert-Butyl-phenyl)-N-[2-(3-cyano-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(3-Cyano-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;

N-[2-(3-Cyano-4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;

N-[2-(3-Cyano-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide;

N-[2-(3-Cyano-4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methoxy-oxetan-3-yl)-phenyl]-acetamide;

N-[2-(3-Cyano-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[6-(3,3-difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-acetamide;

N-[2-(3-Cyano-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;

N-[2-(3-Cyano-4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3,3-difluoro-cyclobutoxy)-phenyl]-acetamide;

N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indazol-5-yl)-acetamide;

N-[2-(3-Cyano-4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[6-(3,3-difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-acetamide;

N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;

N-[2-(3-Cyano-4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;

N-[2-(3-Cyano-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-yl)-phenyl]-acetamide;

N-[2-(3-Cyano-4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-6-yl)-acetamide;

N-[2-(3-Cyano-4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide; 2-(4-tert-Butyl-phenyl)-N-[2-(3-cyano-4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

2-(4-tert-Butyl-phenyl)-N-[2-(3,4-difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[6-(3,3-difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-acetamide;

N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-ethyl-1H-indazol-5-yl)-acetamide;

N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;

N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide;

N-[2-(3-Cyano-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3,3-difluoro-cyclobutoxy)-phenyl]-acetamide;

N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-yl)-phenyl]-acetamide;

N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-6-yl)-acetamide;

N-[2-(3-Cyano-4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;

N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;

N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methoxy-oxetan-3-yl)-phenyl]-acetamide;

N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-ylmethoxy)-phenyl]-acetamide;

2-[4-(3,3-Difluoro-cyclobutoxy)-phenyl]-N-[2-(3,4-difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

2-[4-(1-Cyano-cyclopropyl)-phenyl]-N-[2-(4-cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-(2-(4-cyano-3-fluorobenzyl)-2H-1,2,3-triazol-4-yl)-2-(4-(pentafluorosulfanyl)phenyl)acetamide;

N-[2-(4-Cyano-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;

N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;

N-[2-(4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-yl)-phenyl]-acetamide;

N-[2-(3-Cyano-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;

N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methoxy-oxetan-3-yl)-phenyl]-acetamide;

N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3,3-difluoro-cyclobutylmethoxy)-phenyl]-acetamide;

2-(4-tert-Butyl-phenyl)-N-[2-(4-cyano-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;

N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indol-5-yl)-acetamide;

N-[2-(4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;

N-[2-(5-Cyano-pyridin-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-2-[3-methyl-4-(2,2,2-trifluoro-ethoxy)-phenyl]-acetamide;

N-[2-(5-Cyano-pyridin-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indol-5-yl)-acetamide;

2-(4-tert-Butyl-phenyl)-N-[2-(5-cyano-pyridin-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-acetamide; N-[2-(5-Cyano-pyridin-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;

N-[2-(5-Cyano-pyridin-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3,3-difluoro-cyclobutoxy)-phenyl]-acetamide;

N-[2-(5-Cyano-pyridin-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-2-(5-fluoro-6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;

N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-phenyl]-acetamide; and

N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-((1S*,2S*)-2-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;

or a salt of such a compound.

10. A pharmaceutical composition containing, as active principle, a compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, and at least one therapeutically inert excipient.

11. A compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, for use as a medicament.

12. A compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, for use in the treatment of epilepsy; sleep disorders; sleep disturbances; pain; neurological disorders; cardiovascular disorders; cancer; diabetes; diabetic neuropathy; infertility; and sexual dysfunction.

13. A method of treating a disease comprising administering a pharmaceutically active amount of the compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the disease is selected from epilepsy; sleep disorders; sleep disturbances; pain; neurological disorders; cardiovascular disorders; cancer; diabetes; diabetic neuropathy; infertility; and sexual dysfunction.