Composition comprising a compound from the family of avermectins and doxycycline for the treatment of rosacea
View Patent ↗The use of a composition comprising a compound from the family of avermectins, preferably ivermectin, and doxycycline or one of the salts thereof that is pharmaceutically acceptable in the treatment and/or slowing of the appearance of the symptoms of rosacea is described.
1. A method of improving or slowing progression of symptoms associated with rosacea exhibiting Demodex resistant to treatment with a compound of the avermectin family alone, the method comprising administering to an individual in need thereof an effective amount of a composition comprising the compound of the avermectin family with doxycycline or a pharmaceutically acceptable salt thereof.
2. The method according to claim 1 , wherein the compound of the avermectin family is ivermectin.
3. The method according to claim 1 , wherein the compound of the avermectin family represents 0.001% to 10% by weight of the total weight of the composition.
4. The method according to claim 3 , wherein the compound of the avermectin family represents 0.5% to 1% by weight of the total weight of the composition.
5. The method according to claim 1 , wherein the doxycycline or a pharmaceutically acceptable salt thereof represents 0.0001% to 5% by weight of the total weight of the composition.
6. The method according to claim 1 , wherein the composition is formulated for topical or oral administration.
7. The method according to claim 1 , wherein the compound of the avermectin family is administered at 100 μg to 5 g per day.
8. The method according to claim 1 , wherein the doxycycline or a pharmaceutically acceptable salt thereof is administered at 100 μg to 1 g per day.
9. The method according to claim 3 , wherein the compound of the avermectin family is present in an amount of 0.001% to 5% by weight of the total weight of the composition.
10. The method according to claim 3 , wherein the compound of the avermectin family is present in an amount of 0.1% to 2% by weight of the total weight of the composition.
11. The method according to claim 4 , wherein the compound of the avermectin family is present in an amount of 1% by weight of the total weight of the composition.
12. The method according to claim 5 , wherein the doxycycline or salt thereof is present in an amount from 0.0001% to 3% by weight of the total weight of the composition.
13. The method according to claim 7 , wherein the compound of the avermectin family is administered at 100 μg to 3 g per day.
14. The method according to claim 13 , wherein the compound of the avermectin family is administered at 100 μg to 1 g per day.
15. The method according to claim 14 , wherein the compound of the avermectin family is administered at 150 μg to 500 mg per day.
16. The method according to claim 15 , wherein the compound of the avermectin family is administered at 200 μg to 200 mg per day.
17. The method according to claim 8 , wherein the doxycycline or a pharmaceutically acceptable salt thereof is administered at 100 μg and 500 mg per day.
18. The method according to claim 17 , wherein the doxycycline or a pharmaceutically acceptable salt thereof is administered at 10 μg and 300 mg per day.
19. The method according to claim 18 , wherein the doxycycline or a pharmaceutically acceptable salt thereof is administered at 40 mg, 100 mg or 200 mg per day.