IP Library Granted Patent US 11,156,552
Granted Patent B2
US 11,156,552 · App. 15/514,223 · Granted Oct 26, 2021

Prism, prism production method, mold, and sensor chip

Inventors: Yoshihiro Okumura (Toyohashi, JP); Takehiko Goshima (Kunitachi, JP); Seiji Yuasa (Tama, JP)
Assignee: Konica Minolta, Inc.
G01N21/553B29C45/0025G01N21/41G01N21/64G01N21/6428G01N33/54373G02B5/04B29D11/0074G01N2021/6439
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Quick Facts
Patent No.
US 11,156,552
App. No.
15/514,223
Granted
Oct 26, 2021
Kind
B2
Abstract

A prism ( 1090 ) is configured from a dielectric medium and is used in analysis using surface plasmons. The prism ( 1090 ) is provided with an incidence surface ( 1170 ) on which excitation light from outside is incident, a reflection surface ( 1172 ) on which excitation light having entered the incidence surface ( 1170 ) is reflected, an emission surface ( 1174 ) from which excitation light reflected by the reflection surface ( 1172 ) is emitted, and an opposing surface ( 1175 ) opposing the reflection surface ( 1172 ). A gold film ( 1092 ) is formed on the reflection surface ( 1172 ). The opposing surface ( 1175 ) has a sink-mark surface ( 1200 ), and the sink-mark surface ( 1200 ) is a transparent surface.

Claims (42)

1. A prism which is constituted by a dielectric medium and is used for an analysis utilizing surface plasmon, comprising:

an incidence surface through which excitation light enters from an outside;

a reflection surface on which the excitation light which has entered through the incidence surface is reflected;

an emission surface through which the excitation light which has been reflected on the reflection surface exits; and

an opposing surface which is opposed to the reflection surface,

wherein a metal film is formed on the reflection surface,

wherein the opposing surface comprises a sink-mark surface,

wherein the sink-mark surface is transparent,

wherein a surface roughness Ra of the sink-mark surface is from 0.1 nm to less than 0.5 μm, and

wherein the sink-mark surface comprises a curved surface which forms a convexity towards the reflection surface.

2. The prism according to claim 1 ,

wherein the sink-mark surface is disposed vertically right below an area including an antigen trapping position of the metal film.

3. A method for producing the prism according to claim 1 , comprising:

preparing a mold with a certain cavity;

injecting a certain resin to fill the cavity;

applying a dwell pressure to the resin; and

cooling the resin,

wherein the mold comprises a transfer area for forming the sink-mark surface, and

wherein a surface roughness Ra of the transfer area is from 0.1 nm to less than 0.5 μm.

4. A method for producing the prism according to claim 1 , comprising:

preparing a mold with a certain cavity;

injecting a certain resin to fill the cavity;

applying a dwell pressure to the resin; and

cooling the resin,

wherein the opposing surface of the mold comprises a first transfer area for forming the sink-mark surface and a second transfer area for forming a non-sink-mark surface between the sink-mark surface and the incidence surface or the emission surface,

wherein a surface roughness Ra of the first transfer area is from 0.1 nm to less than 0.5 μm, and

wherein a surface roughness Ra of the second transfer area is from 0.5 μm to less than 100 μm.

5. A mold for producing the prism according to claim 1 , comprising:

a transfer area for forming the sink-mark surface,

wherein a surface roughness Ra of the transfer area is from 0.1 nm to less than 0.5 μm.

6. A mold for producing the prism according to claim 1 , comprising:

a first transfer area for forming the sink-mark surface of the opposing surface and a second transfer area for forming a non-sink-mark surface of the opposing surface between the sink-mark surface and the incidence surface or the emission surface,

wherein a surface roughness Ra of the first transfer area is from 0.1 nm to less than 0.5 μm, and

wherein a surface roughness Ra of the second transfer area is from 0.5 μm to less than 100 μm.

7. A sensor chip, comprising:

the prism according to claim 1 ; and

a channel forming body in which a channel is formed.

8. The prism according to claim 1 , wherein the metal film is made of Gold.

9. The prism according to claim 8 , wherein the Gold film has a film thickness of from 40 nm to 50 nm.

10. The prism according to claim 9 , wherein the prism is made of a resin material comprising a cycloolefin polymer.

11. The prism according to claim 10 , wherein water absorption of the prism is equal to or less than 0.2%.

12. The prism according to claim 11 , wherein the resin material of the prism has a photoelastic coefficient equal to or less than 80×10 −12 Pa −1 .

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 21, 2022
From: KONICA MINOLTA, INC.
To: OTSUKA PHARMACEUTICAL CO., LTD.
Reel/Frame 059747/0589 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 24, 2017
From: OKUMURA, YOSHIHIRO; GOSHIMA, TAKEHIKO; YUASA, SEIJI
To: KONICA MINOLTA, INC.
Reel/Frame 041729/0899 →
Priority Claims (1)
JP JP2014-194253 · Sep 24, 2014 · national
Continuity (1)
Related Publication 20170276604A1 · Sep 28, 2017