IP Library › Granted Patent US 9,862,937
Granted Patent B2
US 9,862,937 · App. 15/515,303 · Granted Jan 9, 2018

Process for the preparation of halo-substituted trifluoroacetophenones

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Quick Facts
Patent No.
US 9,862,937
App. No.
15/515,303
Granted
Jan 9, 2018
Kind
B2
Abstract

The invention relates to a process for the preparation of a compound of formula I (I), wherein R 1 is hydrogen, fluoro or chloro; which process comprises a) reacting a compound of formula II (II), wherein R 1 is hydrogen, fluoro or chloro; with a nitration agent to the compound of formula (III), wherein R 1 is hydrogen, fluoro or chloro; and b) reacting the compound of formula III with chlorine gas at temperature from 180° C. to 250° C. to the compound of formula I.

Claims (9)

1. A process for the preparation of a compound of formula I

wherein R 1 is hydrogen, fluoro or chloro; which process comprises

a) reacting a compound of formula II

wherein R 1 is hydrogen, fluoro or chloro; with a nitration agent to the compound of formula

wherein R 1 is hydrogen, fluoro or chloro; and

b) reacting the compound of formula III with chlorine gas at temperature from 180° C. to 250° C. to form the compound of formula I.

2. A process according to claim 1 , characterised in that the nitration agent is selected from sulfuric acid, nitric acid and their salts.

3. The compound of formula III,

wherein R 1 is fluoro.

Assignments (2)
MERGER AND CHANGE OF NAME Recorded Mar 14, 2025
From: SYNGENTA PARTICIPATIONS AG; SYNGENTA PARTICIPATIONS AG
To: SYNGENTA CROP PROTECTION AG
Reel/Frame 070517/0838 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 25, 2017
From: GRIBKOV, DENIS
To: SYNGENTA PARTICIPATIONS AG
Reel/Frame 043946/0466 →