Treatment of retina and nerve using laminin
The present invention provides a technique for treating retinal epithelium and/or nerves. More specifically, the present invention is an agent for the treatment or prevention of retinal disease or the like and/or a disease, disorder, or ophthalmological state of the nerves, the agent including at least one factor selected from the group consisting of laminin and fragments thereof, wherein the problem is solved by also providing a technique characterized in that this agent is administered together with retinal pigment epithelial cells and/or nerve cells. Specifically, the present invention can include laminin 411 (α4β1γ1), laminin 511 (α5β1γ1), laminin 521 (α5β2γ1), or fragments of these.
1. A method for treating a disease, a disorder, or a condition of a nerve requiring cell transplantation in a subject, comprising administering (a) at least one agent selected from the group consisting of laminin 511 (α5β1γ1) and fragments thereof and (b) a nerve cell or a retinal pigment epithelial cell to the subject, wherein the disease, the disorder, or the condition of the nerve requiring cell transplantation in the subject includes retinitis pigmentosa, macular degeneration, Stargardt disease, glaucoma, or optic neuropathy.
2. The method of claim 1 , wherein the nerve cell is administered to the subject.
3. The method of claim 1 , wherein the agent is laminin 511-E8 fragment.