PALATABLE CHEWABLE VETERINARY COMPOSITION
The present invention is directed to a palatable soft chew veterinary composition comprising at least one active agent, at least one binding agent, at least one disintegrant, at least one wetting agent, and at least one flavorant, and methods for controlling or treating a condition in an animal comprising administering the composition to said animal in need thereof.
1 . A palatable soft chew veterinary composition comprising:
1. a therapeutically effective amount of at least one active agent;
2. at least one binding agent;
3. at least one disintegrant,
4. at least one wetting agent, and
5. at least one flavorant.
2 . The composition of claim 1 , wherein the binding agent is selected from the group consisting of microcrystalline cellulose, hydroxypropyl cellulose, polyvinylpyrrolidone, and mixtures thereof and wherein the binding agent makes up about 10 to about 25 w/w % of the composition.
3 . The composition of claim 1 , wherein the wetting agent is selected from the group consisting of glycerin, glycerol formal, ethylene glycol, propylene glycol, butyl diglycol, castor oil, cottonseed oil, sesame oil, safflower oil, soybean oil, corn oil, glyceryl stearates, isopropyl myristate, ethyl oleate, and propylene glycol monolaurate, and mixtures thereof, and wherein the wetting agent makes up about 20 to about 35 w/w % of the composition.
4 . The composition of claim 3 wherein said disintegrant is croscarmellose sodium and makes up about 3 to about 15 w/w % of the composition.
5 . The composition of claim 4 wherein said flavorant is an animal based natural flavorant, artificial flavorant, or mixture thereof and wherein the composition further comprises an antioxidant.
6 . The composition of claim 1 wherein the active agent is selected from carprofen, oclacitinib maleate, afoxolaner, fluralaner, sarolaner, lotilaner, clavulanic acid and amoxicillin, cefpodoxime proxetil, and doxycycline hyclate.
7 . The composition of claim 6 wherein the active agent is selected from afoxolaner, fluralaner, sarolaner, and lotilaner, and wherein said composition further comprises at least one additional antiparasitic agent.
8 . The composition of claim 7 wherein the at least one additional antiparasitic agent is selected from the group consisting of a macrocyclic lactone, pyrantel, praziquantel, levamisole, triclabendazole, and mixtures thereof.
9 . A method of treating an animal for a parasitic infection, pain and inflammation, pruritis and atopic dermatitis, or emesis by orally administering a palatable soft chew composition comprising
a. a therapeutically effective amount of at least one active agent;
b. at least one binding agent;
c. at least one disintegrant,
d. at least one wetting agent, and
e. at least one flavorant; and optionally
f. at least one additional antiparasitic agent.
10 . The method of claim 9 for treating an animal for pain and inflammation by orally administering a palatable soft chew composition comprising
a. a therapeutically effective amount of at least one active agent, wherein said agent is carprofen;
b. at least one binding agent;
c. at least one disintegrant,
d. at least one wetting agent, and
e. at least one flavorant.
11 . The method of claim 9 for treating an animal for pruritis and atopic dermatitis infection by orally administering a palatable soft chew composition comprising
a. a therapeutically effective amount of at least one active agent, wherein said agent is apoquel;
b. at least one binding agent;
c. at least one disintegrant,
d. at least one wetting agent, and
e. at least one flavorant.
12 . The method of claim 9 for treating an animal for emesis by orally administering a palatable soft chew composition comprising
a. a therapeutically effective amount of at least one active agent, wherein said agent is maropitant;
b. at least one binding agent;
c. at least one disintegrant,
d. at least one wetting agent, and
e. at least one flavorant.
13 . The method of claim 9 wherein the animal is a companion animal.
14 . The method of claim 13 wherein the companion animal is a dog.
15 . A process for preparing a palatable soft chew veterinary composition of claim 1 , comprising:
1. sieving and blending all dry ingredients;
2. loading the blended dry ingredients into an extruder hopper;
3. wetting the blended ingredients in the extruder at a temperature range of about 20-30° C.;
4. drying and cutting the extrudate.
16 . The composition of claim 6 wherein the active agent is carprofen.
17 . The composition of claim 6 wherein the active agent is oclacitinib maleate.
18 . The composition of claim 6 wherein the active agent is clavulanic acid and amoxicillin.
19 . The method of claim 9 for treating an animal for a parasitic infection by orally administering a palatable soft chew composition comprising
a. a therapeutically effective amount of at least one active agent selected from afoxolaner, fluralaner, lotilaner, and sarolaner;
b. at least one binding agent;
c. at least one disintegrant,
d. at least one wetting agent, and
e. at least one flavorant; and optionally
f. at least one additional antiparasitic agent.
20 . The method of claim 19 wherein the active agent is sarolaner.