IP Library Granted Patent US 10,213,413
Granted Patent B2
US 10,213,413 · App. 15/523,995 · Granted Feb 26, 2019

Antiviral agents directed against respiratory syncytial virus

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Quick Facts
Patent No.
US 10,213,413
App. No.
15/523,995
Granted
Feb 26, 2019
Kind
B2
Abstract

The present invention relates to N1-benzyl substituted pyrazoles as antiviral agents directed against respiratory syncytial virus.

Claims (12)

1. A method for treating an infection by respiratory syncytial virus (RSV), comprising administering to a subject an agent, wherein said agent is represented in formula (I):

wherein :

R1 and R2 are identical or different and are independently chosen among hydrogen, hydroxyl, halogen, haloalkyl, alkyl, aryl, arylalkyl, nitro, cyano, amino, alkoxy, alkoxyalkyl, heteroaryl, cycloalkyl and heterocyclyl; and

R3 and R4 are identical or different and are independently chosen among carboxylate, ester, substituted or non-substituted alkyloxycarbonyl, halogen, haloalkyl, alkyl, aryl, arylalkyl, nitro, cyano, amino, alkoxy, alkoxyalkyl, heteroaryl, cycloalkyl, heterocyclyl, boronate, phosphate, phosphonate, sulfinyl, sulfonyl, sulfonate, and sulfonamino, sulfonamido.

2. The method according to claim 1 , wherein R3 and R4 are identical and are both carboxylate.

3. The method according to claim 1 , wherein R1 and R2 are identical or different and are independently a halogen independently selected from the group consisting of: fluorine (F), chlorine (Cl), bromine (Br), and iodine (I).

4. The method according to claim 1 , wherein R1 and R2 are identical and are both hydrogen.

5. The method according to claim 1 , wherein R1 is fluorine and R2 is hydrogen.

6. The method according to claim 1 , wherein R1 is bromine and R2 is hydrogen.

7. The method according to claim 1 , wherein R1 is hydrogen and R2 is chlorine.

8. The method according to claim 1 , wherein R1 and R2 are identical and are both chlorine.

9. The method according to claim 1 , further comprising administering an antiviral agent with the agent of formula (I) as a combined preparation for simultaneous, separate or sequential, wherein said antiviral agent is selected from the group consisting of acyclovir, cidofovir, docosanol, famciclovir, foscarnet, fomivirsen, ganciclovir, idoxuridine, penciclovir, peramivir, trifluridine, valacyclovir, vidarabine, lamivudine, and ribavirin.

Assignments (4)
MERGER Recorded Aug 22, 2022
From: UNIVERSITE DE PARIS 11 - PARIS SUD (ALSO NAMED UNIVERSITÉ PARIS-SUD)
To: UNIVERSITE PARIS-SACLAY
Reel/Frame 060856/0245 →
CORRECTIVE ASSIGNMENT TO CORRECT THE RECEIVING PARTY DATA PREVIOUSLY RECORDED ON REEL 052469 FRAME 0167. ASSIGNOR(S) HEREBY CONFIRMS THE CHANGE OF NAME. Recorded Apr 28, 2020
From: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)
To: INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
Reel/Frame 052510/0160 →
CHANGE OF NAME Recorded Apr 22, 2020
From: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)
To: INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT (INRAE)
Reel/Frame 052469/0167 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 9, 2017
From: SIZUN, CHRISTINA; DUQUERROY, STÉPHANE; ELEOUET, JEAN-FRANÇOIS; REY, FELIX; SCHWOK, ANNY SLAMA; DESMAELE, DIDIER; COUVREUR, PATRICK; TARUS, BOGDAN
To: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS; INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE; INSTITUT PASTEUR; UNIVERSITÉ PARIS-SUD
Reel/Frame 043241/0620 →