N-methyl-N-(1-phenyl-2-(1-pyrrolidinyl)ethyl)-2-aminophenylacetamide derivatives agonists for the kappa opioid receptor
View Patent ↗Compounds and pharmaceutically acceptable salts and solvates thereof are described. The compounds relate to and/or have application(s) in (among others) the fields of drug discovery, pharmacotherapy, physiology and organic chemistry.
1. A compound having a structure encompassed by the following formula:
wherein R 1 is selected from the group consisting of:
—N(CH 3 )CH 2 CH 2 OCH 3 ; —CH 2 CH(CH 3 )OH; —N(CH 2 CH 2 OCH 3 ) 2 , and
or pharmaceutically acceptable salts and solvates of each of the foregoing.
2. A compound having a structure encompassed by the following formula:
wherein R 2 is selected from the group consisting of: —CH 2 OCH 2 CF 3 ; and —CH(CH 3 )OH,
or pharmaceutically acceptable salts and solvates of each of the foregoing.
3. A compound having a structure encompassed by the following formula:
wherein R 3 is selected from the group consisting of:
or pharmaceutically acceptable salts and solvates of each of the foregoing.
4. A compound having a structure encompassed by the following formula:
wherein:
G is selected from the group consisting of —C(O)— and —S(O) 2 —;
(a) is selected from 0, 1, 2, 3 and 4;
R 4 is selected from the group consisting of:
and
J is —H or —CF 3 ,
or pharmaceutically acceptable salts and solvates of each of the foregoing, with the proviso that the compound is not
5. A compound having a structure encompassed by the following formula:
wherein:
(b) is either 0 or 1; and
R 5 is selected from the group consisting of:
—NHCH 2 CH 2 CH 2 OCH 2 CH 2 OCH 2 CH 2 OCF 3 ; —NHC(CH 3 ) 3 ; —NHCH 3 ; and —N(CH 3 ) 2 ;
or pharmaceutically acceptable salts and solvates of each of the foregoing.
6. A compound selected from the group consisting of:
or pharmaceutically acceptable salts and solvates of each of the foregoing.
7. A pharmaceutical composition comprising a compound of claim 1 and at least one pharmaceutically acceptable excipient.
8. A composition of matter comprising a compound of claim 1 , wherein the compound is present in a dosage form.
9. A method for treating pain comprising administering a compound of claim 1 to a patient in need thereof.
10. A pharmaceutical composition comprising a compound of claim 2 and at least one pharmaceutically acceptable excipient.
11. A method for treating pain comprising administering a compound of claim 2 to a patient in need thereof.
12. A pharmaceutical composition comprising a compound of claim 3 and at least one pharmaceutically acceptable excipient.
13. A method for treating pain comprising administering a compound of claim 3 to a patient in need thereof.
14. A pharmaceutical composition comprising a compound of claim 4 and at least one pharmaceutically acceptable excipient.
15. A method for treating pain comprising administering a compound of claim 4 to a patient in need thereof.
16. A pharmaceutical composition comprising a compound of claim 5 and at least one pharmaceutically acceptable excipient.
17. A method for treating pain comprising administering a compound of claim 5 to a patient in need thereof.
18. A pharmaceutical composition comprising a compound of claim 6 and at least one pharmaceutically acceptable excipient.
19. A method for treating pain comprising administering a compound of claim 6 to a patient in need thereof.