Picolinamide compounds with fungicidal activity
This disclosure relates to picolinamides of Formula I and their use as fungicides.
1. A compound of Formula I
wherein
X is hydrogen;
Y is Q;
Q is
R 1 and R 11 are independently chosen from hydrogen or alkyl, optionally substituted with 0, 1 or multiple R 8 ; alternatively, R 1 and R 11 may be taken together to form a 3-6 membered saturated or partially saturated carbocycle or heterocycle, optionally substituted with 0, 1 or multiple R 8 ;
R 2 and R 12 are independently chosen from hydrogen, alkyl, aryl, or alkenyl, each optionally substituted with 0, 1 or multiple R 8 ;
R 3 is chosen from hydrogen, C 2 -C 6 alkyl, aryl, or alkenyl, each optionally substituted with 0, 1 or multiple R 8 ;
R 4 is chosen from alkyl, aryl, or acyl, each optionally substituted with 0, 1 or multiple R 8 ;
R 6 is chosen from hydrogen, alkoxy, or halo, each optionally substituted with 0, 1, or multiple R 8 ;
R 7 is chosen from hydrogen, —C(O)R 9 , or —CH 2 OC(O)R 9 ;
R 8 is chosen from hydrogen, alkyl, aryl, acyl, halo, alkenyl, alkoxy, or heterocyclyl, each optionally substituted with 0, 1, or multiple R 10 ;
R 9 is chosen from alkyl, alkoxy, or aryl, each optionally substituted with 0, 1, or multiple R 8 ; and
R 10 is chosen from hydrogen, alkyl, aryl, acyl, halo, alkenyl, alkoxy, or heterocyclyl.
2. The compound according to claim 1 , wherein R 6 is alkoxy.
3. The compound according to claim 2 , wherein R 7 is hydrogen.
4. The compound according to claim 2 , wherein R 1 and R 11 are independently chosen from hydrogen or alkyl.
5. The compound according to claim 4 , wherein R 2 and R 12 are independently chosen from hydrogen or alkyl.
6. The compound according to claim 1 , wherein R 3 is chosen from C 2 -C 6 alkyl, aryl, or alkenyl, each optionally substituted with 0, 1 or multiple R 8 .
7. The compound according to claim 6 , wherein R 4 is chosen from alkyl or aryl, each optionally substituted with 0, 1 or multiple R 8 .
8. The compound according to claim 1 , wherein R 1 and R 11 are independently chosen from hydrogen or alkyl, R 2 and R 12 are independently chosen from hydrogen or alkyl, R 3 is chosen from C 2 -C 6 alkyl, aryl, or alkenyl, each optionally substituted with 0, 1 or multiple R 8 , and R 4 is chosen from alkyl or aryl, each optionally substituted with 0, 1 or multiple R 8 .
9. The compound according to claim 8 , wherein R 7 is —C(O)R 9 .
10. The compound according to claim 9 , wherein R 9 is alkyl, optionally substituted with 0, 1 or multiple R 8 .
11. The compound according to claim 1 , wherein R 1 and R 11 are independently chosen from hydrogen or alkyl, R 2 and R 12 are independently chosen from hydrogen or alkyl, R 3 is C 2 -C 6 alkyl, optionally substituted with 0, 1 or multiple R 8 , and R 4 is chosen from alkyl or aryl, each optionally substituted with 0, 1 or multiple R 8 .
12. The compound according to claim 11 , wherein R 9 is chosen from —CH 3 , —CH 2 OCH 2 CH 3 , —CH 2 CH 2 OCH 3 , —CH(CH 3 ) 2 , —CH 2 CH 2 CH 2 CH 3 , or -cyclopropyl.