Picolinamides with fungicidal activity
View Patent ↗The invention relates to picolinamides of Formula I and their use as fungicides.
1. A compound of Formula I
wherein
X is hydrogen or C(O)R 5 ;
Y is hydrogen, C(O)R 5 , or Q;
Q is
R 1 is CH 2 OCH 3 , or hydrogen or alkyl, where alkyl is optionally substituted with 0, 1 or multiple R 8 ;
R 2 is methyl;
R 3 is chosen from C(O)OCH 3 or alkyl, alkenyl, or aryl, each optionally substituted with 0, 1 or multiple R 8 ;
R 4 is chosen from alkyl or aryl, each optionally substituted with 0, 1 or multiple R 8 ;
R 5 is alkoxy, optionally substituted with 0, 1, or multiple R 8 ;
R 6 is chosen from hydrogen or alkoxy, where alkoxy is optionally substituted with 0, 1, or multiple R 8 ;
R 7 is chosen from hydrogen, C(O)R 9 , or CH 2 OC(O)R 9 ;
R 8 is chosen from hydrogen, alkyl, aryl, halo, alkenyl, or phenoxy, each optionally substituted with 0, 1, or multiple R 10 ,
R 9 is chosen from alkyl, alkoxy, or aryl, each optionally substituted with 0, 1, or multiple R 8 ;
R 10 is chosen from alkyl, aryl, halo, haloalkyl, haloaryl, alkenyl, or alkoxy; and
R 11 is chosen from hydrogen or methyl.
2. A compound according to claim 1 , wherein X and Y are hydrogen.
3. A compound according to claim 2 , wherein R 1 and R 11 are independently chosen from hydrogen or methyl.
4. A compound according to claim 2 , wherein R 3 is independently chosen from alkyl or aryl, each optionally substituted with 0, 1 or multiple R 8 .
5. A compound according to claim 2 , wherein R 1 and R 11 are independently chosen from hydrogen or methyl, and R 3 is independently chosen from alkyl or aryl, each optionally substituted with 0, 1 or multiple R 8 .
6. A compound according to claim 1 , wherein X is C(O)R 5 and Y is hydrogen.
7. A compound according to claim 6 , wherein R 1 and R 11 are independently chosen from hydrogen or methyl.
8. A compound according to claim 6 , wherein R 3 is independently chosen from alkyl or aryl, each optionally substituted with 0, 1 or multiple R 8 .
9. A compound according to claim 6 , wherein R 1 and R 11 are independently chosen from hydrogen or methyl, and R 3 is independently chosen from alkyl or aryl, each optionally substituted with 0, 1 or multiple R 8 .
10. A compound according to claim 1 , wherein X is hydrogen and Y is Q.
11. A compound according to claim 10 , wherein R 7 is hydrogen.
12. A compound according to claim 11 , wherein R 6 is OCH 3 .
13. A compound according to claim 12 , wherein R 1 and R 11 are independently chosen from hydrogen or methyl.
14. A compound according to claim 12 , wherein R 3 is independently chosen from alkyl or aryl, each optionally substituted with 0, 1 or multiple R 8 .
15. A compound according to claim 12 , wherein R 1 and R 11 are independently chosen from hydrogen or methyl, and R 3 is independently chosen from alkyl or aryl, each optionally substituted with 0, 1 or multiple R 8 .
16. A compound according to claim 10 , wherein R 7 is C(O)R 9 , or CH 2 OC(O)R 9 .
17. A compound according to claim 16 , wherein R 1 and R 11 are independently chosen from hydrogen or methyl.
18. A compound according to claim 16 , wherein R 3 is independently chosen from alkyl or aryl, each optionally substituted with 0, 1 or multiple R 8 .
19. A compound according to claim 16 , wherein R 1 and R 11 are independently chosen from hydrogen or methyl, and R 3 is independently chosen from alkyl or aryl, each optionally substituted with 0, 1 or multiple R 8 .