Vaccine for use against subclinical
The present invention pertains to a vaccine comprising non live Lawsonia intracellularis antigen and a pharmaceutically acceptable carrier for use in a method to reduce in a pig the shedding of Lawsonia intracellularis bacteria associated with subclinical infection with Lawsonia intracellularis , by systemic administration of the vaccine to the pig.
1. A method to reduce the shedding of Lawsonia intracellularis bacteria associated with subclinical infection with Lawsonia intracellularis in a pig, by systemic administration of a vaccine comprising non live Lawsonia intracellularis antigen and a pharmaceutically acceptable carrier to the pig.
2. The method of claim 1 , wherein the method is for preventing shedding of the bacteria.
3. The method of claim 1 , wherein the method is also for reducing the negative impact on average daily weight gain (ADWG) of the pig associated with the subclinical infection with Lawsonia intracellularis .
4. The method of claim 1 , wherein the vaccine is administered only once.
5. The method of claim 1 , wherein the vaccine is administered when the pig is 3-10 days of age.
6. The method of claim 1 , wherein the non live Lawsonia intracellularis antigen comprises the carbohydrates that in live Lawsonia intracellularis bacteria are in association with the outer cell membrane of these bacteria.
7. The method of claim 1 , wherein the non live Lawsonia intracellularis antigen is antigen purified from a composition comprising killed Lawsonia intracellularis bacteria.
8. The method of claim 1 , wherein the non live Lawsonia intracellularis antigen is killed whole cell Lawsonia intracellularis .