Instrument for performing a diagnostic test on a fluidic cartridge

1. A cartridge reader for carrying out a diagnostic test on a sample contained in a fluidic cartridge inserted into the reader, comprising:

a housing;

an upper clamp occupying a fixed position relative to the reader and a lower clamp movable relative to the upper clamp, wherein the upper clamp and the lower clamp define a cartridge receiving region therebetween, wherein the cartridge receiving region comprises a tray configured to move between an open position and a closed position and to receive a cartridge;

a thermal module comprised in the lower clamp;

a pneumatics module comprising a plurality of pneumatic interface;

at least one mechanical actuator;

at least one blister actuator;

an electrical module comprising a plurality of pins; and

a barcode reader, wherein at least part of each of the pneumatics module, the at least one mechanical actuator, the at least one blister actuator, the electrical module and the barcode reader are coupled to the upper clamp so as to be spaced apart from the thermal module by the cartridge receiving region.

2. The cartridge reader of claim 1 , further comprising a control unit for controlling operation of the thermal module, the pneumatics module, the at least one mechanical actuator, the at least one blister actuator, the electrical module and the barcode reader.

3. The cartridge reader of claim 2 , wherein the housing comprises:

a first partition between a first thermal zone comprising the thermal module and a second thermal zone comprising the pneumatics module, the at least one mechanical actuator, the at least one blister actuator, the electrical module and the barcode reader; and

a second partition between the second thermal zone and a third thermal zone comprising the control unit.

4. The cartridge reader of claim 3 , wherein the first and second partitions comprise thermally insulating partition walls comprised in the housing.

5. The cartridge reader of claim 4 , wherein each of the first, second and third thermal zones comprises a fan configured to draw air in through a respective inlet in the housing, and further comprises one or more vents for allowing air to exit the housing.

6. The cartridge reader claim 3 , wherein the housing comprises a base, a front side, a rear side and a top; and wherein the first thermal zone is located at the base of the housing toward the front side; and wherein the third thermal zone is elevated above the base of the housing toward the rear side.

7. The cartridge reader of claim 6 , wherein the third thermal zone is spaced apart from the top of the housing.

8. The cartridge reader of claim 6 , wherein each of the first, second and third thermal zones comprises a fan configured to draw air through a respective inlet in the housing, and further comprises one or more vents for allowing air to exit the housing, and wherein the inlet for the fan of the first thermal zone is located in the base of the housing.

9. The cartridge reader of claim 6 , wherein each of the first, second and third thermal zones comprises a fan configured to draw air through a respective inlet in the housing, and further comprises one or more vents for allowing air to exit the housing, and wherein the inlet for the fan of the second thermal zone is located in the base of the housing.

10. The cartridge reader of claim 6 , wherein the one or more vents are located at the top of the housing, at the base of the housing and at the rear side of the housing.

11. The cartridge reader of claim 10 , wherein the vents at the bottom of the housing are connected with the first thermal zone.

12. The cartridge reader of claim 10 , wherein the vents at the top of the housing are connected with the second thermal zone.

13. The cartridge reader of claim 10 , wherein the vents at the rear side of the housing are connected with the second and third thermal zones.

14. The cartridge reader of claim 1 , wherein the tray comprises a rib, and the housing comprises a slot in which the rib may slide freely during movement of the tray from the open position to the closed position, and wherein the slot has a tapered portion sized to hold the rib firmly when the tray is in the closed position so as to prevent movement of the tray.

15. The cartridge reader of claim 1 , wherein the lower clamp is configured, in use, to lift a cartridge from the tray and fixedly hold the cartridge against the upper clamp.

16. The cartridge reader of claim 1 , wherein the upper clamp, the lower clamp and the tray are inclined at an angle of between 1° and 10° to a surface on which the housing is configured to rest.

17. The cartridge reader of claim 1 , further comprising a sensor for sensing when the tray is not in the closed position, a power supply, and a power supply controller configured to cut power to the thermal module when the sensor senses the tray is not in the closed position.

18. The cartridge reader of claim 1 , wherein the housing has an access panel configured to provide a user access to replace the thermal module.

19. The cartridge reader of claim 1 , further comprising alignment pins between the upper and lower clamps such that the lower clamp remains aligned with the upper clamp during movement relative thereto.

20. The cartridge reader of claim 1 , wherein the pneumatics module, the at least one mechanical actuator, the at least one blister actuator, and the electrical module are mounted in the housing using one or more springs.