IP Library Granted Patent US 11,351,104
Granted Patent B2
US 11,351,104 · App. 15/548,916 · Granted Jun 7, 2022

Colloidal dispersions of poly alpha-1,3-glucan based polymers

Inventors: Ji Yeon Huh (Newark, DE); Natnael Behabtu (Wilmington, DE); Rakesh Nambiar (West Chester, PA)
Assignee: NUTRITION & BIOSCIENCES USA 4, INC.
A61K8/73A23L27/60A61K8/04A61Q5/12A61Q15/00A61Q19/00A61Q19/10C12P19/04C12P19/18A23V2002/00
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Quick Facts
Patent No.
US 11,351,104
App. No.
15/548,916
Granted
Jun 7, 2022
Kind
B2
Abstract

A colloidal dispersion is disclosed comprising poly alpha-1,3-glucan or poly alpha-1,3-1,6-glucan and a solvent. The colloidal dispersion has utility in various applications, including food, oil field, pharmaceutical, personal care and specialty industries.

Claims (37)

1. A process of preparing a colloidal dispersion, said process comprising:

(a) providing an aqueous reaction solution comprising sucrose and a glucosyltransferase that synthesizes poly alpha-1,3-glucan, wherein a slurry containing poly alpha-1,3-glucan is produced, and at least 90% of the glycosidic linkages of the poly alpha-1,3-glucan are alpha-1,3-glycosidic linkages;

(b) filtering the slurry to provide a wet cake of the poly alpha-1,3-glucan, wherein the poly alpha-1,3-glucan is not dried; and

(c) dispersing the wet cake to provide a colloidal dispersion comprising water and the poly alpha-1,3-glucan, wherein the poly alpha-1,3-glucan of the colloidal dispersion comprises particles with an average diameter of 5 nm to 200 nm.

2. The process of claim 1 , further comprising, between steps (b) and (c), washing the wet cake with water.

3. The process of claim 1 , wherein at least 95% of the glycosidic linkages of the poly alpha-1,3-glucan are alpha-1,3-glycosidic linkages.

4. The process of claim 3 , wherein at least 98% of the glycosidic linkages of the poly alpha-1,3-glucan are alpha-1,3-glycosidic linkages.

5. The process of claim 1 , wherein the wet cake contains 60 wt % to 80 wt % water.

6. The process of claim 1 , wherein the particles form aggregates with an average diameter of 10 nm to 200 μm.

7. The process of claim 1 , wherein the colloidal dispersion comprises 0.1 wt % to 15 wt % poly alpha-1,3-glucan.

8. The process of claim 1 , further comprising:

(d) preparing a personal care product, pharmaceutical product, food product, household product, or industrial product comprising the colloidal dispersion.

9. The process of claim 2 , further comprising:

(d) preparing a personal care product, pharmaceutical product, food product, household product, or industrial product comprising the colloidal dispersion.

10. The process of claim 3 , further comprising:

(d) preparing a personal care product, pharmaceutical product, food product, household product, or industrial product comprising the colloidal dispersion.

11. The process of claim 4 , further comprising:

(d) preparing a personal care product, pharmaceutical product, food product, household product, or industrial product comprising the colloidal dispersion.

12. The process of claim 1 , wherein the particles have an average diameter of 10 nm to 100 nm.

13. A process of preparing a colloidal dispersion, said process comprising:

(a) providing a wet cake of poly alpha-1,3-glucan that is not dried, wherein at least 90% of the glycosidic linkages of the poly alpha-1,3-glucan are alpha-1,3-glycosidic linkages, and wherein the poly alpha-1,3-glucan is a product of an aqueous reaction comprising sucrose and a glucosyltransferase that synthesizes poly alpha-1,3-glucan; and

(b) dispersing the wet cake to provide a colloidal dispersion comprising water and the poly alpha-1,3-glucan, wherein the poly alpha-1,3-glucan of the colloidal dispersion comprises particles with an average diameter of 5 nm to 200 nm.

14. The process of claim 13 , further comprising, between steps (a) and (b), washing the wet cake with water.

15. The process of claim 13 , wherein at least 95% of the glycosidic linkages of the poly alpha-1,3-glucan are alpha-1,3-glycosidic linkages.

16. The process of claim 15 , wherein at least 98% of the glycosidic linkages of the poly alpha-1,3-glucan are alpha-1,3-glycosidic linkages.

17. The process of claim 13 , wherein the wet cake contains 60 wt % to 80 wt % water.

18. The process of claim 13 , wherein the colloidal dispersion comprises 0.1 wt % to 15 wt % poly alpha-1,3-glucan.

19. The process of claim 13 , further comprising:

(c) preparing a personal care product, pharmaceutical product, food product, household product, or industrial product comprising the colloidal dispersion.

20. The process of claim 14 , further comprising:

(c) preparing a personal care product, pharmaceutical product, food product, household product, or industrial product comprising the colloidal dispersion.

21. The process of claim 13 , wherein the particles form aggregates with an average diameter of 10 nm to 200 μm.

22. The process of claim 15 , further comprising:

(c) preparing a personal care product, pharmaceutical product, food product, household product, or industrial product comprising the colloidal dispersion.

23. The process of claim 16 , further comprising:

(c) preparing a personal care product, pharmaceutical product, food product, household product, or industrial product comprising the colloidal dispersion.

24. The process of claim 13 , wherein the particles have an average diameter of 10 nm to 100 nm.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 28, 2020
From: DUPONT INDUSTRIAL BIOSCIENCES USA, LLC
To: NUTRITION & BIOSCIENCES USA 4, INC.
Reel/Frame 055028/0496 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ENTITY TYPE PREVIOUSLY RECORDED AT REEL: 049879 FRAME: 0043. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Sep 6, 2019
From: E. I. DU PONT DE NEMOURS AND COMPANY
To: DUPONT INDUSTRIAL BIOSCIENCES USA, LLC
Reel/Frame 050300/0408 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 26, 2019
From: E. I. DU PONT DE NEMOURS AND COMPANY
To: DUPONT INDUSTRIAL BIOSCIENCES USA, LLC
Reel/Frame 049879/0043 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 21, 2018
From: BEHABTU, NATNAEL; HUH, JI YEON; NAMBIAR, RAKESH
To: E I DU PONT DE NEMOURS AND COMPANY
Reel/Frame 045306/0116 →