Specific A-beta species-binding peptides for the therapy and/or diagnosis of Alzheimer's dementia
View Patent ↗The invention relates to peptides binding specifically to Abeta species for treating and/or diagnosing Alzheimer's disease.
1. A peptide binding specifically to amyloid beta species, containing at least one amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10 and SEQ ID NO: 11.
2. The peptide of claim 1 for use in medicine.
3. The peptide of claim 1 for treating Alzheimer's disease.
4. The peptide of claim 1 for diagnosing Alzheimer's disease.
5. The peptide of claim 1 substantially composed of D-amino acids.
6. The peptide of claim 1 for inhibiting the formation of Abeta fibrils.
7. The peptide of claim 1 for binding to aggregated amyloid beta species.
8. A KIT, including a peptide according to claim 1 .
9. A composition comprising a peptide according to claim 1 .
10. A probe for specifically identifying and quantitatively and/or qualitatively determining amyloid beta monomers, amyloid beta fibrils and/or amyloid beta oligomers, comprising the peptide according to claim 1 .