AQUEOUS SOLUTION OF AN ESTERIFIED CELLULOSE ETHER
An aqueous composition comprising an esterified cellulose ether being at least partially dissolved in an aqueous liquid, wherein the esterified cellulose ether comprises groups of the formula —C(O)—R—COOH, wherein R is a divalent hydrocarbon group is produced in a process which comprises the step of a) mixing the esterified cellulose ether with the aqueous liquid, and b) maintaining or adjusting the degree of neutralization of the groups —C(O)—R—COOH of the esterified cellulose ether at or to less than 0.45 and setting the temperature of the mixture of the esterified cellulose ether and the aqueous liquid to less than 10 C to at least partially dissolve the esterified cellulose ether in the aqueous liquid.
1 . A process for producing an aqueous composition comprising at least 1 weight percent of an esterified cellulose ether dissolved in an aqueous liquid, wherein the esterified cellulose ether comprises groups of the formula —C(O)—R—COOH, wherein R is a divalent hydrocarbon group and the process comprises the step of
a) mixing the esterified cellulose ether with the aqueous liquid, and
b) maintaining or adjusting the degree of neutralization of the groups —C(O)—R—COOH of the esterified cellulose ether at or to less than 0.45 and setting the temperature of the mixture of the esterified cellulose ether and the aqueous liquid to less than 10° C. to at least partially dissolve the esterified cellulose ether in the aqueous liquid to provide the aqueous composition comprising at least 1 weight percent esterified cellulose ether dissolved in the aqueous liquid.
2 . The process of claim 1 wherein the mixture of the esterified cellulose ether and the aqueous liquid is kept at a temperature of less than 10° C. for at least 1 hour.
3 . The process of claim 1 wherein the temperature of the mixture of the esterified cellulose ether and the aqueous liquid is set to less than 5° C.
4 . The process of claim 1 wherein after at least partial dissolution of the esterified cellulose ether in the aqueous liquid at a temperature of less than 10° C. the temperature of the aqueous composition is increased to not more than 25° C.
5 . The process of claim 1 wherein the esterified cellulose ether comprises groups of the formula —C(O)—CH 2 —CH 2 —COOH and additionally comprises aliphatic monovalent acyl groups.
6 . The process of claim 1 wherein the esterified cellulose ether is hydroxypropyl methylcellulose acetate succinate.
7 . The process of claim 1 wherein the total degree of ester substitution of the esterified cellulose ether is up to 1.0.
8 . The process of claim 1 wherein the aqueous composition comprises at least 2 wt.-% esterified cellulose ether dissolved in the aqueous liquid.
9 . A process for manufacturing capsule shells comprising the steps of
producing, according to the process of claim 1 , an aqueous composition comprising at least 1 weight percent of an esterified cellulose ether dissolved in an aqueous liquid, wherein the esterified cellulose ether comprises groups of the formula
—C(O)—R—COOH, wherein R is a divalent hydrocarbon group and
contacting dipping pins having a higher temperature than the aqueous composition with the aqueous composition or with the portion of the aqueous composition wherein esterified cellulose ether is dissolved.
10 . A process for coating dosage forms comprising the steps of
producing, according to the process of claim 1 , an aqueous composition comprising at least 1 weight percent of an esterified cellulose ether dissolved in an aqueous liquid, wherein the esterified cellulose ether comprises groups of the formula
—C(O)—R—COOH, wherein R is a divalent hydrocarbon group and
contacting dosage forms with the aqueous composition or with the portion of the aqueous composition wherein esterified cellulose ether is dissolved.
11 . A process for preparing a solid dispersion of an active ingredient in an esterified cellulose ether comprising the steps of
producing, according to the process of claim 1 , an aqueous composition comprising at least 1 weight percent of an esterified cellulose ether dissolved in an aqueous liquid, wherein the esterified cellulose ether comprises groups of the formula
—C(O)—R—COOH, wherein R is a divalent hydrocarbon group,
dissolving an active ingredient in the aqueous composition or in the portion of the aqueous composition wherein esterified cellulose ether is dissolved, and
drying the aqueous composition or the portion of the aqueous composition wherein esterified cellulose ether and active ingredient are dissolved to produce the solid dispersion of an active ingredient in an esterified cellulose ether.
12 . An aqueous composition comprising at least 1 weight percent of an esterified cellulose ether dissolved in an aqueous liquid, wherein
i) the esterified cellulose ether comprises groups of the formula
—C(O)—R—COOH having a degree of neutralization of less than 0.45, wherein R is a divalent hydrocarbon group, and
ii) the aqueous composition has a temperature of no more than 10° C.
13 . The aqueous composition of claim 12 wherein the esterified cellulose ether comprises groups of the formula —C(O)—CH 2 —CH 2 —COOH and additionally comprises aliphatic monovalent acyl groups.
14 . The aqueous composition of claim 12 wherein the total degree of ester substitution of the esterified cellulose ether is up to 1.0.
15 . The aqueous composition of claim 12 wherein the esterified cellulose ether is hydroxypropyl methylcellulose acetate succinate wherein the degree of neutralization of the groups —C(O)—CH 2 —CH 2 —COOH is not more than 0.1.