Crystalline form of a proteasome inhibitor
View Patent ↗The present disclosure relates to a novel crystalline form of a proteasome inhibitor, and to the processes for the preparation thereof. The novel crystalline form according to the disclosure may be used in the preparation of pharmaceutical compositions for the treatment of cancer.
1. A crystalline form comprising N,N′,N″-[2,4,6-boroxintriyltris[[(1R)-3-methylbutylidene]imino(2-oxo-2,1-ethanediyl)]]tris(2,5-dichlorobenzamide) having the structure of Formula (1b):
2. The crystalline form according to claim 1 , wherein the crystalline form is crystalline Pattern B comprising an X-ray powder diffraction pattern having characteristic peaks expressed in degrees two-theta at approximately 5.79±0.20, 10.63±0.20, 16.06±0.20, and 23.58±0.20.
3. The crystalline form according to claim 1 , wherein the crystalline form is crystalline Pattern B comprising an X-ray powder diffraction pattern having characteristic peaks expressed in degrees two-theta at approximately 5.79±0.20, 10.63±0.20, 16.06±0.20, 17.12±0.20, 17.93±0.20, 19.69±0.20, 23.58±0.20, 24.17±0.20 and 24.93±0.20.
4. The crystalline form according to claim 1 , wherein the crystalline form is crystalline Pattern B comprising an X-ray powder diffraction pattern having a reference peak expressed in degrees two-theta at 5.79±0.20, and having peaks in degrees two-theta angles of 4.84, 10.27, 17.79 relative to the reference peak.
5. The crystalline form according to claim 1 , wherein the crystalline form is crystalline Pattern B comprising an X-ray powder diffraction pattern having a reference peak expressed in degrees two-theta at 5.79±0.20, and having peaks in degrees two-theta angles of 4.84, 10.27, 11.33, 12.14, 13.90, 17.79, 18.38, 19.14 relative to the reference peak.
6. The crystalline form according to claim 1 , wherein the crystalline form is crystalline Pattern B comprising an X-ray powder diffraction pattern having characteristic peaks expressed in degrees two-theta at approximately:
Angles (°2θ) ± 0.20
Intensity (%)
5.79
100
6.98
18
9.46
13
9.89
33
10.63
70
11.40
16
12.41
13
13.96
32
14.13
29
14.38
16
16.06
75
16.73
27
17.12
68
17.53
23
17.93
61
18.58
28
19.26
20
19.69
68
20.05
25
20.65
18
21.37
24
21.99
33
22.59
11
23.58
80
24.17
67
24.33
32
24.93
39
25.26
15
26.11
12
26.54
13
26.92
11
28.12
11
28.46
11
29.36
11
29.59
10.
7. The crystalline form according to claim 1 , having a DSC profile characterized by an endothermic transition at about 123.4° C.
8. The crystalline form according to claim 1 , having a DSC profile characterized by an endothermic transition at about 120° C. to about 125° C.
9. The crystalline form according to claim 8 , having a DSC profile characterized by an endothermic transition of about 123.0° C.
10. The crystalline form according to claim 1 , having a TGA profile losing about 1.9% weight up to 150° C. at a temperature rate of 10° C. per minute, and decomposition at about 272±5° C.
11. The crystalline form according to claim 1 , wherein the crystalline form is a monohydrate.
12. A method for the preparation of the crystalline form according to claim 1 , wherein the crystalline form is crystalline Pattern B, comprising:
(a) adding a non-crystalline solid comprising a compound of Formula (Ib) to a solvent or solvent mixture
(b) stirring the resulting mixture for a sufficient amount of time to form crystalline Pattern B; and optionally
(c) isolating crystalline Pattern B.
13. The method according to claim 12 , wherein the solvent or solvent mixture is acetone/water (1:3), DMF/water (1:2), iso-propyl acetate, or THF/water (1:10).
14. A method for the preparation of the crystalline form according to claim 1 , wherein the crystalline form is crystalline Pattern B, comprising:
(a) dissolving or suspending a non-crystalline solid comprising a compound of Formula (Ib) in a solvent
(b) adding a second agent to the suspension or solution at a predetermined temperature;
(c) stirring the above mixture for a sufficient amount of time to form crystalline Pattern B; and optionally
(d) isolating the resulting crystalline Pattern B.
15. The method according to claim 14 , wherein the solvent is ethyl acetate.
16. The method according to claim 14 , wherein the second agent is anethole, methyl benzoate, methyl cinnamate, triacetin, triethyl citrate, or caffeine.
17. The method of according claim 14 , wherein the temperature is between about 15° C. to about 35° C.
18. A process for producing the crystalline form according to claim 1 , wherein the crystalline form is crystalline Pattern B, comprising:
(a) adding crystalline Pattern B as seeding material to a solution of non-crystalline solid comprising the compound of Formula (Ib)
(b) stirring the solution at a predetermined temperature for a sufficient amount of time; and optionally
(c) collecting the resulting crystalline Pattern B.
19. The process according to claim 18 , wherein the seeding material is about 0.1% to about 5%, or about 5% to about 10%, or about 10% to about 20% by weight of the amount of non-crystalline solid of Formula (Ib).
20. The process of claim 18 , wherein the solution is ethyl acetate solution.
21. The process of claim 18 , wherein the temperature is between about 15° C. to about 40° C.
22. The process of claim 18 , wherein the amount of time is from 4 hours to 24 hours.
23. A pharmaceutical composition comprising the crystalline form of claim 1 ; and a pharmaceutically acceptable carrier.