Solid dispersions
An ospemifene solid dispersion for enhancing solubility and bioavailability, and methods of preparation thereof are disclosed. The solid dispersion comprises an active pharmaceutical ingredient, such as ospemifene, and a hydfophilie carrier, such as copovidone, hypromellose acetate succinate, polyvinylpyrrolidine, a polyvinylpyrrolidine/vinyl acetate co-polymer, hydroxyl propyl methylcellulose, hypromellose acetate succinate, a Eudragit® compound, hydroxypropylcellulose, a polyvinyl caprolactam-polyvinyl acetate polyethylene glycol graft co-polymer, hydroxypropyl methylcellulose phthalate, and mixtures thereof, and optionally a surfactant The ospemifene solid, dispersions can be used in methods of treating a symptom related, to menopause, such as vaginal dryness or sexual dysfunction, or in methods of treating osteoporosis.
1. A solid dispersion composition in a solid state composition comprising a solid dispersion of ospemifene, wherein the solid dispersion comprises:
ospemifene; and
a hydrophilic carrier selected from the group consisting of copovidone, polyvinylpyrrolidone, a polyvinylpyrrolidone/vinyl acetate co-polymer, hydroxyl propyl methylcellulose, hypromellose acetate succinate, a methacrylic acid copolymer, hydroxypropylcellulose, a polyvinyl caprolactam-polyvinyl acetate polyethylene glycol graft co-polymer, hydroxypropyl methylcellulose phthalate, and mixtures thereof,
wherein the solid dispersion is in a solid state.
2. The composition of claim 1 , wherein the ratio of ospemifene to the hydrophilic carrier is in a range of about 1:1 to about 1:20 (w/w).
3. The composition of claim 1 , wherein the ratio of ospemifene to the hydrophilic carrier is about 1:4 (w/w).
4. The composition of claim 1 , wherein the solid dispersion further comprises a surfactant.
5. A pharmaceutical composition comprising the composition of claim 1 and a pharmaceutically acceptable excipient.
6. The pharmaceutical composition of claim 5 , wherein the pharmaceutical composition is provided in a dosage form.
7. The pharmaceutical composition of claim 5 , wherein the pharmaceutically acceptable excipient comprises at least one of a glidant, a dispersant, an enteric coating, a lubricant, a binder, or a buffering agent.
8. The pharmaceutical composition of claim 5 , wherein the hydrophilic carrier and surfactant are combined in a ratio ranging from 1:1 to 1:6.
9. The pharmaceutical composition of claim 5 , wherein the pharmaceutically acceptable excipient is selected from at least one of colloidal silicon dioxide, lactose monohydrate, magnesium stearate, mannitol, microcrystalline cellulose, polyethylene glycol, pregelatinized starch, sodium starch glycolate, titanium dioxide, triacetin, and triose, and mixtures thereof.
10. The pharmaceutical composition of claim 5 , wherein after a single administration in a human subject of the pharmaceutical composition there is greater bioavailability or no difference in the bioavailability of ospemifene when the composition is administered to the subject in a fasted versus a fed state.
11. The composition of claim 1 , wherein the hydrophilic carrier is a polyvinylpyrrolidone/vinyl acetate co-polymer.
12. The composition of claim 1 , wherein the ospemifene is amorphous.
13. The composition of claim 1 , wherein the hydrophilic carrier is selected from the group consisting of a polyvinylpyrrolidone/vinyl acetate co-polymer, hypromellose acetate succinate, hydroxypropylcellulose, a polyvinyl caprolactam-polyvinyl acetate polyethylene glycol graft co-polymer, and hydroxypropyl methylcellulose phthalate.