IP Library › Granted Patent US 11,203,753
Granted Patent B2
US 11,203,753 · App. 15/557,646 · Granted Dec 21, 2021

Hepcidin antagonists for use in the treatment of inflammation

Inventors: Carole Peyssonnaux (Pairs, FR); Jacques Mathieu (Paris, FR); Sara Zumerle (Paris, FR)
Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale); Centre National de la Recherche Scientifique (CNRS); Université Paris Descartes; Université Paris Diderot—Paris 7
C12N15/113A61K31/713A61K31/7105A61K31/77C07K16/26C12N15/115A61K9/0031C12N2310/11C12N2310/12C12N2310/14C12N2310/16C12N2310/531
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Quick Facts
Patent No.
US 11,203,753
App. No.
15/557,646
Granted
Dec 21, 2021
Kind
B2
Abstract

The present invention relates to a hepcidin antagonist for use in the treatment of inflammatory diseases.

Claims (2)

1. A method for treating psoriasis, said method comprising a step of administering a hepcidin antagonist to a patient in need thereof, wherein said hepcidin antagonist is administered topically to the skin, and wherein said hepcidin antagonist is selected from the group consisting of anti-hepcidin antibodies, anti-hepcidin aptamers, lexaptepid pegol, the PRS-080 compound and an antisense oligonucleotide targeting the hepcidin gene, wherein the anti-hepcidin aptamer is a peptide aptamer having an anti-hepcidin antibody variable region and wherein the antisense oligonucleotide comprises a sequence that is complementary to a region of hepcidin mRNA.

2. The method according to claim 1 , wherein the hepcidin antagonist is administered in an amount sufficient to inhibit and/or reduce neutrophil migration.

Assignments (3)
MERGER AND CHANGE OF NAME Recorded May 3, 2022
From: UNIVERSITE PARIS DESCARTES; UNIVERSITÉ PARIS DIDEROT - PARIS 7; UNIVERSITE DE PARIS
To: UNIVERSITE DE PARIS
Reel/Frame 059795/0703 →
CHANGE OF NAME Recorded May 3, 2022
From: UNIVERSITE DE PARIS
To: UNIVERSITÉ PARIS CITÉ
Reel/Frame 059925/0756 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 19, 2017
From: PEYSSONNAUX, CAROLE; MATHIEU, JACQUES; ZUMERLE, SARA
To: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS; UNIVERSITE PARIS DESCARTES; UNIVERSITE PARIS DIDEROT - PARIS 7
Reel/Frame 043904/0930 →
Priority Claims (1)
EP 15159033 · Mar 13, 2015 · regional
Continuity (1)
Related Publication 20180057812A1 · Mar 1, 2018