Isolated peptides and fragments thereof from fibrinogen for use as drugs, particularly in skin inflammatory diseases
A present invention relates to isolated peptides obtained from human fibrinogen for their use as drug, particularly for the prevention and/or the treatment of inflammatory skin diseases, more particularly acne. The present invention also relates to fragments of these polypeptides, nucleic acid molecules encoding them, expression vectors, host cells, a pharmaceutical composition and a combination product containing them, and their use for treating and/or preventing inflammatory skin diseases, particularly acne.
1. A method for treating and/or preventing a skin inflammatory disease comprising administering to a subject in need thereof an isolated polypeptide comprising an amino acid sequence with at least 80% identity with SEQ ID NO:1 after optimal global alignment or a fragment thereof comprising an amino acid sequence with at least 80% identity with any one of SEQ ID NOs:2, 5, 7, 8, 9, 10, 11, 12, 13, and 47 after optimal global alignment.
2. The method according to claim 1 , wherein said polypeptide is selected from SEQ ID NOs:2, 5, 7, 8, 9, 10, 11, 12, 13, and 47 or a polypeptide with at least 80% identity with one of SEQ ID NOs: 2, 5, 7, 8, 9, 10, 11, 12, 13, and 47 after optimal global alignment.
3. The method according to claim 1 , wherein the skin inflammatory diseases is acne.
4. The method according to claim 1 , wherein said isolated polypeptide or fragment thereof inhibits the interaction with fibrinogen of at least one microbial protein involved in bacterial adhesion to a host cell.
5. The method according to claim 1 , wherein the skin inflammatory disease is psoriasis.
6. The method according to claim 1 , wherein said isolated polypeptide or fragment thereof inhibits the interaction with fibrinogen of at least one microbial protein involved in bacterial adhesion to a host cell, wherein the bacteria is P. acnes , and wherein the fibrinogen is human fibrinogen.