Removable film forming gel compositions and methods for their application
Film forming gel compositions, useful in creating conformable and flexible gel bandages, can be formulate from a film-forming polymer, a tackifier, and a volatile solvent. The film forming gels can also include antiseptics, cationic polymer coagulants, fillers, and other additives. The gel compositions form relatively thick films when dried on tissue, and can exhibit enhanced breathability to promote wound healing.
1. A film forming gel composition comprising:
10-30 wt. % of a silicone containing, film forming polymer based on the total weight of the gel composition, wherein the silicone containing, film forming polymer comprises a polydiorganosiloxane polyoxamide;
3-20 wt. % of a tackifier based on the total weight of the gel composition, the tackifier comprising a silicate tackifying resin;
0.5-20 wt % of a plurality of coagulant particles based on the total weight of the gel composition, the plurality of coagulant particles comprises a crosslinked guanidinyl-containing polymer having primary or secondary amino groups;
and 60-80 wt/ % of a volatile solvent based on the total weight of the film forming gel composition, and
wherein a film cast from the film forming gel composition is self-supporting on a biological substrate and can be peeled off the substrate without substantially compromising the integrity of the film such that at least a portion of the film is removable in a single continuous layer.
2. The composition of claim 1 , further comprising 0.1-15 wt. % silicone surfactant, based on the total weight of the gel composition.
3. The composition of claim 1 , wherein the guanidinyl-containing polymer is an aminopolymer functionalized with one or more guanidinyl groups.
4. The composition of claim 3 , wherein the guanidinyl-containing polymer is guanidinylated polyethyleneimine.
5. The composition of claim 1 , wherein the coagulant comprises at least 1.5 wt. % and no greater than 10 wt. % of the gel composition based on the total weight of the gel composition.
6. The composition of claim 1 , wherein the tackifier comprises an MQ silicate tackifying resin.
7. The composition of claim 1 and further comprising an antiseptic agent, wherein the antiseptic comprises at least one of octenidine, chlorhexidine salt, alexidine salt, polyhexamethylene biguanide salt, benzalkonium salt, cetyl pyridinium salt, cetrimonium salt, or benzethonium salt, and combinations thereof.
8. The composition of claim 7 , wherein the antiseptic is present at a concentration of at least 0.1 wt. % and no greater than 1.0 wt. %, based on the total weight of the gel composition.
9. The composition of any claim 8 , wherein the active kill of a dried film cast from the gel composition is at least 3 log reduction of a target microorganism according to the Antimicrobial Efficacy Test Method, and wherein the target microorganism is one or more of Staphylococcus aureus, Escherichia coli , and Pseudomonas aeruginosa.
10. The composition of claim 7 , wherein the gel composition includes an effective amount of an antiseptic surfactant, the antiseptic surfactant comprising a straight chain 1,2-alkanediols having a chain length in the range of 5 to 10 carbon atoms.
11. The composition of claim 1 , wherein the volatile solvent is selected from the group consisting of volatile linear and cyclic siloxanes, volatile polydimethylsiloxanes, isooctane, octane, and combinations thereof.
12. The composition of claim 1 , wherein a film cast from the gel composition exhibits an elongation of at least 100%, and an ultimate tensile strength of at least 0.3 MPa after drying on a biological substrate.
13. The composition of claim 12 , wherein the film exhibits an upright MVTR of at least 300 g/m 2 /24 hours, a Skin Adhesion of at least 50 g/inch and no greater than 900 g/inch.