THERAPEUTIC COMPOSITION CONTAINING ANTITHROMBIN GAMMA
The present invention pertains to a therapeutic composition comprising antithrombin gamma for diffuse intravascular coagulation or disseminated intravascular coagulation involving a decrease of antithrombin, or for thrombophilia due to congenital antithrombin deficiency.
1 . A therapeutic composition for diffuse intravascular coagulation or disseminated intravascular coagulation involving a decrease of antithrombin comprising:
isolated antithrombin gamma in a total daily dose of 36 international units/kg,
wherein the therapeutic composition is administered by intravenous injection or intravenous drip infusion.
2 . A therapeutic composition for obstetrical or surgical diffuse intravascular coagulation or disseminated intravascular coagulation comprising:
isolated antithrombin gamma in a total daily dose of 48 to 72 international units/kg,
wherein the therapeutic composition is administered as an emergency by intravenous injection or intravenous drip infusion.
3 . The therapeutic composition according to claim 1 , wherein the therapeutic composition is administered concurrently with continuous intravenous drip infusion of heparin.
4 . A therapeutic composition for thrombophilia due to congenital antithrombin deficiency comprising:
isolated antithrombin gamma in a total daily dose of 24 to 72 international units/kg,
wherein the therapeutic composition is administered by intravenous injection or intravenous drip infusion.
5 . The therapeutic composition according to claim 4 , wherein the dose is determined while monitoring an antithrombin activity level.
6 . The therapeutic composition according to claim 1 , wherein the therapeutic composition is administered once daily.
7 . The therapeutic composition according to claim 1 , wherein the therapeutic composition is administered daily in at least two divided doses.
8 . The therapeutic composition according to claim 2 , wherein the therapeutic composition is administered concurrently with continuous intravenous drip infusion of heparin.
9 . The therapeutic composition according to claim 2 , wherein the therapeutic composition is administered once daily.
10 . The therapeutic composition according to claim 4 , wherein the therapeutic composition is administered once daily.
11 . The therapeutic composition according to claim 2 , wherein the therapeutic composition is administered daily in at least two divided doses.
12 . The therapeutic composition according to claim 4 , wherein the therapeutic composition is administered daily in at least two divided doses.