IP Library › Granted Patent US 10,851,176
Granted Patent B2
US 10,851,176 · App. 15/565,933 · Granted Dec 1, 2020

Methods of administering neutralizing anti-protease nexin-1 antibodies to treat hemophilia A

Inventors: Marie-Christine Bouton (Paris, FR); Petrus Lenting (Le Kremlin-Bicêtre, FR); Cécile Denis (Le Kremlin-Bicêtre, FR); Olivier Christophe (Le Kremlin-Bicêtre, FR)
Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE); UNIVERSITE PARIS DIDEROT—PARIS 7; UNIVERSITE PARIS XIII PARIS-NORD
C07K16/38C07K16/40A61K2039/505C07K2317/76
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Quick Facts
Patent No.
US 10,851,176
App. No.
15/565,933
Granted
Dec 1, 2020
Kind
B2
Abstract

The present invention relates to a method and compositions for the treatment of haemorrhagic diseases.

Claims (4)

1. A method for treating mild or moderate haemophilia A in a subject in need thereof, comprising the step of administering to said subject a protease nexin-1 activity inhibitor, wherein the protease nexin-1 activity inhibitor is an anti-protease nexin-1 neutralizing antibody.

2. The method of claim 1 , wherein the protease nexin-1 activity inhibitor is administered in combination with one or more coagulation factors.

3. The method of claim 2 , wherein the one or more coagulation factors is selected from the group consisting of factor VIII, factor IX, factor Vila, plasma-derived activated prothrombin complex and fibrinogen.

4. The method of claim 1 , wherein the protease nexin 1 activity inhibitor is fused to a platelet targeting agent.

Assignments (5)
CORRECTIVE ASSIGNMENT TO CORRECT THE PROPERTY NUMBER 16930208 PREVIOUSLY RECORDED AT REEL: 060541 FRAME: 0336. ASSIGNOR(S) HEREBY CONFIRMS THE MERGER AND CHANGE OF NAME. Recorded Jan 11, 2023
From: UNIVERSITE PARIS DESCARTES; UNIVERSITE PARIS DIDEROT - PARIS 7
To: UNIVERSITE DE PARIS
Reel/Frame 062387/0346 →
CORRECTIVE ASSIGNMENT TO CORRECT THE PROPERTY NUMBER 16930208 PREVIOUSLY RECORDED AT REEL: 060390 FRAME: 0122. ASSIGNOR(S) HEREBY CONFIRMS THE CHANGE OF NAME. Recorded Jan 11, 2023
From: UNIVERSITE DE PARIS
To: UNIVERSITÉ PARIS CITÉ
Reel/Frame 062387/0489 →
CHANGE OF NAME Recorded Jun 20, 2022
From: UNIVERSITE DE PARIS
To: UNIVERSITÉ PARIS CITÉ
Reel/Frame 060390/0122 →
MERGER AND CHANGE OF NAME Recorded Jun 20, 2022
From: UNIVERSITE PARIS DESCARTES; UNIVERSITE PARIS DIDEROT - PARIS 7; UNIVERSITE DE PARIS
To: UNIVERSITE DE PARIS
Reel/Frame 060541/0336 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 12, 2017
From: BOUTON, MARIE-CHRISTINE; LENTING, PETRUS; DENIS, CECILE; CHRISTOPHE, OLIVIER
To: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE); UNIVERSITE PARIS DIDEROT - PARIS 7; UNIVERSITE PARIS XIII PARIS-NORD
Reel/Frame 043845/0889 →