IP Library › Granted Patent US 10,703,756
Granted Patent B2
US 10,703,756 · App. 15/569,874 · Granted Jul 7, 2020

Pyrrolo[2,3-D]pyrimidinyl, pyrrolo[2,3-B]pyrazinyl, pyrrolo[2,3-B]pyridinyl acrylamides and epoxides thereof

Inventors: Atli Thorarensen (Stow, MA); Matthew Frank Brown (Stonington, CT); Agustin Casimiro-Garcia (Concord, MA); Ye Che (Groton, CT); Mark Edward Flanagan (Gales Ferry, CT); Adam Matthew Gilbert (Guilford, CT); Matthew Merrill Hayward (Old Lyme, CT); Jean-Baptiste Telliez (Lexington, MA); Rayomand Jal Unwalla (Bedford, MA); John I. Trujillo (Ledyard, CT); Sidney Xi Liang (Bethany, CT)
Assignee: Pfizer Inc.
C07D487/04
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Quick Facts
Patent No.
US 10,703,756
App. No.
15/569,874
Granted
Jul 7, 2020
Kind
B2
Abstract

The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, and pyrrolo[2,3-b]pyridinyl acrylamides, epoxides, and analogues thereof. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK.

Claims (5)

1. The compound 2-{[(2S)-1-acryloylpyrrolidin-2-yl]methoxy}-N-[(2S)-1-methoxypropan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide; or, a pharmaceutically acceptable salt thereof.

2. The compound 2-[(1-acryloylpiperidin-4-yl)amino]-N-(3-fluorobenzyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide; or, a pharmaceutically acceptable salt thereof.

3. The compound 2-[(1-acryloylpiperidin-4-yl)amino]-N-(2-cyclopropylethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide; or, a pharmaceutically acceptable salt thereof.

4. The compound 2-[(1-acryloylpiperidin-4-yl)amino]-N-benzyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide; or, a pharmaceutically acceptable salt thereof.

5. The compound 2-[(1-acryloylpiperidin-4-yl)oxy]-N-[(2R)-1-methoxypropan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide; or a pharmaceutically acceptable salt thereof.

Assignments (1)
ASSIGNEE ADDRESS CORRECTION Recorded Mar 20, 2023
From: PFIZER INC.
To: PFIZER INC.
Reel/Frame 063119/0087 →