IP Library Granted Patent US 10,385,043
Granted Patent B2
US 10,385,043 · App. 15/575,332 · Granted Aug 20, 2019

Crystalline form of the compound (S)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol

Inventor: Cyrille Lescop (Allschwil, CH)
Assignee: IDORSIA PHARMACEUTICALS LTD
C07D413/04A61K31/047A61K31/4245A61K31/44A61P37/00G01N23/20075
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Quick Facts
Patent No.
US 10,385,043
App. No.
15/575,332
Granted
Aug 20, 2019
Kind
B2
Abstract

The present invention relates to a crystalline form of the compound (S)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol.

Claims (9)

1. A crystalline form of the compound (S)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol, characterised by the presence of peaks in the X-ray powder diffraction diagram at the following angles of refraction 2θ: 5.4°, 8.5°, and 10.8°.

2. The crystalline form according to claim 1 , characterised by the presence of peaks in the X-ray powder diffraction diagram at the following angles of refraction 2θ: 4.2°, 5.4°, 8.0°, 8.5°, and 10.8°.

3. The crystalline form according to claim 1 , characterised by the presence of peaks in the X-ray powder diffraction diagram at the following angles of refraction 2θ: 4.2°, 5.4°, 8.0°, 8.5°, 10.8°, 12.7°, 14.4°, 17.7°, 20.4°, and 21.3°.

4. The crystalline form according to claim 2 , which essentially shows the X-ray powder diffraction pattern as depicted in FIG. 1 .

5. The crystalline form according to claim 2 , which has a melting point of about 79° C. as determined by differential scanning calorimetry.

6. A pharmaceutical composition comprising the crystalline form according to claim 1 and a pharmaceutically acceptable carrier.

7. A method of treating a disease or disorder comprising administering a pharmaceutically active amount of the crystalline form according to claim 1 to a subject in need thereof, wherein the disease or disorder is selected from the group consisting of rejection of transplanted organs selected from kidney, liver, heart, lung, pancreas, cornea, and skin; graft-versus-host disease; autoimmune syndromes selected from Sjögren's syndrome, spondylarthropathy/ankylosing spondylitis, juvenile arthritis, lupus nephritis, systemic sclerosis, diffuse cutaneous systemic sclerosis, vascilitis, giant cell arteritis, Behcet disease, non-infectious uveitis, Goodpasture syndrome, primary biliary cirrhosis, autoimmune hepatitis, vitiligo, alopecia areata, Rasmussen's encephalitis, rheumatoid arthritis, multiple sclerosis, Crohn's disease, ulcerative colitis, and psoriasis; atopic dermatitis; and type I diabetes.

8. A method of treating a disease or disorder comprising administering a pharmaceutically active amount of the crystalline form according to claim 1 to a subject in need thereof, wherein the disease is systemic lupus erythematosus.

9. A method of treating a disease or disorder comprising administering a pharmaceutically active amount of the crystalline form according to claim 3 to a subject in need thereof, wherein the disease is systemic lupus erythematosus.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 6, 2024
From: IDORSIA PHARMACEUTICALS LTD.
To: VIATRIS ASIA PACIFIC PTE. LTD.
Reel/Frame 067647/0303 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 23, 2018
From: ACTELION PHARMACEUTICALS LTD
To: IDORSIA PHARMACEUTICALS LTD
Reel/Frame 044705/0234 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 22, 2018
From: LESCOP, CYRILLE
To: ACTELION PHARMACEUTICALS LTD
Reel/Frame 044691/0810 →
Priority Claims (1)
WO PCT/EP2015/061153 · May 20, 2015 · international
Continuity (1)
Related Publication 20180141936A1 · May 24, 2018