IP Library › Granted Patent US 10,874,748
Granted Patent B2
US 10,874,748 · App. 15/577,470 · Granted Dec 29, 2020

Intervention for tendinopathy

Inventors: Hui B. Sun (Chappaqua, NY); Evan L. Flatow (New York, NY); Tony Wanich (Englewood Cliffs, NJ); Konrad Gruson (New York, NY); Nelly Andarawis-Puri (New York, NY)
Assignees: Albert Einstein College of Medicine; Icahn School of Medicine at Mount Sinai; Montefiore Medical Center
A61K48/00A61K45/06A61K48/0091A61L27/386A61P21/00C12N5/066C12N2501/60C12N2510/02
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Quick Facts
Patent No.
US 10,874,748
App. No.
15/577,470
Granted
Dec 29, 2020
Kind
B2
Abstract

Methods for treating tendinopathy and tendonitis and for preventing tendinopathy are disclosed.

Claims (6)

1. A method of treating a tendinopathy in a subject comprising administering to the subject tendon stem/progenitor cells (TSPCs) transduced or transfected with a vector comprising CREB-binding protein/p300-interacting protein 2 (CITED2) cDNA, wherein the TSPCs are administered to the site of the tendinopathy in an amount effective to treat the tendinopathy in the subject, and wherein the subject does not have a ruptured tendon.

2. The method of claim 1 , wherein the TSPCs have been obtained from a human prior to their transduction or transfection.

3. The method of claim 1 , wherein the TSPCs have been obtained from a human biceps brachii tendon.

4. The method of claim 1 , wherein the tendinopathy is of an Achilles tendon, a knee tendon or an arm tendon.

5. The method of claim 1 , wherein the tendinopathy comprises a tendinosis or a tendonitis.

6. The method of claim 1 , wherein the subject is a human.

Assignments (3)
MERGER AND CHANGE OF NAME Recorded Feb 26, 2019
From: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.; ALBERT EINSTEIN COLLEGE OF MEDICINE
To: ALBERT EINSTEIN COLLEGE OF MEDICINE
Reel/Frame 048438/0275 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 18, 2018
From: WANICH, TONY
To: MONTEFIORE MEDICAL CENTER
Reel/Frame 047219/0742 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 17, 2018
From: GRUSON, KONRAD
To: MONTEFIORE MEDICAL CENTER
Reel/Frame 045563/0449 →