NOVEL PEPTIDES AND PEPTIDOMIMETICS
Compounds and compositions comprising a gap junction channel or hemichannel blocker or inhibitor, and methods of use thereof, are provided for the treatment or prevention of vascular and other diseases, disorders, and conditions.
1 . A pharmaceutical composition comprising a compound selected from the group consisting of SEQ ID NOS:1-52 and a pharmaceutically acceptable carrier.
2 . A pharmaceutical composition comprising a compound according to Formula I, and a pharmaceutically acceptable carrier.
3 . A pharmaceutical composition comprising a compound according to Formula II, and a pharmaceutically acceptable carrier.
4 . A pharmaceutical composition comprising a compound according to Formula III, and a pharmaceutically acceptable carrier.
5 . A pharmaceutical composition comprising a compound according to Formula IV, and a pharmaceutically acceptable carrier.
6 . An isolated compound selected from the group consisting of SEQ ID NOS:1-52.
7 . An isolated compound selected according to Formula I.
8 . An isolated compound selected according to Formula II.
9 . An isolated compound selected according to Formula III.
10 . An isolated compound selected according to Formula IV.
11 . A pharmaceutical composition of claim 1 , wherein the compound is selected from SEQ ID NOS: 1-10, 21, 25, 27-30, 46, 49, 50, and 51; and the pharmaceutically acceptable carrier comprises a sterile excipient.