IP Library Granted Patent US 10,434,319
Granted Patent B2
US 10,434,319 · App. 15/585,091 · Granted Oct 8, 2019

System and method of identifying sources associated with biological rhythm disorders

Inventors: Sanjiv M. Narayan (Palo Alto, CA); Carey Robert Briggs (La Jolla, CA); Ruchir Sehra (Scottsdale, AZ)
Assignees: The Regents of the University of California; The United States of America as Represented by the Department of Veterans Affairs; Topera, Inc.
A61N1/3712A61B5/0006A61B5/02405A61B5/0422A61N1/365A61N1/3622A61N1/378A61B2018/00577A61M2230/06
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Quick Facts
Patent No.
US 10,434,319
App. No.
15/585,091
Granted
Oct 8, 2019
Kind
B2
Abstract

An example system and method associated with identifying and treating a source of a heart rhythm disorder are disclosed. In accordance therewith, a spatial element associated with a region of the heart is selected. Progressive rotational activations or progressive focal activations are determined in relation to the selected spatial element over a period of time. The selecting and determining are repeated over multiple periods of time. A source parameter of rotation activations or focal activations is determined, wherein the source parameter indicates consistency of successive rotational activations or focal activations in relation to a portion of the region of the heart. The determining of a source parameter is repeated for multiple regions of the heart. Thereafter, representation of the source parameter is displayed for each of the multiple regions of the heart to identify a shape representing the source of the heart rhythm disorder.

Claims (55)

1. A method associated with identifying a source of a heart rhythm disorder, the method comprising a computing device:

selecting a spatial element associated with a region of the heart;

determining progressive rotational activations or progressive focal activations in relation to the selected spatial element over a period of time;

repeating the selecting and determining over multiple periods of time;

determining an index of rotational activations or focal activations, wherein the index indicates consistency of successive rotational activations or focal activations in relation to a portion of the region of the heart;

repeating the determining of an index for multiple regions of the heart; and

displaying a representation of the index for each of the multiple regions of the heart to identify a shape representing the source of the heart rhythm disorder.

2. The method of claim 1 , wherein the index is associated with a frequency of successive rotational activations in the region of the heart.

3. The method of claim 1 , wherein the index is associated with a frequency of progressive angular displacement in the region of the heart.

4. The method of claim 1 , wherein the index is a regularity with which the rotational activations or focal activations are present.

5. The method of claim 4 , wherein the regularity is one of periodicity, repetitiveness, and/or frequency of occurrence of rotational or focal activations.

6. The method of claim 1 , wherein displaying the representation of the index comprises displaying a representation of an arithmetic mean of the index of the region over time.

7. The method of claim 1 , wherein displaying the representation of the index comprises displaying a representation of a geometric mean of the index of the region over time.

8. The method of claim 1 , wherein displaying the representation of the index comprises displaying a representation of a weighted average of the index of the region over time.

9. The method of claim 1 , further comprising displaying the representation of the index on at least one of an isolated display, a three-dimensional abstract representation, a three-dimensional representation of the cardiac tissue or a polar representation.

10. A system associated with identifying a source of a heart rhythm disorder, the system comprising:

a processor; and

a memory storing instructions that, when executed by the processor, cause the processor to perform operations comprising:

selecting a spatial element associated with a region of the heart;

determining progressive rotational activations or progressive focal activations in relation to the selected spatial element over a period of time;

repeating the selecting and determining over multiple periods of time;

determining an index of rotational activations or focal activations, wherein the index indicates consistency of successive rotational activations or focal activations in relation to a portion of the region of the heart;

repeating the determining of an index for multiple regions of the heart; and

displaying a representation of the index for each of the multiple regions of the heart to identify a shape representing the source of the heart rhythm disorder.

11. The system of claim 10 , wherein the index is associated with a frequency of successive rotational activations in the region of the heart.

12. The system of claim 10 , wherein the index is associated with a frequency of progressive angular displacement in the region of the heart.

13. The system of claim 10 , wherein the index is a regularity with which the rotational activations or focal activations are present.

14. The system of claim 13 , wherein the regularity is one of periodicity, repetitiveness, and/or frequency of occurrence of rotational or focal activations.

15. The system of claim 10 , wherein displaying the representation of the index comprises displaying a representation of an arithmetic mean of the index of the region over time.

16. The system of claim 10 , wherein displaying the representation of the index comprises displaying a representation of a geometric mean of the index of the region over time.

17. The system of claim 10 , wherein displaying the representation of the index comprises displaying a representation of a weighted average of the index of the region over time.

18. The system of claim 10 , wherein the representation of the index is displayed on at least one of an isolated display, a three-dimensional abstract representation, a three-dimensional representation of the cardiac tissue or a polar representation.

19. A non-transitory storage medium storing instructions that, when executed by a processor, cause the processor to perform operations associated with identifying a source of a heart rhythm disorder, the operations comprising:

selecting a spatial element associated with a region of the heart;

determining progressive rotational activations or progressive focal activations in relation to the selected spatial element over a period of time;

repeating the selecting and determining over multiple periods of time;

determining an index of rotational activations or focal activations, wherein the index indicates consistency of successive rotational activations or focal activations in relation to a portion of the region of the heart;

repeating the determining of an index for multiple regions of the heart; and

displaying a representation of the index for each of the multiple regions of the heart to identify a shape representing the source of the heart rhythm disorder.

20. The storage medium of claim 19 , wherein the index is associated with a frequency of successive rotational activations in the region of the heart.

21. The storage medium of claim 19 , wherein the index is associated with a frequency of progressive angular displacement in the region of the heart.

22. The storage medium of claim 19 , wherein the index is a regularity with which the rotational activations or focal activations are present.

23. The storage medium of claim 22 , wherein the regularity is one of periodicity, repetitiveness, and/or frequency of occurrence of rotational or focal activations.

24. The storage medium of claim 19 , wherein displaying the representation of the index comprises displaying a representation of an arithmetic mean of the index of the region over time.

25. The storage medium of claim 19 , wherein displaying the representation of the index comprises displaying a representation of a geometric mean of the index of the region over time.

26. The storage medium of claim 19 , wherein displaying the representation of the index comprises displaying a representation of a weighted average of the index of the region over time.

27. The storage medium of claim 19 , wherein the representation of the index is displayed on at least one of an isolated display, a three-dimensional abstract representation, a three-dimensional representation of the cardiac tissue or a polar representation.

28. A method of identifying and treating a source of a heart rhythm disorder, the method comprising a computing device:

selecting a spatial element associated with a region of the heart;

determining progressive rotational activations or progressive focal activations in relation to the selected spatial element over a period of time;

repeating the selecting and determining over multiple periods of time;

determining an index of rotational activations or focal activations, wherein the index indicates consistency of successive rotational activations or focal activations in relation to a portion of the region of the heart;

repeating the determining of an index for multiple regions of the heart;

displaying a representation of the index for each of the multiple regions of the heart to identify a shape representing the source of the heart rhythm disorder; and

selectively modifying a region of the heart associated with the shape in order to terminate or alter the heart rhythm disorder.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 24, 2017
From: NARAYAN, SANJIV M.
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 042498/0794 →
Continuity (5)
Continuation In Part 14473990 · Aug 29, 2014
Continuation In Part 13844562 · Mar 15, 2013
Provisional Application 62330734 · May 2, 2016
Provisional Application 61973626 · Apr 1, 2014
Related Publication 20170232263A1 · Aug 17, 2017