Devices and methods for gastrointestinal stimulation
An intragastric weight-loss device is disclosed. The device includes a proximal occlusion member comprising a spiral structure, a bridging member, and a distal occlusion member. The spiral structure can be configured to spiral into a bulbous shape when the proximal occlusion member is delivered into the stomach. The bridging member can extend from the proximal occlusion member. The distal occlusion member can be coupled to a distal end of the bridging member. The proximal occlusion member can be configured to intermittently obstruct a pyloric valve of a patient such that passage of food through the pyloric valve is slowed.
1. An intragastric weight-loss device, comprising:
a first occlusion member comprising a spiral structure, wherein the spiral structure is configured to form into a bulbous shape when the first occlusion member is delivered into the stomach;
a bridging member extending from the first occlusion member; and
a second occlusion member coupled to a distal end of the bridging member, wherein the first occlusion member is configured to intermittently block the pyloric valve of a patient after deployment of at least the first occlusion member of the intragastric weight-loss device such that passage of food through the pyloric valve is slowed.
2. The device of claim 1 , wherein the bulbous shape of the spiral structure is a substantially spherical shape.
3. The device of claim 1 , wherein the first occlusion member comprises a compressed delivery configuration and an expanded deployed configuration.
4. The device of claim 3 , wherein an outer dimension of the first occlusion member in the expanded deployed configuration is between about 50 mm and about 60 mm.
5. The device of claim 3 , wherein the first occlusion member is expandable from the compressed delivery configuration into the expanded deployed configuration when within the stomach.
6. The device of claim 1 , wherein a cross-sectional width of the bridging member is about 5 mm.
7. The device of claim 1 , wherein the second occlusion member is sized to pass through the pyloric valve through natural peristalsis.
8. The device of claim 1 , wherein the second occlusion member is substantially spherical in shape.
9. The device of claim 8 , wherein a diameter of the second occlusion member is smaller than an outer dimension of the first occlusion member in an expanded deployed configuration but larger than a cross-sectional width of the bridging member.
10. The device of claim 1 , further comprising a therapeutic substance configured to be released from the device.
11. The device of claim 10 , wherein the therapeutic substance is a drug.
12. The device of claim 1 , wherein a length of the bridging member is sized to span the length of the pyloric valve.
13. The device of claim 1 , wherein the first occlusion member further comprises a locking member configured to control delivery or removal of the device.
14. The device of claim 1 , wherein the first occlusion member comprises a shape-memory material.